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  1. Dimorphism, the ability to switch between a ‘yeast-like’ and a hyphal growth form, is an important feature of certain fungi, including important plant and human pathogens. The switch to hyphal growth is often ...

    Authors: Andrea Kovács-Simon and Helen N. Fones
    Citation: BMC Biology 2024 22:10
  2. SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets agains...

    Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer and Katrin Paeschke
    Citation: BMC Biology 2024 22:5
  3. The common carp (Cyprinus carpio) might best represent the domesticated allopolyploid animals. Although subgenome divergence which is well-known to be a key to allopolyploid domestication has been comprehensively...

    Authors: Min Wang, Xinxin Li, Chongnv Wang, Ming Zou, Jing Yang, Xiang-dong Li and Baocheng Guo
    Citation: BMC Biology 2024 22:4
  4. Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and...

    Authors: Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson and Helen L. Fitzsimons
    Citation: BMC Biology 2024 22:2
  5. Cell senescence is a sign of aging and plays a significant role in the pathogenesis of age-related disorders. For cell therapy, senescence may compromise the quality and efficacy of cells, posing potential saf...

    Authors: Liangge He, Mingzhu Li, Xinglie Wang, Xiaoyan Wu, Guanghui Yue, Tianfu Wang, Yan Zhou, Baiying Lei and Guangqian Zhou
    Citation: BMC Biology 2024 22:1
  6. The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose questions on how much is currently known ab...

    Authors: Lydia Teboul, Yann Hérault, Sara Wells and Guillaume Pavlovic
    Citation: BMC Biology 2023 21:301
  7. Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D organoid cultures in non-model animals, such as dogs....

    Authors: Karin Allenspach, Yana Zavros, Mohamed Elbadawy, Christopher Zdyrski and Jonathan Paul Mochel
    Citation: BMC Biology 2023 21:297
  8. Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics...

    Authors: Margherita De Marzio, Kimberly Glass and Marieke L. Kuijjer
    Citation: BMC Biology 2023 21:296
  9. Identifying the key factors that underlie complex traits during domestication is a great challenge for evolutionary and biological studies. In addition to the protein-coding region differences caused by varian...

    Authors: Zhong-Tao Yin, Xiao-Qin Li, Yun-Xiao Sun, Jacqueline Smith, Maxwell Hincke, Ning Yang and Zhuo-Cheng Hou
    Citation: BMC Biology 2023 21:303
  10. Alzheimer’s disease (AD) is the most common neurodegenerative disorder with clinical presentations of progressive cognitive and memory deterioration. The pathologic hallmarks of AD include tau neurofibrillary ...

    Authors: Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin and Shu-Chun Teng
    Citation: BMC Biology 2023 21:293
  11. Olfactory sensory neurons detect odourants via multiple long cilia that protrude from their dendritic endings. The G protein-coupled receptor GPRC5C was identified as part of the olfactory ciliary membrane pro...

    Authors: Sneha Bhat, André Dietz, Katja Senf, Sandor Nietzsche, Yoshio Hirabayashi, Martin Westermann and Eva Maria Neuhaus
    Citation: BMC Biology 2023 21:292
  12. Rhabdomeric photoreceptors of eyes in the terrestrial slug Limax are the typical invertebrate-type but unique in that three visual opsins (Gq-coupled rhodopsin, xenopsin, Opn5A) and one retinochrome, all belongin...

    Authors: Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo and Akihisa Terakita
    Citation: BMC Biology 2023 21:291
  13. Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nu...

    Authors: Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry and Mary Kathryn Sewell-Loftin
    Citation: BMC Biology 2023 21:290
  14. Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotect...

    Authors: Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger and Adam R. Konopka
    Citation: BMC Biology 2023 21:287
  15. Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and agricultural species. Genotyping-by-sequencing, a method which uses low-coverage sequen...

    Authors: H. J. Lamb, L. T. Nguyen, J. P. Copley, B. N. Engle, B. J. Hayes and E. M. Ross
    Citation: BMC Biology 2023 21:286
  16. Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM ...

