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  1. In contrast to mammals, the zebrafish has the remarkable capacity to regenerate its pancreatic beta cells very efficiently. Understanding the mechanisms of regeneration in the zebrafish and the differences wit...

    Authors: Aurélie P. Ghaye, David Bergemann, Estefania Tarifeño-Saldivia, Lydie C. Flasse, Virginie Von Berg, Bernard Peers, Marianne L. Voz and Isabelle Manfroid
    Citation: BMC Biology 2015 13:70
  2. The opportunistic pathogen Candida glabrata is a member of the Saccharomycetaceae yeasts. Like its close relative Saccharomyces cerevisiae, it underwent a whole-genome duplication followed by an extensive loss of...

    Authors: Stéphane Descorps-Declère, Cyril Saguez, Axel Cournac, Martial Marbouty, Thomas Rolland, Laurence Ma, Christiane Bouchier, Ivan Moszer, Bernard Dujon, Romain Koszul and Guy-Franck Richard
    Citation: BMC Biology 2015 13:69
  3. Virus B is a newly emerged viral strain for which there is no current treatment. Drug A was identified as a potential treatment for infection with virus B. In this pre-clinical phase of drug testing, the effec...

    Authors: Emma Saxon
    Citation: BMC Biology 2015 13:68
  4. Cajal’s careful observations of the anatomy of the nervous system led him to some lesser-known predictions about the function of glia as mediators of sleep. Reporting over 120 years later in BMC Biology, Bellesi ...

    Authors: Matthew C F Tso and Erik D. Herzog
    Citation: BMC Biology 2015 13:67
  5. For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-ori...

    Authors: Yasushi Saka, Claudiu V. Giuraniuc and Hiroyuki Ohkura
    Citation: BMC Biology 2015 13:65
  6. Tim Hunt took an undergraduate degree in Natural Sciences at Cambridge in 1964, and his PhD and subsequent work focussed on the control of protein synthesis until 1982, when his adventitious discovery of the c...

    Authors: Tim Hunt
    Citation: BMC Biology 2015 13:64
  7. Insulators play a central role in gene regulation, chromosomal architecture and genome function in higher eukaryotes. To learn more about how insulators carry out their diverse functions, we have begun an anal...

    Authors: Artem Bonchuk, Oksana Maksimenko, Olga Kyrchanova, Tatyana Ivlieva, Vladic Mogila, Girish Deshpande, Daniel Wolle, Paul Schedl and Pavel Georgiev
    Citation: BMC Biology 2015 13:63
  8. Shear stress in arteries, which is a measure of the force exerted by blood flow on the arterial wall, is associated with the location of lipid plaques that cause heart disease. In this study, a mathematical mo...

    Authors: Emma Saxon
    Citation: BMC Biology 2015 13:62
  9. Some steroid drugs are designed for clinical use to combat muscle-wasting diseases, but are also used by athletes to improve their performance by increasing muscle strength or endurance. This study investigate...

    Authors: Emma Saxon
    Citation: BMC Biology 2015 13:61
  10. Probiotic treatments are thought to increase the levels of commensal bacterial species that populate the human gut, causing no harm to their host and playing an important role in maintaining gut health. This s...

    Authors: Emma Saxon
    Citation: BMC Biology 2015 13:60
  11. Peptide transporters are membrane proteins that mediate the cellular uptake of di- and tripeptides, and of peptidomimetic drugs such as β-lactam antibiotics, antiviral drugs and antineoplastic agents. In spite...

    Authors: Rajendra Boggavarapu, Jean-Marc Jeckelmann, Daniel Harder, Zöhre Ucurum and Dimitrios Fotiadis
    Citation: BMC Biology 2015 13:58
  12. The functional consequences of whole genome duplications in vertebrate evolution are not fully understood. It remains unclear, for instance, why paralogues were retained in some gene families but extensively l...

    Authors: Ferdinand Marlétaz, Ignacio Maeso, Laura Faas, Harry V. Isaacs and Peter W. H. Holland
    Citation: BMC Biology 2015 13:56
  13. The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and...

