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  1. Lactoferrin is an active protein in breast milk that plays an important role in the growth and development of infants and is implicated as a neuroprotective agent. The incidence of depression is currently incr...

    Authors: Wenli Wang, Zhimei Cheng, Xiong Wang, Qin An, Kunlun Huang, Yunping Dai, Qingyong Meng and Yali Zhang
    Citation: BMC Biology 2023 21:242
  2. The Sino-Himalayan flora harbors highly diverse high-elevation biotas, but our understanding of its evolutionary history in temporal and spatial dimensions is limited. In this study, we integrated a dated phyl...

    Authors: Yun Liu, Yang-Jun Lai, Jian-Fei Ye, Hai-Hua Hu, Dan-Xiao Peng, Li-Min Lu, Hang Sun and Zhi-Duan Chen
    Citation: BMC Biology 2023 21:239
  3. The recruitment of effector cells is one of the novel functions described for extracellular vesicles (EVs) that needs further study. For instance, cell recruitment by mesenchymal stromal cell derived-EVs (MSC-...

    Authors: Marta Clos-Sansalvador, Marta Monguió-Tortajada, Ferran Grau-Leal, Vicenç Ruiz de Porras, Sergio G. Garcia, Marta Sanroque-Muñoz, Miriam Font-Morón, Marcella Franquesa and Francesc E. Borràs
    Citation: BMC Biology 2023 21:236
  4. Severe peripheral nerve injury (PNI) often leads to significant movement disorders and intractable pain. Therefore, promoting nerve regeneration while avoiding neuropathic pain is crucial for the clinical trea...

    Authors: Qi Chen, Xi-Yin Zhang, Yu-Pu Wang, Yun-Jie Fu, Feng Cao, Yi-Nuo Xu, Jin-Ge Kong, Na-Xi Tian, Yu Xu and Yun Wang
    Citation: BMC Biology 2023 21:235
  5. The reuse of dredged sediments in ports and lagoons is a big issue as it should not affect the quality and the equilibrium of ecosystems. In the lagoon of Venice, sediment management is of crucial importance a...

    Authors: Ilaria Bernardini, Andrea Quagliariello, Luca Peruzza, Maria Elena Martino, Giulia Dalla Rovere, Silvia Iori, Davide Asnicar, Maria Ciscato, Jacopo Fabrello, Fabiana Corami, Martina Cecchetto, Elisa Giubilato, Claudio Carrer, Cinzia Bettiol, Elena Semenzin, Antonio Marcomini…
    Citation: BMC Biology 2023 21:234
  6. The population structure of crop pathogens such as Puccinia striiformis f. sp. tritici (Pst), the cause of wheat stripe rust, is of interest to researchers looking to understand these pathogens on a molecular lev...

    Authors: Samuel Holden, Guus Bakkeren, John Hubensky, Ramandeep Bamrah, Mehrdad Abbasi, Dinah Qutob, Mei-Lan de Graaf, Sang Hu Kim, Hadley R. Kutcher, Brent D. McCallum, Harpinder S. Randhawa, Muhammad Iqbal, Keith Uloth, Rishi R. Burlakoti and Gurcharn S. Brar
    Citation: BMC Biology 2023 21:233
  7. RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited.

    Authors: Wen-Long Lei, Zongchang Du, Tie-Gang Meng, Ruibao Su, Yuan-Yuan Li, Wenbo Liu, Si-Min Sun, Meng-Yu Liu, Yi Hou, Chun-Hui Zhang, Yaoting Gui, Heide Schatten, Zhiming Han, Chenli Liu, Fei Sun, Zhen-Bo Wang…
    Citation: BMC Biology 2023 21:231
  8. Venoms, which have evolved numerous times in animals, are ideal models of convergent trait evolution. However, detailed genomic studies of toxin-encoding genes exist for only a few animal groups. The hyper-div...

    Authors: Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Günter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre…
    Citation: BMC Biology 2023 21:229
  9. The flatworm planarian, Schmidtea mediterranea, has a large population of adult stem cells (ASCs) that replace any cell type during tissue turnover or regeneration. How planarian ASCs (called neoblasts) manage se...

    Authors: Mallory Wiggans, Shu Jun Zhu, Alyssa M. Molinaro and Bret J. Pearson
    Citation: BMC Biology 2023 21:227
  10. Gene knockout and knock-in have been widely performed in large farm animals based on genome editing systems. However, many types of precise gene editing, including targeted deletion, gene tagging, and large ge...

    Authors: Ming Wang, Fangrong Ding, Haiping Wang, Ling Li, Yunping Dai, ZhaoLin Sun and Ning Li
    Citation: BMC Biology 2023 21:226
  11. Current solutions for the analysis of Western Blot images lack either transparency and reproducibility or can be tedious to use if one has to ensure the reproducibility of the analysis.

