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  1. Women facing increased energetic demands in childhood commonly have altered adult ovarian activity and shorter reproductive lifespan, possibly comprising a strategy to optimize reproductive success. Here, we s...

    Authors: Ben Bar-Sadeh, Or E. Amichai, Lilach Pnueli, Khurshida Begum, Gregory Leeman, Richard D. Emes, Reinhard Stöger, Gillian R. Bentley and Philippa Melamed
    Citation: BMC Biology 2022 20:11
  2. The application of CRISPR/Cas9 technology in human induced pluripotent stem cells (hiPSC) holds tremendous potential for basic research and cell-based gene therapy. However, the fulfillment of these promises r...

    Authors: Joffrey Mianné, Amel Nasri, Chloé Nguyen Van, Chloé Bourguignon, Mathieu Fieldès, Engi Ahmed, Christine Duthoit, Nicolas Martin, Hugues Parrinello, Anaïs Louis, Alexandra Iché, Régis Gayon, Florine Samain, Lucille Lamouroux, Pascale Bouillé, Arnaud Bourdin…
    Citation: BMC Biology 2022 20:8
  3. The cytoskeleton is a key component of the system responsible for transmitting mechanical cues from the cellular environment to the nucleus, where they trigger downstream responses. This communication is parti...

    Authors: Juan José Romero, María Cecilia De Rossi, Camila Oses, Camila Vázquez Echegaray, Paula Verneri, Marcos Francia, Alejandra Guberman and Valeria Levi
    Citation: BMC Biology 2022 20:6
  4. Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determ...

    Authors: Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl and Gen Hua Yue
    Citation: BMC Biology 2022 20:5
  5. Group II introns are mobile genetic elements that can insert at specific target sequences, however, their origins are often challenging to reconstruct because of rapid sequence decay following invasion and spr...

    Authors: Dongseok Kim, JunMo Lee, Chung Hyun Cho, Eun Jeung Kim, Debashish Bhattacharya and Hwan Su Yoon
    Citation: BMC Biology 2022 20:2
  6. Across the Metazoa, similar genetic programs are found in the development of analogous, independently evolved, morphological features. The functional significance of this reuse and the underlying mechanisms of...

    Authors: Stephanie Neal, Kyle J. McCulloch, Francesca R. Napoli, Christina M. Daly, James H. Coleman and Kristen M. Koenig
    Citation: BMC Biology 2022 20:1
  7. The cervicovaginal microbiome (CVM) plays a significant role in women’s cervical health and disease. Microbial alterations at the species level and characteristic community state types (CST) have been associat...

    Authors: Karolina M. Andralojc, Mariano A. Molina, Mengjie Qiu, Bram Spruijtenburg, Menno Rasing, Bernard Pater, Martijn A. Huynen, Bas E. Dutilh, Thomas H. A. Ederveen, Duaa Elmelik, Albert G. Siebers, Diede Loopik, Ruud L. M. Bekkers, William P. J. Leenders and Willem J. G. Melchers
    Citation: BMC Biology 2021 19:267
  8. Rett syndrome (RTT) is a monogenic X-linked neurodevelopmental disorder characterized by loss-of-function mutations in the MECP2 gene, which lead to structural and functional changes in synapse communication, ...

    Authors: Clara Alice Musi, Anna Maria Castaldo, Anna Elisa Valsecchi, Sara Cimini, Noemi Morello, Riccardo Pizzo, Alessandra Renieri, Ilaria Meloni, Maurizio Bonati, Maurizio Giustetto and Tiziana Borsello
    Citation: BMC Biology 2021 19:256
  9. Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, pot...

    Authors: Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon and Andrew J. Murray
    Citation: BMC Biology 2021 19:265
  10. Ciliated protists are a widely distributed, morphologically diverse, and genetically heterogeneous group of unicellular organisms, usually known for containing two types of nuclei: a transcribed polyploid macr...

