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  1. Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential. Despite this large repertoire of potential ...

    Authors: Dominik Awad, Michael Prattes, Lisa Kofler, Ingrid Rössler, Mathias Loibl, Melanie Pertl, Gertrude Zisser, Heimo Wolinski, Brigitte Pertschy and Helmut Bergler

    Citation: BMC Biology 2019 17:46

    Content type: Research article

    Published on:

  2. Environmental resistomes include transferable microbial genes. One important resistome component is resistance to arsenic, a ubiquitous and toxic metalloid that can have negative and chronic consequences for h...

    Authors: Taylor K. Dunivin, Susanna Y. Yeh and Ashley Shade

    Citation: BMC Biology 2019 17:45

    Content type: Research article

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  3. Understanding the brain requires understanding behavior. New machine vision and learning techniques are poised to revolutionize our ability to analyze behaviors exhibited by animals in the laboratory. Here we ...

    Authors: Sandeep Robert Datta

    Citation: BMC Biology 2019 17:44

    Content type: Question and Answer

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  5. At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundl...

    Authors: Lora Winters, Ivana Ban, Marcel Prelogović, Iana Kalinina, Nenad Pavin and Iva M. Tolić

    Citation: BMC Biology 2019 17:42

    Content type: Research article

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  6. Intrabodies enable targeting of proteins in live cells, but generating specific intrabodies against the thousands of proteins in a proteome poses a challenge. We leverage the widespread availability of fluores...

    Authors: David L. Prole and Colin W. Taylor

    Citation: BMC Biology 2019 17:41

    Content type: Methodology article

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  7. The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation i...

    Authors: Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane and Christopher J. Brown

    Citation: BMC Biology 2019 17:40

    Content type: Research article

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  8. RNA regulation by RNA-binding proteins (RBPs) involve extremely complicated mechanisms. MOV10 and MOV10L1 are two homologous RNA helicases implicated in distinct intracellular pathways. MOV10L1 participates sp...

    Authors: Kaiqiang Fu, Suwen Tian, Huanhuan Tan, Caifeng Wang, Hanben Wang, Min Wang, Yuanyuan Wang, Zhen Chen, Yanfeng Wang, Qiuling Yue, Qiushi Xu, Shuya Zhang, Haixin Li, Jie Xie, Mingyan Lin, Mengcheng Luo…

    Citation: BMC Biology 2019 17:39

    Content type: Research article

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  9. Many methods have been developed to quantify cell shape in 2D in tissues. For instance, the analysis of epithelial cells in Drosophila embryogenesis or jigsaw puzzle-shaped pavement cells in plant epidermis ha...

    Authors: Özer Erguvan, Marion Louveaux, Olivier Hamant and Stéphane Verger

    Citation: BMC Biology 2019 17:38

    Content type: Methodology article

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  12. The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making...

    Authors: Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun and Brett Nixon

    Citation: BMC Biology 2019 17:35

    Content type: Research article

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  13. Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation ...

    Authors: Liliane Abuin, Lucia L. Prieto-Godino, Haiyun Pan, Craig Gutierrez, Lan Huang, Rongsheng Jin and Richard Benton

    Citation: BMC Biology 2019 17:34

    Content type: Research article

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  14. Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiolo...

    Authors: Lawrance Chandra, Dana C. Borcherding, Dawn Kingsbury, Todd Atherly, Yoko M. Ambrosini, Agnes Bourgois-Mochel, Wang Yuan, Michael Kimber, Yijun Qi, Qun Wang, Michael Wannemuehler, N. Matthew Ellinwood, Elizabeth Snella, Martin Martin, Melissa Skala, David Meyerholz…

    Citation: BMC Biology 2019 17:33

    Content type: Research article

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  15. Epigenetic mechanisms play fundamental roles in brain function and behavior and stressors such as social isolation can alter animal behavior via epigenetic mechanisms. However, due to cellular heterogeneity, i...

    Authors: Pavan Agrawal, Phuong Chung, Ulrike Heberlein and Clement Kent

    Citation: BMC Biology 2019 17:30

    Content type: Research article

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  17. Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as...

