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  1. The development of nanoscale secondary ion mass spectrometry (NanoSIMS) has revolutionized the study of biological tissues by enabling, e.g., the visualization and quantification of metabolic processes at subc...

    Authors: Anders Meibom, Florent Plane, Tian Cheng, Gilles Grandjean, Olivier Haldimann, Stephane Escrig, Louise Jensen, Jean Daraspe, Antonio Mucciolo, Damien De Bellis, Nils Rädecker, Cristina Martin-Olmos, Christel Genoud and Arnaud Comment
    Citation: BMC Biology 2023 21:126
  2. Intracellular symbionts often undergo genome reduction, losing both coding and non-coding DNA in a process that ultimately produces small, gene-dense genomes with few genes. Among eukaryotes, an extreme exampl...

    Authors: Vojtečh Žárský, Anna Karnkowska, Vittorio Boscaro, Morelia Trznadel, Thomas A. Whelan, Markus Hiltunen-Thorén, Ioana Onut-Brännström, Cathryn L. Abbott, Naomi M. Fast, Fabien Burki and Patrick J. Keeling
    Citation: BMC Biology 2023 21:137
  3. Snake venoms are trophic adaptations that represent an ideal model to examine the evolutionary factors that shape polymorphic traits under strong natural selection. Venom compositional variation is substantial...

    Authors: Cara F. Smith, Zachary L. Nikolakis, Kathleen Ivey, Blair W. Perry, Drew R. Schield, Neil R. Balchan, Joshua Parker, Kirk C. Hansen, Anthony J. Saviola, Todd A. Castoe and Stephen P. Mackessy
    Citation: BMC Biology 2023 21:136
  4. Based on their anatomical location, rostral projections of nuclei are classified as ascending circuits, while caudal projections are classified as descending circuits. Upper brainstem neurons participate in co...

    Authors: Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong and Xiangning Li
    Citation: BMC Biology 2023 21:135
  5. Sapria himalayana (Rafflesiaceae) is an endoparasitic plant characterized by a greatly reduced vegetative body and giant flowers; however, the mechanisms underlying its special lifestyle and greatly altered plant...

    Authors: Xuelian Guo, Xiaodi Hu, Jianwu Li, Bingyi Shao, Yajun Wang, Long Wang, Kui Li, Dongliang Lin, Hanchen Wang, Zhiyuan Gao, Yuannian Jiao, Yingying Wen, Hongyu Ji, Chongbo Ma, Song Ge, Wenkai Jiang…
    Citation: BMC Biology 2023 21:134
  6. With the urgent need to reduce carbon emissions, and the dwindling reserves of easily exploitable fossil fuel, microalgae-based biofuels that can be used for transport systems and CO2 abatement have attracted gre...

    Authors: Baoyan Gao, Meng Xu, Dai Shan, Chi Zhang, Yulan Yang, Zhensheng Dong, Hu Zhang, Boping Han, Luodong Huang and Chengwu Zhang
    Citation: BMC Biology 2023 21:133
  7. Non-invasive recordings of gross neural activity in humans often show responses to omitted stimuli in steady trains of identical stimuli. This has been taken as evidence for the neural coding of prediction or ...

    Authors: Ryszard Auksztulewicz, Vani Gurusamy Rajendran, Fei Peng, Jan Wilbert Hendrik Schnupp and Nicol Spencer Harper
    Citation: BMC Biology 2023 21:130
  8. Common seadragons (Phyllopteryx taeniolatus, Syngnathidae) are an emblem of the diverse endemic fauna of Australia’s southern rocky reefs, the newly recognized “Great Southern Reef.” A lack of assessments spannin...

    Authors: Josefin Stiller, Nerida G. Wilson and Greg W. Rouse
    Citation: BMC Biology 2023 21:129
  9. Circular RNA (circRNA) molecules, generated through non-canonical back-splicing of exon-exon junctions, have recently been implicated in diverse biological functions including transcriptional regulation and mo...

    Authors: Michelle E. Watts, Marika Oksanen, Sanna Lejerkrans, Francesca Mastropasqua, Myriam Gorospe and Kristiina Tammimies
    Citation: BMC Biology 2023 21:127
  10. Information on common markers of metabolic resistance in malaria vectors from countries sharing similar eco-climatic characteristics can facilitate coordination of malaria control. Here, we characterized popul...