    Authors: Ho-Su Sin, Andrey V. Kartashov, Kazuteru Hasegawa, Artem Barski and Satoshi H. Namekawa
    Citation: BMC Biology 2015 13:53
  14. Qualitative and quantitative measurements of motor performance are essential for characterizing perturbations of motor systems. Although several methods exist for analyzing specific motor tasks, few behavioral...

    Authors: César S. Mendes, Imre Bartos, Zsuzsanna Márka, Turgay Akay, Szabolcs Márka and Richard S. Mann
    Citation: BMC Biology 2015 13:50
  15. Malaria invasion of red blood cells involves multiple parasite-specific targets that are easily accessible to inhibitory compounds, making it an attractive target for antimalarial development. However, no curr...

    Authors: Danny W Wilson, Christopher D Goodman, Brad E Sleebs, Greta E Weiss, Nienke WM de Jong, Fiona Angrisano, Christine Langer, Jake Baum, Brendan S Crabb, Paul R Gilson, Geoffrey I McFadden and James G Beeson
    Citation: BMC Biology 2015 13:52
  16. Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear which strategies they follow to fulfill that performance objective. Slow cycling of stem cells pr...

    Authors: Michael Chiang, Amanda Cinquin, Adrian Paz, Edward Meeds, Christopher A. Price, Max Welling and Olivier Cinquin
    Citation: BMC Biology 2015 13:51
  17. Development and evaluation of new insect pest management tools is critical for overcoming over-reliance upon, and growing resistance to, synthetic, biological and plant-expressed insecticides. For transgenic c...

    Authors: Tim Harvey-Samuel, Neil I. Morrison, Adam S. Walker, Thea Marubbi, Ju Yao, Hilda L. Collins, Kevin Gorman, T. G. Emyr Davies, Nina Alphey, Simon Warner, Anthony M. Shelton and Luke Alphey
    Citation: BMC Biology 2015 13:49
  18. Genetic ablation of target cells is a powerful tool to study the origins and functions of cells, tissue regeneration, or pathophysiology in a human disease model in vivo. Several methods for selective cell ablati...

    Authors: Fumiaki Obata, Shiho Tanaka, Soshiro Kashio, Hidenobu Tsujimura, Ryoichi Sato and Masayuki Miura
    Citation: BMC Biology 2015 13:48
  19. Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological...

    Authors: Ewa K. Paluch, Celeste M. Nelson, Nicolas Biais, Ben Fabry, Jens Moeller, Beth L. Pruitt, Carina Wollnik, Galina Kudryasheva, Florian Rehfeldt and Walter Federle
    Citation: BMC Biology 2015 13:47
  20. Plants are able to sense UV-B through the UV-B photoreceptor UVR8. UV-B photon absorption by a UVR8 homodimer leads to UVR8 monomerization and interaction with the downstream signaling factor COP1. This then i...

    Authors: Roman Ulm and Gareth I Jenkins
    Citation: BMC Biology 2015 13:45
  21. In many insect species, fitness trade-offs exist between maximizing body size and developmental speed. Understanding how various species evolve different life history strategies requires knowledge of the physi...

    Authors: Nicole E. Hatem, Zhou Wang, Keelin B. Nave, Takashi Koyama and Yuichiro Suzuki
    Citation: BMC Biology 2015 13:44
  22. Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination...

    Authors: Jennifer A. Evans, Ting-Chung Suen, Ben L. Callif, Andrew S. Mitchell, Oscar Castanon-Cervantes, Kimberly M. Baker, Ian Kloehn, Kenkichi Baba, Brett J. W. Teubner, J. Christopher Ehlen, Ketema N. Paul, Timothy J. Bartness, Gianluca Tosini, Tanya Leise and Alec J. Davidson
    Citation: BMC Biology 2015 13:43
  23. Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggre...

    Authors: Yongfeng Luo, Elie El Agha, Gianluca Turcatel, Hui Chen, Joanne Chiu, David Warburton, Saverio Bellusci, Bang-Ping Qian, Douglas B. Menke and Wei Shi
    Citation: BMC Biology 2015 13:42
  24. We report here the first genome-wide high-resolution polymorphism resource for non-human primate (NHP) association and linkage studies, constructed for the Caribbean-origin vervet monkey, or African green monk...