    Authors: Vanessa R. Marcelino, Michelle Wille, Aeron C. Hurt, Daniel González-Acuña, Marcel Klaassen, Timothy E. Schlub, John-Sebastian Eden, Mang Shi, Jonathan R. Iredell, Tania C. Sorrell and Edward C. Holmes

    Citation: BMC Biology 2019 17:31

    Content type: Research article

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  18. The processing of optic flow in the pretectum/accessory optic system allows animals to stabilize retinal images by executing compensatory optokinetic and optomotor behavior. The success of this behavior depend...

    Authors: Kun Wang, Julian Hinz, Väinö Haikala, Dierk F. Reiff and Aristides B. Arrenberg

    Citation: BMC Biology 2019 17:29

    Content type: Research article

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  19. Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The...

    Authors: Hak-Min Kim, Jessica A. Weber, Nayoung Lee, Seung Gu Park, Yun Sung Cho, Youngjune Bhak, Nayun Lee, Yeonsu Jeon, Sungwon Jeon, Victor Luria, Amir Karger, Marc W. Kirschner, Ye Jin Jo, Seonock Woo, Kyoungsoon Shin, Oksung Chung…

    Citation: BMC Biology 2019 17:28

    Content type: Research article

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  21. Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journa...

    Authors: Michael P. Milham and Arno Klein

    Citation: BMC Biology 2019 17:27

    Content type: Comment

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  22. Upon publication of the original article [1], the authors noticed that they omitted Additional file 16: Table S10 from the Additional file list. Additional file 16: Table S10 can be found attached to this Corr...

    Authors: Zhibo Cui, Aizi Tong, Yiqiong Huo, Zhiqiang Yan, Wenqi Yang, Xianli Yang and Xiao-Xue Wang

    Citation: BMC Biology 2019 17:25

    Content type: Correction

    Published on:

    The original article was published in BMC Biology 2017 15:80

  23. The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and...

    Authors: Basten L. Snoek, Rita J. M. Volkers, Harm Nijveen, Carola Petersen, Philipp Dirksen, Mark G. Sterken, Rania Nakad, Joost A. G. Riksen, Philip Rosenstiel, Jana J. Stastna, Bart P. Braeckman, Simon C. Harvey, Hinrich Schulenburg and Jan E. Kammenga

    Citation: BMC Biology 2019 17:24

    Content type: Research article

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  24. Female mammals have a limited reproductive lifespan determined by the size of the primordial follicle pool established perinatally. Over two thirds of fetal oocytes are abolished via programmed cell death duri...

    Authors: Jia Wen, Hao Yan, Meina He, Tuo Zhang, Xinyi Mu, Haibin Wang, Hua Zhang, Guoliang Xia and Chao Wang

    Citation: BMC Biology 2019 17:23

    Content type: Research article

    Published on:

  25. Although the overall brain organization is shared in vertebrates, there are significant differences within subregions among different groups, notably between Sarcopterygii (lobe-finned fish) and Actinopterygii...

    Authors: Solal Bloch, Manon Thomas, Ingrid Colin, Sonya Galant, Elodie Machado, Pierre Affaticati, Arnim Jenett and Kei Yamamoto

    Citation: BMC Biology 2019 17:22

    Content type: Research article

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  27. Microbial communities are susceptible to the public goods dilemma, whereby individuals can gain an advantage within a group by utilizing, but not sharing the cost of producing, public goods. In bacteria, the d...

    Authors: Kelei Zhao, Linjie Liu, Xiaojie Chen, Ting Huang, Lianming Du, Jiafu Lin, Yang Yuan, Yingshun Zhou, Bisong Yue, Kun Wei and Yiwen Chu

    Citation: BMC Biology 2019 17:20

    Content type: Research article

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  28. Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species ca...

    Authors: Courtney W. Stairs, Anna Kokla, Ásgeir Ástvaldsson, Jon Jerlström-Hultqvist, Staffan Svärd and Thijs J. G. Ettema

    Citation: BMC Biology 2019 17:19

    Content type: Research article

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  29. Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelm...

