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  1. Viviparity—live birth—is a complex and innovative mode of reproduction that has evolved repeatedly across the vertebrate Tree of Life. Viviparous species exhibit remarkable levels of reproductive diversity, bo...

    Authors: Rhiannon V. Eastment, Bob B. M. Wong and Matthew D. McGee
    Citation: BMC Biology 2024 22:34
  2. Ribosomal protein SA (RPSA) of human brain microvascular endothelial cells (HBMECs) can transfer from the cytosol to the cell surface and act as a receptor for some pathogens, including Streptococcus suis serotyp...

    Authors: Hexiang Jiang, Yi Sun, Fengyang Li, Xibing Yu, Siyu Lei, Sulan Du, Tong Wu, Xuan Jiang, Junhui Zhu, Jun Wang, Yalu Ji, Na Li, Xin Feng, Jingmin Gu, Wenyu Han, Lei Zeng…
    Citation: BMC Biology 2024 22:33
  3. The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which cause extreme virulence in chicken and human. ...

    Authors: Jiaxiang Hu, Linfei Song, Mengfei Ning, Xinyu Niu, Mengying Han, Chuze Gao, Xingwei Feng, Han Cai, Te Li, Fangtao Li, Huifang Li, Daoqing Gong, Weitao Song, Long Liu, Juan Pu, Jinhua Liu…
    Citation: BMC Biology 2024 22:31
  4. Despite the increasing number of epigenomic studies in plants, little is known about the forces that shape the methylome in long-lived woody perennials. The Lombardy poplar offers an ideal opportunity to inves...

    Authors: An Vanden Broeck, Tim Meese, Pieter Verschelde, Karen Cox, Berthold Heinze, Dieter Deforce, Ellen De Meester and Filip Van Nieuwerburgh
    Citation: BMC Biology 2024 22:30
  5. Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) cha...

    Authors: Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao and Ping Li
    Citation: BMC Biology 2024 22:29
  6. The human brain can rapidly represent sets of similar stimuli by their ensemble summary statistics, like the average orientation or size. Classic models assume that ensemble statistics are computed by integrat...

    Authors: Natalia A. Tiurina, Yuri A. Markov, David Whitney and David Pascucci
    Citation: BMC Biology 2024 22:28
  7. Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and me...

    Authors: E. C. Solar Venero, M. B. Galeano, A. Luqman, M. M. Ricardi, F. Serral, D. Fernandez Do Porto, S. A. Robaldi, B. A. Z. Ashari, T. H. Munif, D. E. Egoburo, S. Nemirovsky, J. Escalante, B. Nishimura, M. S. Ramirez, F. Götz and P. M. Tribelli
    Citation: BMC Biology 2024 22:27
  8. The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of genetically altered knock-in mice via CRISPR-Cas9. ...

    Authors: Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley and Benjamin Davies
    Citation: BMC Biology 2024 22:26
  9. Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM is so difficult to treat is that it is highly infiltrative. Migrasomes are newly discovered membrane ...

    Authors: Seon Yong Lee, Sang-Hun Choi, Yoonji Kim, Hee-Sung Ahn, Young-Gyu Ko, Kyunggon Kim, Sung Wook Chi and Hyunggee Kim
    Citation: BMC Biology 2024 22:23
  10. Fungal plant pathogens have dynamic genomes that allow them to rapidly adapt to adverse conditions and overcome host resistance. One way by which this dynamic genome plasticity is expressed is through effector...

    Authors: Alex Z. Zaccaron and Ioannis Stergiopoulos
    Citation: BMC Biology 2024 22:25
  11. Circular RNAs (circRNAs) have been confirmed to play a vital role in the occurrence and development of diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significance for stu...

    Authors: Mengting Niu, Chunyu Wang, Zhanguo Zhang and Quan Zou
    Citation: BMC Biology 2024 22:24
  12. Hematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed to acquire nutrients for reproduction. The midgut epith...

    Authors: M. L. Taracena-Agarwal, B. Hixson, S. Nandakumar, A. P. Girard-Mejia, R. Y. Chen, L. Huot, N. Padilla and N. Buchon
    Citation: BMC Biology 2024 22:22
  13. The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South...

    Authors: Guanglin He, Peixin Wang, Jing Chen, Yan Liu, Yuntao Sun, Rong Hu, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Libing Yun, Liping Hu, Jiangwei Yan, Shengjie Nie, Lanhai Wei…
    Citation: BMC Biology 2024 22:18
  14. Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk ti...

    Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk and Jonathan Mill
    Citation: BMC Biology 2024 22:17
  15. Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differ...

    Authors: Sergei S. Ryazansky, Chujia Chen, Mark Potters, Anastasia N. Naumenko, Varvara Lukyanchikova, Reem A. Masri, Ilya I. Brusentsov, Dmitriy A. Karagodin, Andrey A. Yurchenko, Vitor L. dos Anjos, Yuki Haba, Noah H. Rose, Jinna Hoffman, Rong Guo, Theresa Menna, Melissa Kelley…
    Citation: BMC Biology 2024 22:16
  16. Mosquito borne viruses, such as dengue, Zika, yellow fever and Chikungunya, cause millions of infections every year. These viruses are mostly transmitted by two urban-adapted mosquito species, Aedes aegypti and A...

    Authors: Carlos F. Estevez-Castro, Murillo F. Rodrigues, Antinéa Babarit, Flávia V. Ferreira, Elisa G. de Andrade, Eric Marois, Rodrigo Cogni, Eric R. G. R. Aguiar, João T. Marques and Roenick P. Olmo
    Citation: BMC Biology 2024 22:14
  17. Single-nucleotide polymorphisms (SNPs) are the most widely used form of molecular genetic variation studies. As reference genomes and resequencing data sets expand exponentially, tools must be in place to call...