    Authors: Sulaiman S. Ibrahim, Abdullahi Muhammad, Jack Hearn, Gareth D. Weedall, Sanjay C. Nagi, Muhammad M. Mukhtar, Amen N. Fadel, Leon J. Mugenzi, Edward I. Patterson, Helen Irving and Charles S. Wondji
    Citation: BMC Biology 2023 21:125
  11. The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglut...

    Authors: Yujuan Wang, Yuan Zhang, Xinyu Guo, Yiqiang Zheng, Xinjie Zhang, Shanshan Feng and Hui-Yuan Wu
    Citation: BMC Biology 2023 21:124
  12. Changes in gene expression levels during brain development are thought to have played an important role in the evolution of human cognition. With the advent of high-throughput sequencing technologies, changes ...

    Authors: Weifen Sun, Gangcai Xie, Xi Jiang, Philipp Khaitovich, Dingding Han and Xiling Liu
    Citation: BMC Biology 2023 21:123
  13. The factors that maintain phenotypic and genetic variation within a population have received long-term attention in evolutionary biology. Here the genetic basis and evolution of the geographically widespread v...

    Authors: Guilian Huang, Wei Wu, Yongmei Chen, Xueke Zhi, Peishan Zou, Zulin Ning, Qiang Fan, Ying Liu, Shulin Deng, Kai Zeng and Renchao Zhou
    Citation: BMC Biology 2023 21:122
  14. The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such pepti...

    Authors: Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A. B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C. C. Wai, Victoria L. Coyne, Matthew J. Phillips…
    Citation: BMC Biology 2023 21:121
  15. The regulation of glycolysis and autophagy during feeding and metamorphosis in holometabolous insects is a complex process that is not yet fully understood. Insulin regulates glycolysis during the larval feedi...

    Authors: Xin-Le Kang, Yan-Xue Li, Du-Juan Dong, Jin-Xing Wang and Xiao-Fan Zhao
    Citation: BMC Biology 2023 21:119
  16. Pseudozyma flocculosa is a highly efficient biocontrol agent (BCA) of powdery mildews whose mode of action remains elusive. It is known to secrete unique effectors during its interaction with powdery mildews but ...

    Authors: Parthasarathy Santhanam, Mst Hur Madina, Fernanda Matias Albuini, Caroline Labbé, Luciano Gomes Fietto and Richard R. Bélanger
    Citation: BMC Biology 2023 21:118
  17. A fraction of all genomes is composed of transposable elements (TEs) whose mobility needs to be carefully controlled. In gonads, TE activity is repressed by PIWI-interacting RNAs (piRNAs), a class of small RNA...

    Authors: Amna Asif-Laidin, Karine Casier, Zoheir Ziriat, Antoine Boivin, Elise Viodé, Valérie Delmarre, Stéphane Ronsseray, Clément Carré and Laure Teysset
    Citation: BMC Biology 2023 21:117
  18. Post mortem human brain tissue is an essential resource to study cell types, connectivity as well as subcellular structures down to the molecular setup of the central nervous system especially with respect to the...

    Authors: Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Heiko Braak, Kelly Del Tredici, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers and Michael Schön
    Citation: BMC Biology 2023 21:113
  19. Canadian policymakers are interested in determining whether farmed Atlantic salmon, frequently infected with Piscine orthoreovirus (PRV), may threaten wild salmon populations in the Pacific Northwest. A relevant ...

    Authors: Shinichi Nakagawa and Malgorzata Lagisz
    Citation: BMC Biology 2023 21:116

    The original article was published in BMC Biology 2021 19:138

    The Correspondence to this article has been published in BMC Biology 2023 21:114

    The Correspondence to this article has been published in BMC Biology 2023 21:115

  20. Authors: Mark P. Polinski, Yangfan Zhang, Phillip R. Morrison, Gary D. Marty, Colin J. Brauner, Anthony P. Farrell and Kyle A. Garver
    Citation: BMC Biology 2023 21:115

    The original article was published in BMC Biology 2021 19:138

    The Commentary to this article has been published in BMC Biology 2023 21:116

    The Correspondence to this article has been published in BMC Biology 2023 21:114

  21. This paper is a response to Polinski, M. P. et al. Innate antiviral defense demonstrates high energetic efficiency in a bony fish. BMC Biology 19, 138 (2021).