    Authors: Yu S. Huang, Vasily Ramensky, Susan K. Service, Anna J. Jasinska, Yoon Jung, Oi-Wa Choi, Rita M. Cantor, Nikoleta Juretic, Jessica Wasserscheid, Jay R. Kaplan, Matthew J. Jorgensen, Thomas D. Dyer, Ken Dewar, John Blangero, Richard K. Wilson, Wesley Warren…
    Citation: BMC Biology 2015 13:41
  25. The early stages of ovarian follicle formation—beginning with the breakdown of germ cell cysts and continuing with the formation of primordial follicles and transition to primary and secondary follicles—are cr...

    Authors: Yu Ren, Hitomi Suzuki, Krishna Jagarlamudi, Kayla Golnoski, Megan McGuire, Rita Lopes, Vassilis Pachnis and Aleksandar Rajkovic
    Citation: BMC Biology 2015 13:39
  26. Chromosomes reorganize in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localize to the nuclear periphery via interaction of the telomeric protein Rap1 with the mem...

    Authors: Hanna Amelina, Shaan Subramaniam, Vera Moiseeva, Christine Anne Armstrong, Siân Rosanna Pearson and Kazunori Tomita
    Citation: BMC Biology 2015 13:37
  27. Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing reg...

    Authors: Eneritz Agirre, Nicolás Bellora, Mariano Alló, Amadís Pagès, Paola Bertucci, Alberto R Kornblihtt and Eduardo Eyras
    Citation: BMC Biology 2015 13:31
  28. Photoreceptor degeneration is a main hallmark of many blinding diseases making protection of photoreceptors crucial to prevent vision loss. Thus, regulation of endogenous neuroprotective factors may be key for...

    Authors: Cavit Agca, Karsten Boldt, Andrea Gubler, Isabelle Meneau, Armelle Corpet, Marijana Samardzija, Manuel Stucki, Marius Ueffing and Christian Grimm
    Citation: BMC Biology 2015 13:30
  29. The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut...

    Authors: José M Martín-Durán and Andreas Hejnol
    Citation: BMC Biology 2015 13:29
  30. Jasmonates are well known plant signaling components required for stress responses and development. A prominent feature of jasmonate biosynthesis or signaling mutants is the loss of fertility. In contrast to t...

    Authors: Susanne Dobritzsch, Martin Weyhe, Ramona Schubert, Julian Dindas, Gerd Hause, Joachim Kopka and Bettina Hause
    Citation: BMC Biology 2015 13:28
  31. Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca2+-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of compl...

    Authors: Umakhanth Venkatraman Girija, Christopher M Furze, Alexandre R Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie E Marshall, A Katrine Wallis, Wilhelm J Schwaeble, Mohammed El-Mezgueldi, Daniel A Mitchell, Peter CE Moody, Nobutaka Wakamiya and Russell Wallis
    Citation: BMC Biology 2015 13:27
  32. Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a ge...

    Authors: Luis A Aguirre, M Eva Alonso, Claudio Badía-Careaga, Isabel Rollán, Cristina Arias, Ana Fernández-Miñán, Elena López-Jiménez, Amelia Aránega, José Luis Gómez-Skarmeta, Diego Franco and Miguel Manzanares
    Citation: BMC Biology 2015 13:26
  33. Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one of the main driving factors of human malignancies. They function as transcription factors that (i...

    Authors: Eva K Herter, Maria Stauch, Maria Gallant, Elmar Wolf, Thomas Raabe and Peter Gallant
    Citation: BMC Biology 2015 13:25
  34. Fixation of beneficial genes in bacteria and archaea (collectively, prokaryotes) is often believed to erase pre-existing genomic diversity through the hitchhiking effect, a phenomenon known as genome-wide sele...

    Authors: Nobuto Takeuchi, Otto X Cordero, Eugene V Koonin and Kunihiko Kaneko
    Citation: BMC Biology 2015 13:20
  35. The pilidium larva is a novel body plan that arose within a single clade in the phylum Nemertea - the Pilidiophora. While the sister clade of the Pilidiophora and the basal nemerteans develop directly, pilidio...

    Authors: Laurel S Hiebert and Svetlana A Maslakova
    Citation: BMC Biology 2015 13:23
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