    Authors: Antony P. Page, Mark Roberts, Marie-Anne Félix, Derek Pickard, Andrew Page and William Weir

    Citation: BMC Biology 2019 17:10

    Content type: Research article

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  30. Farmers around the world have recently experienced significant crop losses due to severe heat and drought. Such extreme weather events and the need to feed a rapidly growing population have raised concerns for...

    Authors: Kai P. Voss-Fels, Andreas Stahl and Lee T. Hickey

    Citation: BMC Biology 2019 17:18

    Content type: Question and Answer

    Published on:

  31. Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shape...

    Authors: Timothy E. Saunders and Philip W. Ingham

    Citation: BMC Biology 2019 17:17

    Content type: Comment

    Published on:

  32. Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminth...

    Authors: Gregory A. Cary, Andrew Wolff, Olga Zueva, Joseph Pattinato and Veronica F. Hinman

    Citation: BMC Biology 2019 17:16

    Content type: Research article

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  33. A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 tha...

    Authors: Nicholas J. Gay

    Citation: BMC Biology 2019 17:15

    Content type: Commentary

    Published on:

    The original article was published in BMC Biology 2018 16:149

  34. Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in...

    Authors: Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P. Ponting, Eric A. Miska and Wilfried Haerty

    Citation: BMC Biology 2019 17:14

    Content type: Research article

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  36. Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition. Unli...

    Authors: Ginger L. Hunter, Li He, Norbert Perrimon, Guillaume Charras, Edward Giniger and Buzz Baum

    Citation: BMC Biology 2019 17:12

    Content type: Research article

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  37. Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gr...

    Authors: ThankGod E. Ebenezer, Martin Zoltner, Alana Burrell, Anna Nenarokova, Anna M. G. Novák Vanclová, Binod Prasad, Petr Soukal, Carlos Santana-Molina, Ellis O’Neill, Nerissa N. Nankissoor, Nithya Vadakedath, Viktor Daiker, Samson Obado, Sara Silva-Pereira, Andrew P. Jackson, Damien P. Devos…

    Citation: BMC Biology 2019 17:11

    Content type: Research article

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  38. CRISPR-Cas12a (formerly Cpf1) is an RNA-guided endonuclease with distinct features that have expanded genome editing capabilities. Cas12a-mediated genome editing is temperature sensitive in plants, but a lack ...

    Authors: Aimee A. Malzahn, Xu Tang, Keunsub Lee, Qiurong Ren, Simon Sretenovic, Yingxiao Zhang, Hongqiao Chen, Minjeong Kang, Yu Bao, Xuelian Zheng, Kejun Deng, Tao Zhang, Valeria Salcedo, Kan Wang, Yong Zhang and Yiping Qi

    Citation: BMC Biology 2019 17:9

    Content type: Research article

    Published on:

  39. In socially monogamous species, reproduction is not always confined to paired males and females. Extra-pair males commonly also reproduce with paired females, which is traditionally thought to be costly to the...

    Authors: Aneesh P. H. Bose, Jonathan M. Henshaw, Holger Zimmermann, Karoline Fritzsche and Kristina M. Sefc

    Citation: BMC Biology 2019 17:2

    Content type: Research article

    Published on:

  40. Photosynthesis and nitrogen fixation became evolutionarily immutable as “frozen metabolic accidents” because multiple interactions between the proteins and protein complexes involved led to their co-evolution ...

    Authors: Dario Leister

    Citation: BMC Biology 2019 17:8

    Content type: Review

    Published on:

  41. The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), especially those that are multidrug resistant poses a serious threat to global tuberculosis control. However, the mechanism underlying ...

    Authors: Lianhua Qin, Jie Wang, Junmei Lu, Hua Yang, Ruijuan Zheng, Zhonghua Liu, Xiaochen Huang, Yonghong Feng, Zhongyi Hu and Baoxue Ge

    Citation: BMC Biology 2019 17:7

    Content type: Research article

    Published on:

  42. Sex determination mechanisms in teleost fish broadly differ from mammals and birds, with sex chromosomes that are far less differentiated and recombination often occurring along the length of the X and Y chrom...