    Authors: Wenbing Chen, Changling Zuo, Chundi Wang, Tengteng Zhang, Liping Lyu, Yu Qiao, Fangqing Zhao and Miao Miao
    Citation: BMC Biology 2021 19:264
  11. Cells and organisms typically cannot survive in the absence of water. However, some animals including nematodes, tardigrades, rotifers, and some arthropods are able to survive near-complete desiccation. One cl...

    Authors: Jonathan D. Hibshman and Bob Goldstein
    Citation: BMC Biology 2021 19:263
  12. Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bac...

    Authors: Qipeng Cheng, Yanchu Cheung, Chenyu Liu, Qingjie Xiao, Bo Sun, Jiahai Zhou, Edward Wai Chi Chan, Rong Zhang and Sheng Chen
    Citation: BMC Biology 2021 19:262
  13. Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells. Distinct PP-InsPs species are characterized by the pre...

    Authors: Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari and Ajay Kumar Pandey
    Citation: BMC Biology 2021 19:261
  14. The integrity of microtubule filament networks is essential for the roles in diverse cellular functions, and disruption of its structure or dynamics has been explored as a therapeutic approach to tackle diseas...

    Authors: Ashley M. Rozario, Sam Duwé, Cade Elliott, Riley B. Hargreaves, Gregory W. Moseley, Peter Dedecker, Donna R. Whelan and Toby D. M. Bell
    Citation: BMC Biology 2021 19:260
  15. Hunter-gatherer lifestyles dominated the southern African landscape up to ~ 2000 years ago, when herding and farming groups started to arrive in the area. First, herding and livestock, likely of East African o...

    Authors: Mário Vicente, Imke Lankheet, Thembi Russell, Nina Hollfelder, Vinet Coetzee, Himla Soodyall, Michael De Jongh and Carina M. Schlebusch
    Citation: BMC Biology 2021 19:259
  16. Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans, Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG ...

    Authors: Stefanie Mühlhausen, Hans Dieter Schmitt, Uwe Plessmann, Peter Mienkus, Pia Sternisek, Thorsten Perl, Michael Weig, Henning Urlaub, Oliver Bader and Martin Kollmar
    Citation: BMC Biology 2021 19:258
  17. The evolutionary history of cell types provides insights into how morphological and functional complexity arose during animal evolution. Photoreceptor cell types are particularly broadly distributed throughout...

    Authors: Jonathan E. Valencia, Roberto Feuda, Dan O. Mellott, Robert D. Burke and Isabelle S. Peter
    Citation: BMC Biology 2021 19:257
  18. The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimi...

    Authors: Kate A. Rawlinson, Adam J. Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Avril Coghlan, Geetha Sankaranarayanan, Sarah K. Buddenborg, Carmen Diaz Soria, Catherine McCarthy, Nancy Holroyd, Mandy Sanders, Karl F. Hoffmann, David Wilcockson, Gabriel Rinaldi and Matthew Berriman
    Citation: BMC Biology 2021 19:255
  19. Functional genomic analyses rely on high-quality genome assemblies and annotations. Highly contiguous genome assemblies have become available for a variety of species, but accurate and complete annotation of g...

    Authors: Emily J. Shields, Masato Sorida, Lihong Sheng, Bogdan Sieriebriennikov, Long Ding and Roberto Bonasio
    Citation: BMC Biology 2021 19:254
  20. Snakes and primates have a multi-layered coevolutionary history as predators, prey, and competitors with each other. Previous work has explored the Snake Detection Theory (SDT), which focuses on the role of sn...

    Authors: Richard J. Harris, K. Anne-Isola Nekaris and Bryan G. Fry
    Citation: BMC Biology 2021 19:253
  21. Although electrical stimulation of the peripheral and central nervous systems has attracted much attention owing to its potential therapeutic effects on neuropsychiatric diseases, its non-cell-type-specific ac...

    Authors: Yi Cao, Suwan Pan, Mengying Yan, Chongyang Sun, Jianyu Huang, Cheng Zhong, Liping Wang and Lu Yi
    Citation: BMC Biology 2021 19:252
  22. The phylum Euglenozoa is a group of flagellated protists comprising the diplonemids, euglenids, symbiontids, and kinetoplastids. The diplonemids are highly abundant and speciose, and recent tools have rendered...