    Authors: Jaak Kütt, Georg Margus, Lauri Kask, Triinu Rätsepso, Kärol Soodla, Romain Bernasconi, Rikke Birkedal, Priit Järv, Martin Laasmaa and Marko Vendelin
    Citation: BMC Biology 2023 21:225
  12. Single-cell RNA-sequencing (scRNA-seq) has become a widely used tool for both basic and translational biomedical research. In scRNA-seq data analysis, cell type annotation is an essential but challenging step....

    Authors: Lu Yang, Yan Er Ng, Haipeng Sun, Ying Li, Lucas C. S. Chini, Nathan K. LeBrasseur, Jun Chen and Xu Zhang
    Citation: BMC Biology 2023 21:223
  13. Energy homeostasis is essential for the adaptation of animals to their environment and some wild animals keep low metabolism adaptive to their low-nutrient dietary supply. Giant panda is such a typical low-met...

    Authors: Shangchen Yang, Tianming Lan, Rongping Wei, Ling Zhang, Lin Lin, Hanyu Du, Yunting Huang, Guiquan Zhang, Shan Huang, Minhui Shi, Chengdong Wang, Qing Wang, Rengui Li, Lei Han, Dan Tang, Haimeng Li…
    Citation: BMC Biology 2023 21:222
  14. Through alternative splicing, most human genes produce multiple isoforms in a cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing is essential for development, diseases...

    Authors: Søren Helweg Dam, Lars Rønn Olsen and Kristoffer Vitting-Seerup
    Citation: BMC Biology 2023 21:220
  15. Social affinity and collective behavior are nearly ubiquitous in the animal kingdom, but many lineages feature evolutionarily asocial species. These solitary species may have evolved to conserve energy in food...

    Authors: Motoko Iwashita, Amity Tran, Marianne Garcia, Jia Cashon, Devanne Burbano, Vanessa Salgado, Malia Hasegawa, Rhoada Balmilero-Unciano, Kaylah Politan, Miki Wong, Ryan W. Y. Lee and Masato Yoshizawa
    Citation: BMC Biology 2023 21:219
  16. Group 2 innate lymphoid cells (ILC2s) are critical sources of type 2 cytokines and represent one of the major tissue-resident lymphoid cells in the mouse lung. However, the molecular mechanisms underlying ILC2...

    Authors: Shasha Xu, Yu Zhang, Xingjie Liu, Huisheng Liu, Xinya Zou, Linlin Zhang, Jing Wang, Zhiwei Zhang, Xiang Xu, Mingxia Li, Kairui Li, Shuyue Shi, Ying Zhang, Zhichao Miao, Jie Zha and Yong Yu
    Citation: BMC Biology 2023 21:218
  17. In the speciation continuum, the strength of reproductive isolation varies, and species boundaries are blurred by gene flow. Interbreeding among giraffe (Giraffa spp.) in captivity is known, and anecdotal reports...

    Authors: Raphael T. F. Coimbra, Sven Winter, Arthur Muneza, Stephanie Fennessy, Moses Otiende, Domnic Mijele, Symon Masiaine, Jenna Stacy-Dawes, Julian Fennessy and Axel Janke
    Citation: BMC Biology 2023 21:215
  18. Up to 40% of the world population live in areas where mosquitoes capable of transmitting the dengue virus, including Aedes aegypti, coexist with humans. Understanding how mosquito egg development and oviposition ...

    Authors: Jun Isoe, Carter J. Simington, Max E. Oscherwitz, Alyssa J. Peterson, Alberto A. Rascón Jr., Brooke B. Massani, Roger L. Miesfeld and Michael A. Riehle
    Citation: BMC Biology 2023 21:214
  19. Anthocyanin is a class of important secondary metabolites that determines colorful petals in chrysanthemum, a famous cut flower. ‘Arctic Queen’ is a white chrysanthemum cultivar that does not accumulate anthoc...

    Authors: Yuxi Wang, Yiguang Wang, Li-Jie Zhou, Jialin Peng, Chuwen Chen, Shenhui Liu, Aiping Song, Jiafu Jiang, Sumei Chen and Fadi Chen
    Citation: BMC Biology 2023 21:211
  20. Phasmatodea (stick and leaf insects) play a central role on the debate regarding wing reduction and loss, and its wings are putative reacquisition from secondarily wingless ancestors based solely on extant spe...

    Authors: Hongru Yang, Michael S. Engel, Chungkun Shih, Fan Song, Yisheng Zhao, Dong Ren and Taiping Gao
    Citation: BMC Biology 2023 21:210
  21. Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can y...

