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  1. Immune cells that infiltrate lesions are important for atherosclerosis progression and immunotherapies. This study was aimed at gaining important new insights into the heterogeneity of these cells by integrati...

    Authors: Jie Xiong, Zhaoyue Li, Hao Tang, Yuchen Duan, Xiaofang Ban, Ke Xu, Yutong Guo and Yingfeng Tu
    Citation: BMC Biology 2023 21:46
  2. CRISPR-based screens are revolutionizing drug discovery as tools to identify genes whose ablation induces a phenotype of interest. For instance, CRISPR-Cas9 screening has been successfully used to identify nov...

    Authors: Byung-Sun Park, Heeju Jeon, Sung-Gil Chi and Tackhoon Kim
    Citation: BMC Biology 2023 21:45
  3. Perceptual learning refers to an augmentation of an organism’s ability to respond to external stimuli, which has been described in most sensory modalities. Visual perceptual learning (VPL) is a manifestation o...

    Authors: Zhenni Wang, Shihao Lou, Xiao Ma, Hui Guo, Yan Liu, Wenjing Chen, Dating Lin and Yupeng Yang
    Citation: BMC Biology 2023 21:44
  4. Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we foun...

    Authors: Shou-Bin Tang, Ting-Ting Zhang, Shen Yin, Wei Shen, Shi-Ming Luo, Yong Zhao, Cui-Lian Zhang, Francesca Gioia Klinger, Qing-Yuan Sun and Zhao-Jia Ge
    Citation: BMC Biology 2023 21:43
  5. Adaptation to high-altitude hypobaric hypoxia has been shown to require a set of physiological traits enabled by an associated set of genetic modifications, as well as transcriptome regulation. These lead to b...

    Authors: Huanping Guo, Lin Xia, Wei Wang, Wei Xu, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang and Yunfang Zhang
    Citation: BMC Biology 2023 21:39
  6. Although the extreme environmental adaptation of organisms is a hot topic in evolutionary biology, genetic adaptation to high-altitude environment remains poorly characterized in ectothermic animals. Squamates...

    Authors: Weiming Li, Juan Du, Lingyun Yang, Qiqi Liang, Mengyuan Yang, Xuming Zhou and Weiguo Du
    Citation: BMC Biology 2023 21:40
  7. Formula-fed infants are at increased risk of infections. Due to the cross-talk between the mucosal systems of the gastrointestinal and respiratory tracts, adding synbiotics (prebiotics and probiotics) to infan...

    Authors: Kotryna Simonyté Sjödin, Andreas Sjödin, Marek Ruszczyński, Mette Bach Kristensen, Olle Hernell, Hania Szajewska and Christina E. West
    Citation: BMC Biology 2023 21:38
  8. Amaranthus L. is a diverse genus consisting of domesticated, weedy, and non-invasive species distributed around the world. Nine species are dioecious, of which Amaranthus palmeri S. Watson and Amaranthus tubercul...

    Authors: Damilola A. Raiyemo, Lucas K. Bobadilla and Patrick J. Tranel
    Citation: BMC Biology 2023 21:37
  9. Cellular entry of SARS-CoV-2 has been shown to rely on angiotensin-converting enzyme 2 (ACE2) receptors, whose expression in the testis is among the highest in the body. Additionally, the risk of mortality see...

    Authors: Guilherme M. J. Costa, Samyra M. S. N. Lacerda, André F. A. Figueiredo, Natália T. Wnuk, Marcos R. G. Brener, Lídia M. Andrade, Gabriel H. Campolina-Silva, Andrea Kauffmann-Zeh, Lucila G. G. Pacifico, Alice F. Versiani, Maísa M. Antunes, Fernanda R. Souza, Geovanni D. Cassali, André L. Caldeira-Brant, Hélio Chiarini-Garcia, Fernanda G. de Souza…
    Citation: BMC Biology 2023 21:36
  10. Climate change is one of the main factors shaping the distribution and biodiversity of organisms, among others by greatly altering water availability, thus exposing species and ecosystems to harsh desiccation ...