    Authors: Gideon Mordecai, Arthur L. Bass, Rick Routledge, Emiliano Di Cicco, Amy Teffer, Christoph Deeg, Andrew W. Bateman and Kristina M. Miller
    Citation: BMC Biology 2023 21:114

    The Commentary to this article has been published in BMC Biology 2023 21:116

    The Correspondence to this article has been published in BMC Biology 2023 21:115

    The Research article to this article has been published in BMC Biology 2021 19:138

  22. Mitochondria have a central role in cellular functions, aging, and in certain diseases. They possess their own genome, a vestige of their bacterial ancestor. Over the course of evolution, most of the genes of ...

    Authors: Laura Kienzle, Stefano Bettinazzi, Thierry Choquette, Marie Brunet, Hajar Hosseini Khorami, Jean-François Jacques, Mathilde Moreau, Xavier Roucou, Christian R. Landry, Annie Angers and Sophie Breton
    Citation: BMC Biology 2023 21:111
  23. DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA me...

    Authors: Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen and Lumir Krejci
    Citation: BMC Biology 2023 21:110
  24. The Western mosquitofish, Gambusia affinis, is a model for sex chromosome organization and evolution of female heterogamety. We previously identified a G. affinis female-specific marker, orthologous to the aminom...

    Authors: Stefan Müller, Kang Du, Yann Guiguen, Maria Pichler, Shinichi Nakagawa, Matthias Stöck, Manfred Schartl and Dunja K. Lamatsch
    Citation: BMC Biology 2023 21:109
  25. Finding the optimal balance between survival and reproduction is a central puzzle in life-history theory. The terminal investment hypothesis predicts that when individuals encounter a survival threat that comp...

    Authors: Yong Zhi Foo, Malgorzata Lagisz, Rose E. O’Dea and Shinichi Nakagawa
    Citation: BMC Biology 2023 21:107
  26. Anthocyanins, a class of specialized metabolites that are ubiquitous among plant species, have attracted a great deal of attention from plant biologists due to their chemical diversity. They confer purple, pin...

    Authors: Muhammad Ali Abid, Qi Zhou, Mubashir Abbas, Haiyan He, Zhigang Meng, Yuan Wang, Yunxiao Wei, Sandui Guo, Rui Zhang and Chengzhen Liang
    Citation: BMC Biology 2023 21:106
  27. Hybrids are chimeric organisms with highly plastic heterozygous genomes that may confer unique traits enabling the adaptation to new environments. However, most evolutionary theory frameworks predict that the ...

    Authors: Verónica Mixão, Juan Carlos Nunez-Rodriguez, Valentina del Olmo, Ewa Ksiezopolska, Ester Saus, Teun Boekhout, Attila Gacser and Toni Gabaldón
    Citation: BMC Biology 2023 21:105
  28. Gene duplication events are critical for the evolution of new gene functions. Aristaless is a major regulator of distinct developmental processes. It is most known for its role during appendage development acr...

    Authors: Erick X. Bayala, Isabella Cisneros, Darli Massardo, Nicholas W. VanKuren and Marcus R. Kronforst
    Citation: BMC Biology 2023 21:104
  29. Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, b...

    Authors: Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond…
    Citation: BMC Biology 2023 21:103
  30. Horizontal gene transfer (HGT) is an evolutionary mechanism of adaptive importance, which has been deeply studied in wine S. cerevisiae strains, where those acquired genes conferred improved traits related to bot...

    Authors: Sebastián M. Tapia, Laura G. Macías, Roberto Pérez-Torrado, Noemi Daroqui, Paloma Manzanares, Amparo Querol and Eladio Barrio
    Citation: BMC Biology 2023 21:102
  31. Through the evolution of novel wing structures, bats (Order Chiroptera) became the only mammalian group to achieve powered flight. This achievement preceded the massive adaptive radiation of bats into diverse ...

    Authors: Neal Anthwal, Daniel J. Urban, Alexa Sadier, Risa Takenaka, Simon Spiro, Nancy Simmons, Richard R. Behringer, Chris J. Cretekos, John J. Rasweiler IV and Karen E. Sears
    Citation: BMC Biology 2023 21:101
  32. Highly diverse butterfly wing patterns have emerged as a powerful system for understanding the genetic basis of phenotypic variation. While the genetic basis of this pattern variation is being clarified, the p...