    Authors: Ingrid Škodová-Sveráková, Kristína Záhonová, Valéria Juricová, Maksym Danchenko, Martin Moos, Peter Baráth, Galina Prokopchuk, Anzhelika Butenko, Veronika Lukáčová, Lenka Kohútová, Barbora Bučková, Aleš Horák, Drahomíra Faktorová, Anton Horváth, Petr Šimek and Julius Lukeš
    Citation: BMC Biology 2021 19:251
  23. Diatoms usually dominate phytoplankton blooms in open oceans, exhibiting extremely high population densities. Although the iron uptake rate of diatoms largely determines the magnitude and longevity of diatom b...

    Authors: Xuehua Liu, Xiujun Xie, Shan Gao, Lepu Wang, Lu Zhou, Yao Liu, Qiang Hu, Wenhui Gu and Guangce Wang
    Citation: BMC Biology 2021 19:249
  24. Lipid species are accurately distributed in the eukaryotic cell so that organelle and plasma membranes have an adequate lipid composition to support numerous cellular functions. In the plasma membrane, a preci...

    Authors: Souade Ikhlef, Nicolas-Frédéric Lipp, Vanessa Delfosse, Nicolas Fuggetta, William Bourguet, Maud Magdeleine and Guillaume Drin
    Citation: BMC Biology 2021 19:248
  25. The main function of telomerase is at the telomeres but under adverse conditions telomerase can bind to internal regions causing deleterious effects as observed in cancer cells.

    Authors: Satyaprakash Pandey, Mona Hajikazemi, Theresa Zacheja, Stephanie Schalbetter, Matthew J. Neale, Jonathan Baxter, Victor Guryev, Andreas Hofmann, Dieter W. Heermann, Stefan A. Juranek and Katrin Paeschke
    Citation: BMC Biology 2021 19:247

    The Correction to this article has been published in BMC Biology 2022 20:29

  26. Cell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic a...

    Authors: Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon and Jacques Behmoaras
    Citation: BMC Biology 2021 19:246
  27. The Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and is essential for cell growth, proliferation, and differentiation. Rece...

    Authors: Yuanyuan Shi, Jian Chen, Wei-Jie Zeng, Miao Li, Wenxue Zhao, Xing-Ding Zhang and Jie Yao
    Citation: BMC Biology 2021 19:245
  28. Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set o...

    Authors: Anabella P. Trigila, Francisco Pisciottano and Lucía F. Franchini
    Citation: BMC Biology 2021 19:244
  29. Circulating miRNAs (c-miRNAs) are found in most, if not all, biological fluids and are becoming well-established non-invasive biomarkers of many human pathologies. However, their features in non-pathological c...

    Authors: Emilie Cardona, Cervin Guyomar, Thomas Desvignes, Jérôme Montfort, Samia Guendouz, John H. Postlethwait, Sandrine Skiba-Cassy and Julien Bobe
    Citation: BMC Biology 2021 19:235
  30. The radiation of ecdysozoans (moulting animals) during the Cambrian gave rise to panarthropods and various groups of worms including scalidophorans, which played an important role in the elaboration of early m...

    Authors: Deng Wang, Jean Vannier, Cédric Aria, Jie Sun and Jian Han
    Citation: BMC Biology 2021 19:243

    The Correction to this article has been published in BMC Biology 2022 20:30

  31. The rice weevil Sitophilus oryzae is one of the most important agricultural pests, causing extensive damage to cereal in fields and to stored grains. S. oryzae has an intracellular symbiotic relationship (endosym...