    Authors: Jinren Yu, Hong Zhao, Yanting Niu, Yichen You, Russell L. Barrett, Rindra Manasoa Ranaivoson, Romer Narindra Rabarijaona, Gaurav Parmar, Langxing Yuan, Xiaofeng Jin, Pan Li, Jianhua Li, Jun Wen, Zhiduan Chen and Limin Lu
    Citation: BMC Biology 2023 21:209
  22. Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood. Little ...

    Authors: Min-Sheng Peng, Yan-Hu Liu, Quan-Kuan Shen, Xiao-Hua Zhang, Jiajia Dong, Jin-Xiu Li, Hui Zhao, Hui Zhang, Xiaoming Zhang, Yaoxi He, Hong Shi, Chaoying Cui, Ouzhuluobu, Tian-Yi Wu, Shi-Ming Liu, Gonggalanzi…
    Citation: BMC Biology 2023 21:208
  23. The maternal microbiota modulates fetal development, but the mechanisms of these earliest host-microbe interactions are unclear. To investigate the developmental impacts of maternal microbial metabolites, we c...

    Authors: Aleksi Husso, Tiina Pessa-Morikawa, Ville Mikael Koistinen, Olli Kärkkäinen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva and Mikael Niku
    Citation: BMC Biology 2023 21:207
  24. Whereas the translocation of proteins across the cell membrane has been thoroughly investigated, it is still unclear how proteins cross the cell wall in Gram-positive bacteria, which are widely used for indust...

    Authors: Manuel Strach, Felicitas Koch, Svenja Fiedler, Klaus Liebeton and Peter L. Graumann
    Citation: BMC Biology 2023 21:206
  25. After the eradication of smallpox in China in 1979, vaccination with the vaccinia virus (VACV) Tiantan strain for the general population was stopped in 1980. As the monkeypox virus (MPXV) is rapidly spreading ...

    Authors: Anqi Xia, Xiaojie Wang, Jiaying He, Wei Wu, Weiyu Jiang, Song Xue, Qianqian Zhang, Yidan Gao, Yuru Han, Yaming Li, Xiaofang Peng, Minxiang Xie, Christian T. Mayer, Jie Liu, Chen Hua, Yiou Sha…
    Citation: BMC Biology 2023 21:205
  26. Molluscan shell, composed of a diverse range of architectures and microstructures, is a classic model system to study the relationships between molecular evolution and biomineralized structure formation. The s...

    Authors: Yitian Bai, Shikai Liu, Yiming Hu, Hong Yu, Lingfeng Kong, Chengxun Xu and Qi Li
    Citation: BMC Biology 2023 21:204
  27. Homology-based recombination (HR) is the cornerstone of genetic mapping. However, a lack of sufficient sequence homology or the presence of a genomic rearrangement prevents HR through crossing, which inhibits ...

    Authors: Dongying Xie, Bida Gu, Yiqing Liu, Pohao Ye, Yiming Ma, Tongshu Wen, Xiaoyuan Song and Zhongying Zhao
    Citation: BMC Biology 2023 21:203
  28. Brassica napus is an important oilseed crop providing high-quality vegetable oils for human consumption and non-food applications. However, the regulation between embryo and seed coat for the synthesis of oil and...

    Authors: Liangqian Yu, Dongxu Liu, Feifan Yin, Pugang Yu, Shaoping Lu, Yuting Zhang, Hu Zhao, Chaofu Lu, Xuan Yao, Cheng Dai, Qing-Yong Yang and Liang Guo
    Citation: BMC Biology 2023 21:202
  29. Lepidoptera (butterflies and moths) is one of the most geographically widespread insect orders in the world, and its species play important and diverse ecological and applied roles. Climate change is one of th...

    Authors: Ivy H. T. Lee, Wenyan Nong, Wai Lok So, Chris K. H. Cheung, Yichun Xie, Toby Baril, Ho Yin Yip, Thomas Swale, Simon K. F. Chan, Yingying Wei, Nathan Lo, Alexander Hayward, Ting Fung Chan, Hon-ming Lam and Jerome H. L. Hui
    Citation: BMC Biology 2023 21:200
  30. High-throughput sequencing measurements of the vaginal microbiome have yielded intriguing potential relationships between the vaginal microbiome and preterm birth (PTB; live birth prior to 37 weeks of gestatio...

    Authors: Caizhi Huang, Craig Gin, Jennifer Fettweis, Betsy Foxman, Bizu Gelaye, David A. MacIntyre, Akila Subramaniam, William Fraser, Negar Tabatabaei and Benjamin Callahan
    Citation: BMC Biology 2023 21:199
  31. As an extension of electron tomography (ET), serial section electron tomography (serial section ET) aims to align the tomographic images of multiple thick tissue sections together, to break through the volume ...