    Authors: Vivien Horváth, Sara Guirao-Rico, Judit Salces-Ortiz, Gabriel E. Rech, Llewellyn Green, Eugenio Aprea, Mirco Rodeghiero, Gianfranco Anfora and Josefa González
    Citation: BMC Biology 2023 21:35
  11. Authors: Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li and Valerie C. L. Lin
    Citation: BMC Biology 2023 21:34

    The original article was published in BMC Biology 2022 20:222

  12. Pruning that selectively eliminates unnecessary or incorrect neurites is required for proper wiring of the mature nervous system. During Drosophila metamorphosis, dendritic arbourization sensory neurons (ddaCs) a...

    Authors: Shufeng Bu, Samuel Song Yuan Lau, Wei Lin Yong, Heng Zhang, Sasinthiran Thiagarajan, Arash Bashirullah and Fengwei Yu
    Citation: BMC Biology 2023 21:33
  13. Sex determination occurs across animal species, but most of our knowledge about its mechanisms comes from only a handful of bilaterian taxa. This limits our ability to infer the evolutionary history of sex det...

    Authors: Ruoxu Chen, Steven M. Sanders, Zhiwei Ma, Justin Paschall, E. Sally Chang, Brooke M. Riscoe, Christine E. Schnitzler, Andreas D. Baxevanis and Matthew L. Nicotra
    Citation: BMC Biology 2023 21:32
  14. Intracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle erythrocytes from sickle cell anemia (SCA) patients. However, the contributio...

    Authors: Kun Wang, Zhiqiang Li, Ogechukwu Egini, Raj Wadgaonkar, Xian-Cheng Jiang and Yong Chen
    Citation: BMC Biology 2023 21:31
  15. Aging is known to exert an effect on liver regeneration, with the ability of liver to regenerate displaying a significant decline over time. Liver physiological parameters such as liver volume, blood flow, and...

    Authors: Junying Wang, Wen Zhang, Xiaoqin Liu, Minjee Kim, Ke Zhang and Robert Y. L. Tsai
    Citation: BMC Biology 2023 21:30
  16. Worldwide wheat production is under constant threat by fast-evolving fungal pathogens. In the last decades, wheat breeding for disease resistance heavily relied on the introgression of chromosomal segments fro...

    Authors: Lukas Kunz, Alexandros G. Sotiropoulos, Johannes Graf, Mohammad Razavi, Beat Keller and Marion C. Müller
    Citation: BMC Biology 2023 21:29
  17. Pericentromeric regions of human chromosomes are composed of tandem-repeated and highly organized sequences named satellite DNAs. Human classical satellite DNAs are classified into three families named HSat1, ...

    Authors: Mariana Lopes, Sandra Louzada, Daniela Ferreira, Gabriela Veríssimo, Daniel Eleutério, Margarida Gama-Carvalho and Raquel Chaves
    Citation: BMC Biology 2023 21:28
  18. In addition to its contractile properties and role in movement, skeletal muscle plays an important function in regulating whole-body glucose and lipid metabolism. A central component of such regulation is mito...

    Authors: Wentao Chen, Ziye Xu, Wenjing You, Yanbing Zhou, Liyi Wang, Yuqin Huang and Tizhong Shan
    Citation: BMC Biology 2023 21:27
  19. Ponerine ants are almost exclusively predatory and comprise many of the largest known ant species. Within this clade, the genus Neoponera is among the most conspicuous Neotropical predators. We describe the first...

    Authors: Gianpiero Fiorentino, John Lattke, Adrian Troya, Christine Sosiak, Minsoo Dong and Phillip Barden
    Citation: BMC Biology 2023 21:26
  20. In 1975, the mummified body of a female has been found in the Franciscan church in Basel, Switzerland. Molecular and genealogic analyses unveiled her identity as Anna Catharina Bischoff (ACB), a member of the ...

