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  1. Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and ...

    Authors: Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li and Valerie C. L. Lin
    Citation: BMC Biology 2022 20:222
  2. Feature-based attention prioritizes the processing of the attended feature while strongly suppressing the processing of nearby ones. This creates a non-linearity or “attentional suppressive surround” predicted...

    Authors: Sang-Ah Yoo, Julio C. Martinez-Trujillo, Stefan Treue, John K. Tsotsos and Mazyar Fallah
    Citation: BMC Biology 2022 20:220
  3. Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such a...

    Authors: Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali and Denis Vivien
    Citation: BMC Biology 2022 20:218
  4. Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerizatio...

    Authors: Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet and Isabelle M. L. Billas
    Citation: BMC Biology 2022 20:217
  5. Eudicots are the most diverse group of flowering plants that compromise five well-defined lineages: core eudicots, Ranunculales, Proteales, Trochodendrales, and Buxales. However, the phylogenetic relationships...

    Authors: Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu and Yongzhi Yang
    Citation: BMC Biology 2022 20:216
  6. Although the wild relatives of pear originated in southwest China, this fruit crop was independently domesticated and improved in Asia and Europe, and there are major phenotypic differences (e.g., maturity and...

    Authors: Bobo Song, Xiaolong Li, Beibei Cao, Mingyue Zhang, Schuyler S. Korban, Li’ang Yu, Wenxi Yang, Kejiao Zhao, Jiaming Li and Jun Wu
    Citation: BMC Biology 2022 20:215
  7. Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or...

    Authors: Xiao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo, Xin-Lin Gong and Chen-Zhu Wang
    Citation: BMC Biology 2022 20:214
  8. Prevalent single-cell transcriptomic profiling (scRNA-seq) methods are mainly based on the synthesis and enrichment of full-length double-stranded complementary DNA. These approaches are challenging to generat...

    Authors: Lin Di, Bo Liu, Yuzhu Lyu, Shihui Zhao, Yuhong Pang, Chen Zhang, Jianbin Wang, Hai Qi, Jie Shen and Yanyi Huang
    Citation: BMC Biology 2022 20:213
  9. Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial q...

    Authors: Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen and Petra Knaus
    Citation: BMC Biology 2022 20:210
  10. SWI/SNF (BAF) chromatin remodeling complexes regulate lineage-specific enhancer activity by promoting accessibility for diverse DNA-binding factors and chromatin regulators. Additionally, they are known to mod...

    Authors: Jake J. Reske, Mike R. Wilson, Brooke Armistead, Shannon Harkins, Cristina Perez, Joel Hrit, Marie Adams, Scott B. Rothbart, Stacey A. Missmer, Asgerally T. Fazleabas and Ronald L. Chandler
    Citation: BMC Biology 2022 20:209
  11. Starch, a vital plant-derived polysaccharide comprised of branched glucans, is essential in nutrition and many industrial applications. Starch is often modified post-extraction to alter its structure and enhan...

    Authors: Barbara Pfister, Jessica M. Shields, Tobias Kockmann, Jonas Grossmann, Melanie R. Abt, Martha Stadler and Samuel C. Zeeman
    Citation: BMC Biology 2022 20:207
  12. Giardia lamblia, a parasitic protist of the Metamonada supergroup, has evolved one of the most diverged endocytic compartment systems investigated so far. Peripheral endocytic compartments, currently known as pe...

    Authors: Rui Santos, Ásgeir Ástvaldsson, Shweta V. Pipaliya, Jon Paulin Zumthor, Joel B. Dacks, Staffan Svärd, Adrian B. Hehl and Carmen Faso
    Citation: BMC Biology 2022 20:206
  13. Oxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved in modulating multiple sensory information processing pathways, and its roles in the brain have been associate...

    Authors: Songhui Hu, Yurong Wang, Xu Han, Min Dai, Yongxing Zhang, Yuanyuan Ma, Shijun Weng and Lei Xiao
    Citation: BMC Biology 2022 20:205
  14. B chromosomes are extra elements found in several eukaryote species. Usually, they do not express a phenotype in the host. However, advances in bioinformatics over the last decades have allowed us to describe ...