    Authors: Yong Zhou, Nagarajan Kathiresan, Zhichao Yu, Luis F. Rivera, Yujian Yang, Manjula Thimma, Keerthana Manickam, Dmytro Chebotarov, Ramil Mauleon, Kapeel Chougule, Sharon Wei, Tingting Gao, Carl D. Green, Andrea Zuccolo, Weibo Xie, Doreen Ware…
    Citation: BMC Biology 2024 22:13
  18. Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...

    Authors: Huazhang Zhu, Dawei Wang, Zuodong Ye, Lihong Huang, Wenjie Wei, Kui Ming Chan, Rongxin Zhang, Liang Zhang and Jianbo Yue
    Citation: BMC Biology 2024 22:12
  19. The remarkable resistance to ionizing radiation found in anhydrobiotic organisms, such as some bacteria, tardigrades, and bdelloid rotifers has been hypothesized to be incidental to their desiccation resistanc...

    Authors: Victoria C. Moris, Lucie Bruneau, Jérémy Berthe, Anne-Catherine Heuskin, Sébastien Penninckx, Sylvia Ritter, Uli Weber, Marco Durante, Etienne G. J. Danchin, Boris Hespeels and Karine Van Doninck
    Citation: BMC Biology 2024 22:11
  20. Dimorphism, the ability to switch between a ‘yeast-like’ and a hyphal growth form, is an important feature of certain fungi, including important plant and human pathogens. The switch to hyphal growth is often ...

    Authors: Andrea Kovács-Simon and Helen N. Fones
    Citation: BMC Biology 2024 22:10
  21. How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processe...

    Authors: Jessica A. Goodheart, Robin A. Rio, Neville F. Taraporevala, Rose A. Fiorenza, Seth R. Barnes, Kevin Morrill, Mark Allan C. Jacob, Carl Whitesel, Park Masterson, Grant O. Batzel, Hereroa T. Johnston, M. Desmond Ramirez, Paul S. Katz and Deirdre C. Lyons
    Citation: BMC Biology 2024 22:9
  22. Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment.

    Authors: Tengfei Lu, Yannan Ji, Mengmeng Chang, Xiaoming Zhang, Yanhong Wang and Zhen Zou
    Citation: BMC Biology 2024 22:7
  23. Precise gene targeting (GT) is a powerful tool for heritable precision genome engineering, enabling knock-in or replacement of the endogenous sequence via homologous recombination. We recently established a CR...

    Authors: Jing Li, Dali Kong, Yongping Ke, Wenjie Zeng and Daisuke Miki
    Citation: BMC Biology 2024 22:6
  24. SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets agains...

    Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer and Katrin Paeschke
    Citation: BMC Biology 2024 22:5
  25. The common carp (Cyprinus carpio) might best represent the domesticated allopolyploid animals. Although subgenome divergence which is well-known to be a key to allopolyploid domestication has been comprehensively...

    Authors: Min Wang, Xinxin Li, Chongnv Wang, Ming Zou, Jing Yang, Xiang-dong Li and Baocheng Guo
    Citation: BMC Biology 2024 22:4
  26. Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and...

    Authors: Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson and Helen L. Fitzsimons
    Citation: BMC Biology 2024 22:2
  27. Cell senescence is a sign of aging and plays a significant role in the pathogenesis of age-related disorders. For cell therapy, senescence may compromise the quality and efficacy of cells, posing potential saf...

    Authors: Liangge He, Mingzhu Li, Xinglie Wang, Xiaoyan Wu, Guanghui Yue, Tianfu Wang, Yan Zhou, Baiying Lei and Guangqian Zhou
    Citation: BMC Biology 2024 22:1
  28. The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose questions on how much is currently known ab...

    Authors: Lydia Teboul, Yann Hérault, Sara Wells and Guillaume Pavlovic
    Citation: BMC Biology 2023 21:301
  29. Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D organoid cultures in non-model animals, such as dogs....

    Authors: Karin Allenspach, Yana Zavros, Mohamed Elbadawy, Christopher Zdyrski and Jonathan Paul Mochel
    Citation: BMC Biology 2023 21:297
  30. Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics...

    Authors: Margherita De Marzio, Kimberly Glass and Marieke L. Kuijjer
    Citation: BMC Biology 2023 21:296
  31. Identifying the key factors that underlie complex traits during domestication is a great challenge for evolutionary and biological studies. In addition to the protein-coding region differences caused by varian...

    Authors: Zhong-Tao Yin, Xiao-Qin Li, Yun-Xiao Sun, Jacqueline Smith, Maxwell Hincke, Ning Yang and Zhuo-Cheng Hou
    Citation: BMC Biology 2023 21:303
  32. Alzheimer’s disease (AD) is the most common neurodegenerative disorder with clinical presentations of progressive cognitive and memory deterioration. The pathologic hallmarks of AD include tau neurofibrillary ...

    Authors: Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin and Shu-Chun Teng
    Citation: BMC Biology 2023 21:293
  33. Olfactory sensory neurons detect odourants via multiple long cilia that protrude from their dendritic endings. The G protein-coupled receptor GPRC5C was identified as part of the olfactory ciliary membrane pro...

    Authors: Sneha Bhat, André Dietz, Katja Senf, Sandor Nietzsche, Yoshio Hirabayashi, Martin Westermann and Eva Maria Neuhaus
    Citation: BMC Biology 2023 21:292
  34. Rhabdomeric photoreceptors of eyes in the terrestrial slug Limax are the typical invertebrate-type but unique in that three visual opsins (Gq-coupled rhodopsin, xenopsin, Opn5A) and one retinochrome, all belongin...

    Authors: Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo and Akihisa Terakita
    Citation: BMC Biology 2023 21:291
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