    Authors: Mohamed S. Sarhan, Christina Wurst, Alexandar Tzankov, Andreas J. Bircher, Holger Wittig, Thomas Briellmann, Marc Augsburger, Gerhard Hotz, Albert Zink and Frank Maixner
    Citation: BMC Biology 2023 21:9
  21. Gene duplication is a prevalent phenomenon and a major driving force underlying genome evolution. The process leading to the fixation of gene duplicates following duplication is critical to understand how geno...

    Authors: Yong Jia, Mingrui Xu, Haifei Hu, Brett Chapman, Calum Watt, B. Buerte, Ning Han, Muyuan Zhu, Hongwu Bian, Chengdao Li and Zhanghui Zeng
    Citation: BMC Biology 2023 21:25
  22. Studying genomic variation in rapidly evolving pathogens potentially enables identification of genes supporting their “core biology”, being present, functional and expressed by all strains or “flexible biology...

    Authors: Hongxin Chen, Robert King, Dan Smith, Carlos Bayon, Tom Ashfield, Stefano Torriani, Kostya Kanyuka, Kim Hammond-Kosack, Stephane Bieri and Jason Rudd
    Citation: BMC Biology 2023 21:24
  23. Cancer heterogeneity is a main obstacle for the development of effective therapies, as its replication in in vitro preclinical models is challenging. Around 96% of developed drugs are estimated to fail from di...

    Authors: Antonella Raffo-Romero, Soulaimane Aboulouard, Emmanuel Bouchaert, Agata Rybicka, Dominique Tierny, Nawale Hajjaji, Isabelle Fournier, Michel Salzet and Marie Duhamel
    Citation: BMC Biology 2023 21:23
  24. Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment. Although the predominant cause of eye malformations ...

    Authors: Justine M. Chee, Louise Lanoue, Dave Clary, Kendall Higgins, Lynette Bower, Ann Flenniken, Ruolin Guo, David J. Adams, Fatima Bosch, Robert E. Braun, Steve D. M. Brown, H.-J. Genie Chin, Mary E. Dickinson, Chih-Wei Hsu, Michael Dobbie, Xiang Gao…
    Citation: BMC Biology 2023 21:22
  25. In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs i...

    Authors: Rebecca Sternke-Hoffmann, Thomas Pauly, Rasmus K. Norrild, Jan Hansen, Florian Tucholski, Magnus Haraldson Høie, Paolo Marcatili, Mathieu Dupré, Magalie Duchateau, Martial Rey, Christian Malosse, Sabine Metzger, Amelie Boquoi, Florian Platten, Stefan U. Egelhaaf, Julia Chamot-Rooke…
    Citation: BMC Biology 2023 21:21
  26. DNA mutations of diverse types provide the raw material required for phenotypic variation and evolution. In the case of crop species, previous research aimed to elucidate the changing patterns of repetitive se...

    Authors: Xiaoming Zheng, Limei Zhong, Hongbo Pang, Siyu Wen, Fei Li, Danjing Lou, Jinyue Ge, Weiya Fan, Tianyi Wang, Zhenyun Han, Weihua Qiao, Xiaowu Pan, Yebao Zhu, Jilin Wang, Cuifeng Tang, Xinhua Wang…
    Citation: BMC Biology 2023 21:20
  27. Skeletal muscle development is a multistep process whose understanding is central in a broad range of fields and applications, from the potential medical value to human society, to its economic value associate...

    Authors: Shufang Cai, Bin Hu, Xiaoyu Wang, Tongni Liu, Zhuhu Lin, Xian Tong, Rong Xu, Meilin Chen, Tianqi Duo, Qi Zhu, Ziyun Liang, Enru Li, Yaosheng Chen, Jianhao Li, Xiaohong Liu and Delin Mo
    Citation: BMC Biology 2023 21:19
  28. The loach (Misgurnus anguillicaudatus), the most widely distributed species of the family Cobitidae, displays a mud-dwelling behavior and intestinal air-breathing, inhabiting the muddy bottom of extensive freshwa...