    Authors: Jordana Inácio Nascimento Oliveira, Adauto Lima Cardoso, Ivan Rodrigo Wolf, Rogério Antônio de Oliveira and Cesar Martins
    Citation: BMC Biology 2022 20:204
  15. In recent years, Precambrian lifeforms have generated an ever-increasing interest because they revealed a rich eukaryotic diversity prior to the Cambrian explosion of modern animals. Among them, macroalgae are...

    Authors: Shu Chai, Cédric Aria and Hong Hua
    Citation: BMC Biology 2022 20:199
  16. To disperse in water-unsaturated environments, such as the soil, bacteria rely on the availability and structure of water films forming on biotic and abiotic surfaces, and, especially, along fungal mycelia. Di...

    Authors: Thierry Kuhn, Matteo Buffi, Saskia Bindschedler, Patrick S. Chain, Diego Gonzalez, Claire E. Stanley, Lukas Y. Wick, Pilar Junier and Xiang-Yi Li Richter
    Citation: BMC Biology 2022 20:203
  17. Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these mechanisms are not well studied in non-model organisms. Unique features of cephalopods make them attractive for investigating...

    Authors: Filippo Macchi, Eric Edsinger and Kirsten C. Sadler
    Citation: BMC Biology 2022 20:202
  18. Nitrogen is considered the most limiting nutrient element for herbivorous insects. To alleviate nitrogen limitation, insects have evolved various symbiotically mediated strategies that enable them to colonize ...

    Authors: Xueming Ren, Shuai Cao, Mazarin Akami, Abdelaziz Mansour, Yishi Yang, Nan Jiang, Haoran Wang, Guijian Zhang, Xuewei Qi, Penghui Xu, Tong Guo and Changying Niu
    Citation: BMC Biology 2022 20:201
  19. Interspecific postzygotic reproduction isolation results from large genetic divergence between the subgenomes of established hybrids. Polyploidization immediately after hybridization may reset patterns of homo...

    Authors: Li Ren, Xin Gao, Jialin Cui, Chun Zhang, He Dai, Mengxue Luo, Shaofang He, Qinbo Qin, Kaikun Luo, Min Tao, Jun Xiao, Jing Wang, Hong Zhang, Xueyin Zhang, Yi Zhou, Jing Wang…
    Citation: BMC Biology 2022 20:200
  20. Drosophila melanogaster lipophorin receptors (LpRs), LpR1 and LpR2, are members of the LDLR family known to mediate lipid uptake in a range of organisms from Drosophila to humans. The vertebrate orthologs of LpRs...

    Authors: Francisca Rojo-Cortés, Nicolás Fuenzalida-Uribe, Victoria Tapia-Valladares, Candy B. Roa, Sergio Hidalgo, María-Constanza González-Ramírez, Carlos Oliva, Jorge M. Campusano and María-Paz Marzolo
    Citation: BMC Biology 2022 20:198
  21. Little is known about how normal variation in dietary patterns in humans affects the ageing process. To date, most analyses of the problem have used a unidimensional paradigm, being concerned with the effects ...

    Authors: Alistair M. Senior, Véronique Legault, Francis B. Lavoie, Nancy Presse, Pierrette Gaudreau, Valérie Turcot, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson and Alan A. Cohen
    Citation: BMC Biology 2022 20:196
  22. Ray-finned fishes (Actinopterygii) perceive their environment through a range of sensory modalities, including olfaction. Anatomical diversity of the olfactory organ suggests that olfaction is differentially i...

    Authors: Maxime Policarpo, Katherine E. Bemis, Patrick Laurenti, Laurent Legendre, Jean-Christophe Sandoz, Sylvie Rétaux and Didier Casane
    Citation: BMC Biology 2022 20:195
  23. Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability. Recent data s...

    Authors: Giuseppa Grasso, Charbel Akkawi, Celine Franckhauser, Rima Nait-Saidi, Maxime Bello, Jérôme Barbier and Rosemary Kiernan
    Citation: BMC Biology 2022 20:194
  24. Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) and t...

    Authors: Jenifer Vallejo, Ryosuke Saigusa, Rishab Gulati, Sujit Silas Armstrong Suthahar, Vasantika Suryawanshi, Ahmad Alimadadi, Christopher P. Durant, Yanal Ghosheh, Payel Roy, Erik Ehinger, Tanyaporn Pattarabanjird, David B. Hanna, Alan L. Landay, Russell P. Tracy, Jason M. Lazar, Wendy J. Mack…
    Citation: BMC Biology 2022 20:193

    The Correction to this article has been published in BMC Biology 2022 20:237

  25. In a time of rapid environmental change, understanding how the challenges experienced by one generation can influence the fitness of future generations is critically needed. Using tolerance assays and transcri...

