López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194–217.
Article
PubMed
PubMed Central
CAS
Google Scholar
Fontana L, Partridge L, Longo VD. Dietary restriction, growth factors and aging: from yeast to humans. Science. 2010;328:321–6.
Kaeberlein M. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005;310:1193–6.
Article
CAS
PubMed
Google Scholar
Wei M, Kim SK, Fabrizio P, Hu J, Ge H, Cheng C, et al. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. Plos Genet. 2008;4:e13–e11.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zuin A, Carmona Mercè, Morales-Ivorra I, Gabrielli N, Vivancos AP, Ayté J, et al. Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. Embo J. 2010;29:981–91.
Alvers AL, Wood MS, Hu D, Kaywell AC Jr, WAD, Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy. 2014;5:847–9.
Article
Google Scholar
Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012;16:18–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kaeberlein M. Lessons on longevity from budding yeast. Nature. 2010;464:513–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lippuner AD, Julou T, Barral Y. Budding yeast as a model organism to study the effects of age. Fems Microbiol Rev. 2014;38:300–25.
Article
CAS
Google Scholar
Zuin A, Gabrielli N, Calvo IA, García-Santamarina S, Hoe K-L, Kim DU, et al. Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS ONE. 2008;3: e2842.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mutoh N, Kitajima S. Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having Cu and Zn as cofactors and its enhancement by Sir2 deficiency. Biosci Biotechnology Biochem. 2007;71:2841–4.
Article
CAS
Google Scholar
Voos W, Jaworek W, Wilkening A, Bruderek M. Protein quality control at the mitochondrion. Essays Biochem. 2016;60:213–25.
Article
PubMed
Google Scholar
Dunn CD, Walter P, Tamura Y, Sesaki H, Jensen RE. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol Biol Cell. 2008;19:5387–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hughes AL, Gottschling DE. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature. 2013;492:261–5.
Article
CAS
Google Scholar
Fehrmann S, Paoletti C, Goulev Y, Ungureanu A, Aguilaniu H, Charvin G. Aging yeast cells undergo a sharp entry into senescence unrelated to the loss of mitochondrial membrane potential. Cell Rep. 2013;5:1589–99.
Article
CAS
PubMed
Google Scholar
Stephan J, Franke J, Ehrenhofer-Murray AE. Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension. Aging Cell. 2013;12:574–83.
Article
CAS
PubMed
Google Scholar
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz HD. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol. 2007;9:99–105.
Article
CAS
PubMed
Google Scholar
Scheckhuber CQ, Wanger RA, Mignat CA, Osiewacz HD. Unopposed mitochondrial fission leads to severe lifespan shortening. Cell Cycle. 2011;10:3105–10.
Article
CAS
PubMed
Google Scholar
Bernhardt D, Müller M, Reichert AS, Osiewacz HD. Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep-uk. 2015;5:503–9.
Google Scholar
Wang K, Klionsky DJ. Mitochondria removal by autophagy. Autophagy. 2014;7:297–300.
Article
CAS
Google Scholar
Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell. 2009;17:98–109.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao D, Liu X-M, Yu Z-Q, Sun L-L, Xiong X, Dong M-Q, et al. Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast. J Cell Sci. 2016;129:4289–304.
CAS
PubMed
Google Scholar
Fukuda T, Ebi Y, Saigusa T, Furukawa K, Yamashita S, Inoue K, et al. Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast. Elife. 2020;9:3206–29.
Article
Google Scholar
Ocampo A, Barrientos A. Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry. Mech Ageing Dev. 2011;132:315–23.
Article
CAS
PubMed
Google Scholar
Roux AE, Quissac A, Chartrand P, Ferbeyre G, Rokeach LA. Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell. 2006;5:345–57.
Article
CAS
PubMed
Google Scholar
Harbauer AB, Zahedi RP, Sickmann A, Pfanner N, Meisinger C. The protein import machinery of mitochondria-a regulatory hub in metabolism, stress, and disease. Cell Metab. 2014;19:357–72.
Article
CAS
PubMed
Google Scholar
Pak VV, Ezeriņa D, Lyublinskaya OG, Pedre B, Tyurin-Kuzmin PA, Mishina NM, et al. Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function. Cell Metab. 2020;31:642-653.e6.
Article
CAS
PubMed
PubMed Central
Google Scholar
de Cubas L, Pak VV, Belousov VV, Ayté J, Hidalgo E. The mitochondria-to-cytosol H2O2 gradient is caused by peroxiredoxin-dependent cytosolic scavenging. Antioxidants. 2021;10:731.
Article
PubMed
PubMed Central
CAS
Google Scholar
van der Bliek AM, Shen Q, Kawajiri S. Mechanisms of mitochondrial fission and fusion. Csh Perspect Biol. 2013;5:a011072–a011072.
Google Scholar
Rabl R, Soubannier V, Scholz R, Vogel F, Mendl N, Vasiljev-Neumeyer A, et al. Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biology. 2009;185:1047–63.
Article
CAS
Google Scholar
Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, et al. Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nat Commun. 2017;8:448.
Article
PubMed
PubMed Central
CAS
Google Scholar
Valente AJ, Maddalena LA, Robb EL, Moradi F, Stuart JA. A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture. Acta Histochem. 2017;119:315–26.
Article
CAS
PubMed
Google Scholar
Palikaras K, Lionaki E, Tavernarakis N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature. 2015;521:525–8.
Article
CAS
PubMed
Google Scholar
Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, et al. Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr Biol. 2015;25:1810–22.