    Authors: Lisui Bao, Changxu Tian, Shikai Liu, Yu Zhang, Ahmed Elaswad, Zihao Yuan, Karim Khalil, Fanyue Sun, Yujia Yang, Tao Zhou, Ning Li, Suxu Tan, Qifan Zeng, Yang Liu, Yueru Li, Yun Li…

    Citation: BMC Biology 2019 17:6

    Content type: Research article

    Published on:

  43. RNA localization involves cis-motifs that are recognized by RNA-binding proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA localization is critical for many different ce...

    Authors: Sarah A. Middleton, James Eberwine and Junhyong Kim

    Citation: BMC Biology 2019 17:5

    Content type: Research article

    Published on:

  44. Recent genome studies of modern and ancient samples have proposed that Native Americans derive from a subset of the Eurasian gene pool carried to America by an ancestral Beringian population, from which two we...

    Authors: Viola Grugni, Alessandro Raveane, Linda Ongaro, Vincenza Battaglia, Beniamino Trombetta, Giulia Colombo, Marco Rosario Capodiferro, Anna Olivieri, Alessandro Achilli, Ugo A. Perego, Jorge Motta, Maribel Tribaldos, Scott R. Woodward, Luca Ferretti, Fulvio Cruciani, Antonio Torroni…

    Citation: BMC Biology 2019 17:3

    Content type: Research article

    Published on:

  45. Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regula...

    Authors: Alba Carreras, Luna Simona Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz M. Mayr, Rosie Perkins…

    Citation: BMC Biology 2019 17:4

    Content type: Research article

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  46. Current mesoscale 3D imaging techniques are limited to transparent or cleared samples or require the use of X-rays. This is a severe limitation for many research areas, as the 3D color surface morphology of op...

    Authors: Axelle Kerstens, Nikky Corthout, Benjamin Pavie, Zengjin Huang, Frank Vernaillen, Greetje Vande Velde and Sebastian Munck

    Citation: BMC Biology 2019 17:1

    Content type: Methodology article

    Published on:

  47. Cultured human cells are pivotal models to study human gene functions, but introducing complete loss of function in diploid or aneuploid cells has been a challenge. The recently developed CRISPR/Cas9-mediated ...

    Authors: Chenzi Zhang, Xiangjun He, Yvonne K. Kwok, Feng Wang, Junyi Xue, Hui Zhao, Kin Wah Suen, Chi Chiu Wang, Jianwei Ren, George G. Chen, Paul B. S. Lai, Jiangchao Li, Yin Xia, Andrew M. Chan, Wai-Yee Chan and Bo Feng

    Citation: BMC Biology 2018 16:151

    Content type: Methodology article

    Published on:

  48. Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the eff...

    Authors: Matthew A. Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta, Jonathan D. Wrigley, Maria Emanuela Cuomo, Marcello Maresca and Benjamin J. M. Taylor

    Citation: BMC Biology 2018 16:150

    Content type: Methodology article

    Published on:

  49. Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recog...

    Authors: Ailís O’Carroll, Brieuc Chauvin, James W. P. Brown, Ava Meagher, Joanne Coyle, Jurgen Schill, Akshay Bhumkhar, Dominic J. B. Hunter, Thomas Ve, Bostjan Kobe, Emma Sierecki and Yann Gambin

    Citation: BMC Biology 2018 16:149

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Biology 2019 17:15

  50. Many physiological processes in our body are controlled by the biological clock and show circadian rhythmicity. It is generally accepted that a robust rhythm is a prerequisite for optimal functioning and that ...

    Authors: Christian Tudorache, Hans Slabbekoorn, Yuri Robbers, Eline Hin, Johanna H. Meijer, Herman P. Spaink and Marcel J. M. Schaaf

    Citation: BMC Biology 2018 16:148

    Content type: Research article

    Published on:

Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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