    Authors: Alexandria Ragsdale, Oscar Ortega-Recalde, Ludovic Dutoit, Anne A. Besson, Jolyn H. Z. Chia, Tania King, Shinichi Nakagawa, Anthony Hickey, Neil J. Gemmell, Timothy Hore and Sheri L. Johnson
    Citation: BMC Biology 2022 20:185
  26. It has been known for centuries that cats respond euphorically to Nepeta cataria (catnip). Recently, we have shown that Lonicera tatarica (Tatarian honeysuckle), Actinidia polygama (silver vine), and Valeriana of...

    Authors: Sebastiaan Bol, Adrian Scaffidi, Evelien M. Bunnik and Gavin R. Flematti
    Citation: BMC Biology 2022 20:192
  27. Biological invasions are responsible for substantial environmental and economic losses. The red turpentine beetle (RTB), Dendroctonus valens LeConte, is an important invasive bark beetle from North America that h...

    Authors: Zhudong Liu, Longsheng Xing, Wanlong Huang, Bo Liu, Fanghao Wan, Kenneth F. Raffa, Richard W. Hofstetter, Wanqiang Qian and Jianghua Sun
    Citation: BMC Biology 2022 20:190
  28. T cell activation leads to increased expression of the receptor for the iron transporter transferrin (TfR) to provide iron required for the cell differentiation and clonal expansion that takes place during the...

    Authors: Pascal Rossatti, Gregory M. I. Redpath, Luca Ziegler, Guerric P. B. Samson, Camille D. Clamagirand, Daniel F. Legler and Jérémie Rossy
    Citation: BMC Biology 2022 20:189
  29. The blue-crowned laughingthrush (Garrulax courtoisi) is a critically endangered songbird endemic to Wuyuan, China, with population of ~323 individuals. It has attracted widespread attention, but the lack of a pub...

    Authors: Hao Chen, Min Huang, Daoqiang Liu, Hongbo Tang, Sumei Zheng, Jing Ouyang, Hui Zhang, Luping Wang, Keyi Luo, Yuren Gao, Yongfei Wu, Yan Wu, Yanpeng Xiong, Tao Luo, Yuxuan Huang, Rui Xiong…
    Citation: BMC Biology 2022 20:188
  30. Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus. Phylogeneti...

    Authors: Nayeli Escudero Castelán, Dean C. Semmens, Luis Alfonso Yañez Guerra, Meet Zandawala, Mario dos Reis, Susan E. Slade, James H. Scrivens, Cleidiane G. Zampronio, Alexandra M. Jones, Olivier Mirabeau and Maurice R. Elphick
    Citation: BMC Biology 2022 20:187
  31. Karat (Musa troglodytarum L.) is an autotriploid Fe’i banana of the Australimusa section. Karat was domesticated independently in the Pacific region, and karat fruit are characterized by a pink sap, a deep yellow...

    Authors: Zhiying Li, Jiabin Wang, Yunliu Fu, Yonglin Jing, Bilan Huang, Ying Chen, Qinglong Wang, Xiao Bing Wang, Chunyang Meng, Qingquan Yang and Li Xu
    Citation: BMC Biology 2022 20:186
  32. Chromatin-modifying proteins are key players in the regulation of development and cell differentiation in animals. Most chromatin modifiers, however, predate the evolution of animal multicellularity, and how t...

    Authors: James M. Gahan, Lucas Leclère, Maria Hernandez-Valladares and Fabian Rentzsch
    Citation: BMC Biology 2022 20:184
  33. Efficient tools allowing the extraction of 2D surfaces from 3D-microscopy data are essential for studies aiming to decipher the complex cellular choreography through which epithelium morphogenesis takes place ...

    Authors: Céline Trébeau, Jacques Boutet de Monvel, Gizem Altay, Jean-Yves Tinevez and Raphaël Etournay
    Citation: BMC Biology 2022 20:183
  34. SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role...

    Authors: Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, Heather P. O’Keefe, Aaron Coffin, Amish Patel, Lisa A. Sloan, Darren J. Mitchell, Thomas G. Hayhow…
    Citation: BMC Biology 2022 20:182
  35. The mitochondrion is an important cellular component in plants and that functions in producing vital energy for the cell. However, the evolution and structure of mitochondrial genomes (mitogenomes) remain uncl...