Article
CAS
PubMed
Google Scholar
Richard VR, Leonov A, Beach A, Burstein MT, Koupaki O, Gomez-Perez A, et al. Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging. 2013;5:234–69.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ocampo A, Liu J, Schroeder EA, Shadel GS, Barrientos A. Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab. 2012;16:55–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kwon Y-Y, Choi K-M, Cho C, Lee C-K. Mitochondrial efficiency-dependent viability of Saccharomyces cerevisiae mutants carrying individual electron transport chain component deletions. Mol Cells. 2015;38:1054–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hacioglu E, Demir AB, Koc A. Identification of respiratory chain gene mutations that shorten replicative life span in yeast. Exp Gerontol. 2012;47:149–53.
Article
CAS
PubMed
Google Scholar
Li W, Sun L, Liang Q, Wang J, Mo W, Zhou B. Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell. 2006;17:1802–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee S-J, Hwang AB, Kenyon C. Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol. 2010;20:2131–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Labbadia J, Brielmann RM, Neto MF, Lin Y-F, Haynes CM, Morimoto RI. Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging. Cell Rep. 2017;21:1481–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tavallaie M, Voshtani R, Deng X, Qiao Y, Jiang F, Collman JP, et al. Moderation of mitochondrial respiration mitigates metabolic syndrome of aging. Proc Natl Acad Sci. 2020;117:9840–50.
Wagner I, Arlt H, van Dyck L, Langer T, Neupert W. Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. Embo J. 1994;13:5135–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Savel’ev AS, Novikova LA, Kovaleva IE, Luzikov VN, Neupert W, Langer T. ATP-dependent proteolysis in mitochondria. m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system. J Biol Chem. 1998;273:20596–602.
Bota DA, Davies KJA. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002;4:674–80.
Article
CAS
PubMed
Google Scholar
Erjavec N, Bayot A, Gareil M, Camougrand N, Nystrom T, Friguet B, et al. Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome. Free Radical Bio Med. 2013;56:9–16.
Article
CAS
Google Scholar
Luce K, Osiewacz HD. Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol. 2009;11:852–8.
Article
CAS
PubMed
Google Scholar
Wang Y, Yan J, Zhang Q, Ma X, Zhang J, Su M, et al. The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator. Nucleic Acids Res. 2017;45:3323–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matsushima Y, Goto Y, Kaguni LS. Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci. 2010;107:18410–5.
Nolden M, Ehses S, Koppen M, Bernacchia A, Rugarli EI, Langer T. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Cell. 2005;123:277–89.
Article
CAS
PubMed
Google Scholar
Guha S, López-Maury L, Shaw M, Bähler J, Norbury CJ, Agashe VR. Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast. J Mol Biol. 2011;408:222–37.
Article
CAS
PubMed
Google Scholar
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6:280–93.
Article
CAS
PubMed
Google Scholar
Roux AE, Dutcher SK, Leroux A, Alaamery MA, Hoffman CS, Chartrand P, et al. Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. Plos Genet. 2009;5:e1000408–17.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kaya A, Phua CZJ, Lee M, Wang L, Tyshkovskiy A, Ma S, et al. Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast. Elife. 2021;10: e64860.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin Y, Lu J, Zhang J, Walter W, Dang W, Wan J, et al. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009;136:1073–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, et al. Sir2 blocks extreme life-span extension. Cell. 2005;123:655–67.
Article
CAS
PubMed
Google Scholar
Casatta N, Porro A, Orlandi I, Brambilla L, Vai M. Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors. Biochimica Et Biophysica Acta Bba - Mol Cell Res. 2013;1833:593–601.
Article
CAS
Google Scholar
Orlandi I, Coppola DP, Strippoli M, Ronzulli R, Vai M. Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging. Mech Ageing Dev. 2017;161:277–87.
Article
CAS
PubMed
Google Scholar
Yuan Y, Cruzat VF, Newsholme P, Cheng J, Chen Y, Lu Y. Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis. Mech Ageing Dev. 2016;155:10–21.
Article
CAS
PubMed
Google Scholar
Pereira C, Costa V, Martins LM, Saraiva L. A yeast model of the Parkinson’s disease-associated protein Parkin. Exp Cell Res. 2015;333:73–9.
Article
CAS
PubMed
Google Scholar
Wang K, Jin M, Liu X, Klionsky DJ. Proteolytic processing of Atg32 by the mitochondrial i-AAA protease Yme1 regulates mitophagy. Autophagy. 2014;9:1828–36.
Article
CAS
Google Scholar
Alfa C, Fantes P, Hyams J, McLeod M, Warbrick E. Experiments with Fission Yeast: A Laboratory Course Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory; 1993.
Murakami C, Kaeberlein M. Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp Jove. 2009;27: e1156.
Google Scholar
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.
Article
PubMed
PubMed Central
CAS
Google Scholar
Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676–82.
Article
CAS
PubMed
Google Scholar
Vivancos AP, Castillo EA, Biteau B, Nicot C, Ayté J, Toledano MB, et al. A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway. Proc Natl Acad Sci. 2005;102:8875–80.
Jara M, Fox T, Vivancos AP, Calvo IA, Moldón A, Sansó M, et al. The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Mol Biol Cell. 2007;18:2288–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chiron S, Gaisne M, Guillou E, Belenguer P, Clark-Walker GD, Bonnefoy N. Studying mitochondria in an attractive model: Schizosaccharomyces pombe. Methods Mol Biol. 2007;372:91–105.