    Authors: Nicolas Parisot, Carlos Vargas-Chávez, Clément Goubert, Patrice Baa-Puyoulet, Séverine Balmand, Louis Beranger, Caroline Blanc, Aymeric Bonnamour, Matthieu Boulesteix, Nelly Burlet, Federica Calevro, Patrick Callaerts, Théo Chancy, Hubert Charles, Stefano Colella, André Da Silva Barbosa…
    Citation: BMC Biology 2021 19:241
  32. Oral microbiome dysbiosis is linked to overt inflammation of tooth-supporting tissues, leading to periodontitis, an oral condition that can cause tooth and bone loss. Microbiome dysbiosis has been described as...

    Authors: Ana Duran-Pinedo, Jose Solbiati, Flavia Teles, Ricardo Teles, Yanping Zang and Jorge Frias-Lopez
    Citation: BMC Biology 2021 19:240
  33. Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases,...

    Authors: Guiran Xiao, Mengran Zhao, Zhihua Liu, Fan Du and Bing Zhou
    Citation: BMC Biology 2021 19:236
  34. Shipworms are marine xylophagus bivalve molluscs, which can live on a diet solely of wood due to their ability to produce plant cell wall-degrading enzymes. Bacterial carbohydrate-active enzymes (CAZymes), syn...

    Authors: Giovanna Pesante, Federico Sabbadin, Luisa Elias, Clare Steele-King, J. Reuben Shipway, Adam A. Dowle, Yi Li, Marta Busse-Wicher, Paul Dupree, Katrin Besser, Simon M. Cragg, Neil C. Bruce and Simon J. McQueen-Mason
    Citation: BMC Biology 2021 19:233
  35. Flowering plants (angiosperms) are dominant components of global terrestrial ecosystems, but phylogenetic relationships at the familial level and above remain only partially resolved, greatly impeding our full...

    Authors: Hong-Tao Li, Yang Luo, Lu Gan, Peng-Fei Ma, Lian-Ming Gao, Jun-Bo Yang, Jie Cai, Matthew A. Gitzendanner, Peter W. Fritsch, Ting Zhang, Jian-Jun Jin, Chun-Xia Zeng, Hong Wang, Wen-Bin Yu, Rong Zhang, Michelle van der Bank…
    Citation: BMC Biology 2021 19:232
  36. The detection of environmental cues and signals via the sensory system directs behavioral choices in diverse organisms. Insect larvae rely on input from the chemosensory system, mainly olfaction, for locating ...

    Authors: Santosh V. Revadi, Vito Antonio Giannuzzi, Valeria Rossi, Gert Martin Hunger, Lucie Conchou, Gabriele Rondoni, Eric Conti, Peter Anderson, William B. Walker, Emmanuelle Jacquin-Joly, Fotini Koutroumpa and Paul G. Becher
    Citation: BMC Biology 2021 19:231
  37. Blowflies are ubiquitous insects, often shiny and metallic, and the larvae of many species provide important ecosystem services (e.g., recycling carrion) and are used in forensics and debridement therapy. Yet,...

    Authors: Liping Yan, Thomas Pape, Karen Meusemann, Sujatha Narayanan Kutty, Rudolf Meier, Keith M. Bayless and Dong Zhang
    Citation: BMC Biology 2021 19:230
  38. Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins. These proteins are generally considered to be binary co...

    Authors: Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér and Jian Zhao
    Citation: BMC Biology 2021 19:229
  39. Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane.

    Authors: Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon…
    Citation: BMC Biology 2021 19:228
  40. Female reproductive behaviors and physiology change profoundly after mating. The control of pregnancy-associated changes in physiology and behaviors are largely hard-wired into the brain to guarantee reproduct...

    Authors: Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta and Matthias Soller
    Citation: BMC Biology 2021 19:226
  41. Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that transduces extracellular signals in virtually all eukaryotic cells. The soluble Beggiatoa photoactivatable adenylyl cyclase (bPAC) rapid...

    Authors: Shang Yang, Oana M. Constantin, Divya Sachidanandan, Hannes Hofmann, Tobias C. Kunz, Vera Kozjak-Pavlovic, Thomas G. Oertner, Georg Nagel, Robert J. Kittel, Christine E. Gee and Shiqiang Gao
    Citation: BMC Biology 2021 19:227