    Authors: Manyi Sun, Mingyue Zhang, Xuening Chen, Yueyuan Liu, Binbin Liu, Jiaming Li, Runze Wang, Kejiao Zhao and Jun Wu
    Citation: BMC Biology 2022 20:181
  36. Buoyancy and balance are important parameters for slow-moving, low-metabolic, aquatic organisms. The extant coelacanths have among the lowest metabolic rates of any living vertebrate and can afford little ener...

    Authors: Henrik Lauridsen, Jens Mikkel Hyllested Pedersen, Steffen Ringgaard and Peter Rask Møller
    Citation: BMC Biology 2022 20:180
  37. Microscopy techniques and image segmentation algorithms have improved dramatically this decade, leading to an ever increasing amount of biological images and a greater reliance on imaging to investigate biolog...

    Authors: Gustave Ronteix, Andrey Aristov, Valentin Bonnet, Sebastien Sart, Jeremie Sobel, Elric Esposito and Charles N. Baroud
    Citation: BMC Biology 2022 20:178
  38. Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular...

    Authors: Pushpanjali Soppina, Nishaben Patel, Dipeshwari J. Shewale, Ashim Rai, Sivaraj Sivaramakrishnan, Pradeep K. Naik and Virupakshi Soppina
    Citation: BMC Biology 2022 20:177
  39. Calmodulin (CaM) is an evolutionarily conserved eukaryotic multifunctional protein that functions as the major sensor of intracellular calcium signaling. Its calcium-modulated function regulates the activity o...

    Authors: Corentin Léger, Irène Pitard, Mirko Sadi, Nicolas Carvalho, Sébastien Brier, Ariel Mechaly, Dorothée Raoux-Barbot, Maryline Davi, Sylviane Hoos, Patrick Weber, Patrice Vachette, Dominique Durand, Ahmed Haouz, J. Iñaki Guijarro, Daniel Ladant and Alexandre Chenal
    Citation: BMC Biology 2022 20:176
  40. Cyanobacteria are the major prokaryotic primary producers occupying a range of aquatic habitats worldwide that differ in levels of salinity, making them a group of interest to study one of the major unresolved...

    Authors: Pedro J. Cabello-Yeves, Cristiana Callieri, Antonio Picazo, Lena Schallenberg, Paula Huber, Juan J. Roda-Garcia, Maciej Bartosiewicz, Olga I. Belykh, Irina V. Tikhonova, Alberto Torcello-Requena, Paula Martin De Prado, Richard J. Puxty, Andrew D. Millard, Antonio Camacho, Francisco Rodriguez-Valera and David J. Scanlan
    Citation: BMC Biology 2022 20:175
  41. High-throughput live-cell imaging is a powerful tool to study dynamic cellular processes in single cells but creates a bottleneck at the stage of data analysis, due to the large amount of data generated and li...

    Authors: Francesco Padovani, Benedikt Mairhörmann, Pascal Falter-Braun, Jette Lengefeld and Kurt M. Schmoller
    Citation: BMC Biology 2022 20:174
  42. Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, whic...

    Authors: Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger and Olaf Rötzschke
    Citation: BMC Biology 2022 20:173
  43. ATP-dependent chromatin remodeling complexes are multi-protein machines highly conserved across eukaryotic genomes. They control sliding and displacing of the nucleosomes, modulating histone-DNA interactions a...

    Authors: Giovanni Messina, Yuri Prozzillo, Francesca Delle Monache, Maria Virginia Santopietro and Patrizio Dimitri
    Citation: BMC Biology 2022 20:172
  44. The high-mobility group Hmga family of proteins are non-histone chromatin-interacting proteins which have been associated with a number of nuclear functions, including heterochromatin formation, replication, r...

    Authors: Giuseppina Divisato, Andrea M. Chiariello, Andrea Esposito, Pietro Zoppoli, Federico Zambelli, Maria Antonietta Elia, Graziano Pesole, Danny Incarnato, Fabiana Passaro, Silvia Piscitelli, Salvatore Oliviero, Mario Nicodemi, Silvia Parisi and Tommaso Russo
    Citation: BMC Biology 2022 20:171