    Authors: Erick X. Bayala, Nicholas VanKuren, Darli Massardo and Marcus R. Kronforst
    Citation: BMC Biology 2023 21:100
  33. Diplonemid flagellates are among the most abundant and species-rich of known marine microeukaryotes, colonizing all habitats, depths, and geographic regions of the world ocean. However, little is known about t...

    Authors: Matus Valach, Sandrine Moreira, Celine Petitjean, Corinna Benz, Anzhelika Butenko, Olga Flegontova, Anna Nenarokova, Galina Prokopchuk, Tom Batstone, Pascal Lapébie, Lionnel Lemogo, Matt Sarrasin, Paul Stretenowich, Pragya Tripathi, Euki Yazaki, Takeshi Nara…
    Citation: BMC Biology 2023 21:99
  34. Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogen...

    Authors: Sanjana Rajan, Emily M. Franz, Camille A. McAloney, Tatyana A. Vetter, Maren Cam, Amy C. Gross, Cenny Taslim, Meng Wang, Matthew V. Cannon, Alexander Oles and Ryan D. Roberts
    Citation: BMC Biology 2023 21:98
  35. Aedes aegypti, the main arboviral mosquito vector, is attracted to human dwellings and makes use of human-generated breeding sites. Past research has shown that bacterial communities associated with such sites un...

    Authors: Katherine D. Mosquera, Luis Eduardo Martínez Villegas, Gabriel Rocha Fernandes, Mariana Rocha David, Rafael Maciel-de-Freitas, Luciano A. Moreira and Marcelo G. Lorenzo
    Citation: BMC Biology 2023 21:97
  36. Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in T...

    Authors: Laura Mundrucz, Angéla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens and Miklós Kecskés
    Citation: BMC Biology 2023 21:96
  37. Natronobacterium gregoryi Argonaute (NgAgo) was found to reduce mRNA without generating detectable DNA double-strand breaks in a couple of endogenous genes in zebrafish, suggesting its potential as a tool for gen...

    Authors: Zhangji Dong, Xu Chen, Run Zhuo, Yuanyuan Li, Zhihao Zhou, Ying Sun, Yan Liu and Mei Liu
    Citation: BMC Biology 2023 21:95
  38. Circular RNAs (circRNAs) are a large class of mammalian RNAs. Several protein products translated by circRNAs have been reported to be involved in the development of various tissues and systems; however, their...

    Authors: Shu Zhang, Chang Wang, Yue Wang, Hao Zhang, Chen Xu, Yiwei Cheng, Yan Yuan, Jiahao Sha, Xuejiang Guo and Yiqiang Cui
    Citation: BMC Biology 2023 21:94
  39. RNA 5-methyluridine (m5U) modifications are obtained by methylation at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is related to the development of human diseases. Accurate i...

    Authors: Chunyan Ao, Xiucai Ye, Tetsuya Sakurai, Quan Zou and Liang Yu
    Citation: BMC Biology 2023 21:93
  40. Rice grain size (GS) is an essential agronomic trait. Though several genes and miRNA modules influencing GS are known and seed development transcriptomes analyzed, a comprehensive compendium connecting all pos...

    Authors: Arunima Mahto, Antima Yadav, Aswathi P. V., Swarup K. Parida, Akhilesh K. Tyagi and Pinky Agarwal
    Citation: BMC Biology 2023 21:91
  41. Anti-inflammatory therapy is an effective strategy in the treatment of type 2 diabetes (T2D). Studies found that inflammatory responses in vivo were strongly associated with defects in the mucosal barrier func...

    Authors: Deliang Liu, Shaobao Zhang, Siju Li, Qian Zhang, Ying Cai, Pei Li, Hao Li, Baochun Shen, Qiongfeng Liao, Yanjun Hong and Zhiyong Xie
    Citation: BMC Biology 2023 21:90
  42. Among six extant tiger subspecies, the South China tiger (Panthera tigris amoyensis) once was widely distributed but is now the rarest one and extinct in the wild. All living South China tigers are descendants of...

    Authors: Chen Wang, Dong-Dong Wu, Yao-Hua Yuan, Meng-Cheng Yao, Jian-Lin Han, Ya-Jiang Wu, Fen Shan, Wan-Ping Li, Jun-Qiong Zhai, Mian Huang, Shi-Ming Peng, Qin-Hui Cai, Jian-Yi Yu, Qun-Xiu Liu, Zhao-Yang Liu, Lin-Xiang Li…
    Citation: BMC Biology 2023 21:64
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