    Authors: Bing Sun, Yuwei Huang, L. Filipe C. Castro, Su Yang, Songqian Huang, Wu Jin, He Zhou, Shigeho Ijiri, Yi Luo, Jian Gao and Xiaojuan Cao
    Citation: BMC Biology 2023 21:18
  29. The majority of genes in the human genome is present in two copies but the expression levels of both alleles is not equal. Allelic imbalance is an aspect of gene expression relevant not only in the context of ...

    Authors: Paweł Joachimiak, Adam Ciesiołka, Emilia Kozłowska, Paweł M. Świtoński, Grzegorz Figura, Agata Ciołak, Grażyna Adamek, Magdalena Surdyka, Żaneta Kalinowska-Pośka, Maciej Figiel, Nicholas S. Caron, Michael R. Hayden and Agnieszka Fiszer
    Citation: BMC Biology 2023 21:17
  30. Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of bone m...

    Authors: Gregory R. Gipson, Kristof Nolan, Chandramohan Kattamuri, Alan P. Kenny, Zachary Agricola, Nicole A. Edwards, Joseph Zinski, Magdalena Czepnik, Mary C. Mullins, Aaron M. Zorn and Thomas B. Thompson
    Citation: BMC Biology 2023 21:16
  31. Rhizoctonia solani is a polyphagous fungal pathogen that causes diseases in crops. The fungal strains are classified into anastomosis groups (AGs); however, genomic complexity, diversification into the AGs and th...

    Authors: Aleena Francis, Srayan Ghosh, Kriti Tyagi, V. Prakasam, Mamta Rani, Nagendra Pratap Singh, Amrita Pradhan, R. M. Sundaram, C. Priyanka, G. S. Laha, C. Kannan, M. S. Prasad, Debasis Chattopadhyay and Gopaljee Jha
    Citation: BMC Biology 2023 21:15
  32. Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasi...

    Authors: Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés and Véronique Pons
    Citation: BMC Biology 2023 21:14
  33. Folates are crucial for the biosynthesis of nucleotides and amino acids, essential for cell proliferation and development. Folate deficiency induces DNA damage, developmental defects, and tumorigenicity. The o...

    Authors: Michal Stark, May Levin, Igor Ulitsky and Yehuda G. Assaraf
    Citation: BMC Biology 2023 21:13
  34. Protein solubility is a precondition for efficient heterologous protein expression at the basis of most industrial applications and for functional interpretation in basic research. However, recurrent formation...

    Authors: Chao Wang and Quan Zou
    Citation: BMC Biology 2023 21:12
  35. Insects live in almost every habitat on earth. To adapt to their diverse environments, insects have developed a myriad of different strategies for reproduction reflected in diverse anatomical and behavioral fe...

    Authors: Heng Zhang, Feng Guang Goh, Lee Ching Ng, Chun Hong Chen and Yu Cai
    Citation: BMC Biology 2023 21:11
  36. A rapid, accurate method to identify and to age-grade mosquito populations would be a major advance in predicting the risk of pathogen transmission and evaluating the public health impact of vector control int...

    Authors: Iris Wagner, Linda Grigoraki, Peter Enevoldson, Michael Clarkson, Sam Jones, Jane L. Hurst, Robert J. Beynon and Hilary Ranson
    Citation: BMC Biology 2023 21:10
  37. Regulatory T cells (Treg) in diverse species include CD4+ and CD8+ T cells. In all species, CD8+ Treg have been only partially characterized and there is no rat model in which CD4+ and CD8+ FOXP3+ Treg are geneti...

    Authors: Séverine Ménoret, Laurent Tesson, Séverine Remy, Victor Gourain, Céline Sérazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Hélène Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau and Ignacio Anegon
    Citation: BMC Biology 2023 21:8
  38. Innate immunity is the first line of defense against pathogens. In animals, the Toll pathway, the Imd pathway, the complement system, and lectins are well-known mechanisms involved in innate immunity. Although...

    Authors: Andrea Orús-Alcalde, Aina Børve and Andreas Hejnol
    Citation: BMC Biology 2023 21:7
  39. Methods for the long-term in situ transduction of the unperturbed murine intestinal epithelium have not been developed in past research. Such a method could speed up functional studies and screens to identify ...