    Authors: Sheng Chang, Linlin Li, Bei Hong, Jing Liu, Yuxuan Xu, Keliang Pang, Lina Zhang, Hua Han and Xi Chen
    Citation: BMC Biology 2023 21:198
  32. The maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate regulations of the individual miRNA maturation are largely unknown. Retinoi...

    Authors: Xiaohong Ye, Yun Yang, Jiayue Yao, Mo Wang, Yixin Liu, Guobin Xie, Zhiping Zeng, Xiao-kun Zhang and Hu Zhou
    Citation: BMC Biology 2023 21:197
  33. The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect ...

    Authors: Xuefei Chen, Wenhua Huang, Jingbo Zhang, Yanjun Li, Zheng Xing, Lanlan Guo, Hongfeng Jiang and Jing Zhang
    Citation: BMC Biology 2023 21:196
  34. Adelphocoris suturalis (Hemiptera: Miridae) is a notorious agricultural pest, which causes serious economic losses to a diverse range of agricultural crops around the world. The poor understanding of its genomic ...

    Authors: Zhongping Xu, Guanying Wang, Jing Luo, Mingju Zhu, Lisong Hu, Sijia Liang, Bo Li, Xingxing Huang, Ying Wang, Guangyu Zhang, Can Zhang, Yi Zhou, Daojun Yuan, Taiyu Chen, Lizhen Chen, Weihua Ma…
    Citation: BMC Biology 2023 21:195
  35. Worldwide invasion and expansion of Aedes albopictus, an important vector of dengue, chikungunya, and Zika viruses, has become a serious concern in global public health. Chemical insecticides are the primary mean...

    Authors: Yijia Guo, Ke Hu, Jingni Zhou, Zhensheng Xie, Yijie Zhao, Siyu Zhao, Jinbao Gu, Xiaohong Zhou, Guiyun Yan, Anthony A. James and Xiao-Guang Chen
    Citation: BMC Biology 2023 21:194
  36. Prefoldin is an evolutionarily conserved co-chaperone of the tailless complex polypeptide 1 ring complex (TRiC)/chaperonin containing tailless complex 1 (CCT). The prefoldin complex consists of six subunits th...

    Authors: Ismail Tahmaz, Somayeh Shahmoradi Ghahe, Monika Stasiak, Kamila P. Liput, Katarzyna Jonak and Ulrike Topf
    Citation: BMC Biology 2023 21:193
  37. Lauraceae is well known for its significant phylogenetic position as well as important economic and ornamental value; however, most evergreen species in Lauraceae are restricted to tropical regions. In contras...

    Authors: Danqing Li, Han-Yang Lin, Xiuyun Wang, Bo Bi, Yuan Gao, Lingmei Shao, Runlong Zhang, Yuwei Liang, Yiping Xia, Yun-Peng Zhao, Xiaofan Zhou and Liangsheng Zhang
    Citation: BMC Biology 2023 21:192
  38. Trypanosomatids are parasitic flagellates well known because of some representatives infecting humans, domestic animals, and cultural plants. Many trypanosomatid species bear RNA viruses, which, in the case of...

    Authors: Diego H. Macedo, Danyil Grybchuk, Jana Režnarová, Jan Votýpka, Donnamae Klocek, Tatiana Yurchenko, Jan Ševčík, Alice Magri, Michaela Urda Dolinská, Kristína Záhonová, Julius Lukeš, Elena Servienė, Alexandra Jászayová, Saulius Serva, Marina N. Malysheva, Alexander O. Frolov…
    Citation: BMC Biology 2023 21:191
  39. Labeling efficiency is a crucial parameter in fluorescence applications, especially when studying biomolecular interactions. Current approaches for estimating the yield of fluorescent labeling have critical dr...

    Authors: Chiara Schirripa Spagnolo, Aldo Moscardini, Rosy Amodeo, Fabio Beltram and Stefano Luin
    Citation: BMC Biology 2023 21:190
  40. Researchers performing high-quality systematic reviews search across multiple databases to identify relevant evidence. However, the same publication is often retrieved from several databases. Identifying and r...

    Authors: Kaitlyn Hair, Zsanett Bahor, Malcolm Macleod, Jing Liao and Emily S. Sena
    Citation: BMC Biology 2023 21:189
  41. Intrinsically disordered regions (IDRs) are widely distributed in proteins and related to many important biological functions. Accurately identifying IDRs is of great significance for protein structure and fun...

    Authors: Yi-Jun Tang, Ke Yan, Xingyi Zhang, Ye Tian and Bin Liu
    Citation: BMC Biology 2023 21:188
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