    Authors: George B. Garside, Madeline Sandoval, Slobodan Beronja and K. Lenhard Rudolph
    Citation: BMC Biology 2023 21:6
  40. Eusociality is widely considered to evolve through kin selection, where the reproductive success of an individual’s close relative is favored at the expense of its own. High genetic relatedness is thus conside...

    Authors: Samuel D. Robinson, Vanessa Schendel, Christina I. Schroeder, Sarah Moen, Alexander Mueller, Andrew A. Walker, Naomi McKinnon, G. Gregory Neely, Irina Vetter, Glenn F. King and Eivind A. B. Undheim
    Citation: BMC Biology 2023 21:5
  41. Camponotus floridanus ant colonies are comprised of a single reproductive queen and thousands of sterile female offspring that consist of two morphologically distinct castes: smaller minors and larger majors. Min...

    Authors: S. T. Ferguson, I. Bakis, N. D. Edwards and L. J. Zwiebel
    Citation: BMC Biology 2023 21:3
  42. The black cutworm, Agrotis ipsilon, is a serious global underground pest. Its distinct phenotypic traits, especially its polyphagy and ability to migrate long distances, contribute to its widening distribution an...

    Authors: Minghui Jin, Bo Liu, Weigang Zheng, Conghui Liu, Zhenxing Liu, Yuan He, Xiaokang Li, Chao Wu, Ping Wang, Kaiyu Liu, Shigang Wu, Hangwei Liu, Swapan Chakrabarty, Haibin Yuan, Kenneth Wilson, Kongming Wu…
    Citation: BMC Biology 2023 21:2
  43. Prolonged cellular activity may overload cell function, leading to high rates of protein synthesis and accumulation of misfolded or unassembled proteins, which cause endoplasmic reticulum (ER) stress and activ...

    Authors: Amina Aboufares El Alaoui, Edgar Buhl, Sabrina Galizia, James J. L. Hodge, Luisa de Vivo and Michele Bellesi
    Citation: BMC Biology 2023 21:1
  44. Laterality in relation to behavior and sensory systems is found commonly in a variety of animal taxa. Despite the advantages conferred by laterality (e.g., the startle response and complex motor activities), l...

    Authors: Vânia Filipa Lima Fernandes, Yannik Glaser, Motoko Iwashita and Masato Yoshizawa
    Citation: BMC Biology 2022 20:295
  45. SMYD3, a member of the SET and MYND domain-containing (SMYD) family, is a histone methyltransferase (HMT) and transcription factor that plays an important role in transcriptional regulation in human carcinogen...

    Authors: Yang Yang, Rongfang Qiu, Siyu Zhao, Lin Shen, Bufu Tang, Qiaoyou Weng, Ziwei Xu, Liyun Zheng, Weiqian Chen, Gaofeng Shu, Yajie Wang, Zhongwei Zhao, Minjiang Chen and Jiansong Ji
    Citation: BMC Biology 2022 20:294
  46. Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification by mutating the immunoglobulin loci. AID-driven an...

    Authors: Atefeh Ghorbani, S. Javad Khataeipour, Monica H. Solbakken, David N. G. Huebert, Minasadat Khoddami, Khalil Eslamloo, Cassandra Collins, Tiago Hori, Sissel Jentoft, Matthew L. Rise and Mani Larijani
    Citation: BMC Biology 2022 20:293
  47. Animals form complex symbiotic associations with their gut microbes, whose evolution is determined by an intricate network of host and environmental factors. In many insects, such as Drosophila melanogaster, the ...

    Authors: Elisa Maritan, Marialaura Gallo, Dagmar Srutkova, Anna Jelinkova, Oldrich Benada, Olga Kofronova, Nuno F. Silva-Soares, Tomas Hudcovic, Isaac Gifford, Jeffrey E. Barrick, Martin Schwarzer and Maria Elena Martino
    Citation: BMC Biology 2022 20:290
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