    Authors: Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang and Ran Huo
    Citation: BMC Biology 2023 21:285
  17. Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remain a conspicuous gap in molecular studies of marine adaptation in vertebrates.

    Authors: Alastair J. Ludington, Jillian M. Hammond, James Breen, Ira W. Deveson and Kate L. Sanders
    Citation: BMC Biology 2023 21:284
  18. Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. These levels of organisation all exist within the same system, with diversity patterns eme...

    Authors: Thomas Keggin, Conor Waldock, Alexander Skeels, Oskar Hagen, Camille Albouy, Stéphanie Manel and Loïc Pellissier
    Citation: BMC Biology 2023 21:282
  19. Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fg...

    Authors: Rheannon O. Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie and Patrick S. Western
    Citation: BMC Biology 2023 21:281
  20. Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal mi...

    Authors: Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang and Weihong Jiang
    Citation: BMC Biology 2023 21:280
  21. The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasites is rarely studied. Divalent metal transporter (DMT1) is a critical iron transporter...

    Authors: Mengjiao Zhong and Bing Zhou
    Citation: BMC Biology 2023 21:279
  22. Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.

    Authors: Madeleine Birgersson, Rajitha Indukuri, Linnéa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer and Cecilia Williams
    Citation: BMC Biology 2023 21:277
  23. Many organisms rely on mineral nutrients taken directly from the soil or aquatic environment, and therefore, developed mechanisms to cope with the limitation of a given essential nutrient. For example, photosy...

    Authors: Stéphanie Bolik, Alexander Schlaich, Tetiana Mukhina, Alberto Amato, Olivier Bastien, Emanuel Schneck, Bruno Demé and Juliette Jouhet
    Citation: BMC Biology 2023 21:275
  24. Aedes aegypti (Ae. aegypti) is the major vector that transmits many diseases including dengue, Zika, and filariasis in tropical and subtropical regions. Due to the growing resistance to chemical-based insecticide...

    Authors: Heng Zhang, Emma Trueman, Xinjun Hou, De Xian Chew, Lu Deng, Jonathan Liew, Tania Chia, Zhiyong Xi, Cheong Huat Tan and Yu Cai
    Citation: BMC Biology 2023 21:274
  25. Sex differences in microRNA (miRNA) expression profiles have been found across multiple tissues. Skeletal muscle is one of the most sex-biased tissues of the body. MiRNAs are necessary for development and have...

    Authors: Danielle Hiam, Shanie Landen, Macsue Jacques, Sarah Voisin, Séverine Lamon and Nir Eynon
    Citation: BMC Biology 2023 21:273
  26. Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While a plethora of studies have connected a significant fraction of human D...

    Authors: Dongyang Xu, Lu Tang, Junjun Zhou, Fang Wang, Huifen Cao, Yu Huang and Philipp Kapranov
    Citation: BMC Biology 2023 21:271
  27. Microbiome analysis is becoming a standard component in many scientific studies, but also requires extensive quality control of the 16S rRNA gene sequencing data prior to analysis. In particular, when investig...

    Authors: Claudia Hülpüsch, Luise Rauer, Thomas Nussbaumer, Vera Schwierzeck, Madhumita Bhattacharyya, Veronika Erhart, Claudia Traidl-Hoffmann, Matthias Reiger and Avidan U. Neumann
    Citation: BMC Biology 2023 21:269
  28. Mayflies are basal winged insects of crucial importance for the understanding of the early evolution of Pterygota. Unlike all other insects, they have two successive winged stages, the subimago and the imago. ...

    Authors: Eduardo Domínguez, Thomas van de Kamp, István Mikó, M. Gabriela Cuezzo and Arnold H. Staniczek
    Citation: BMC Biology 2023 21:268
  29. The red junglefowl, the wild outgroup of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of c...

    Authors: Edward S. Rice, Antton Alberdi, James Alfieri, Giridhar Athrey, Jennifer R. Balacco, Philippe Bardou, Heath Blackmon, Mathieu Charles, Hans H. Cheng, Olivier Fedrigo, Steven R. Fiddaman, Giulio Formenti, Laurent A. F. Frantz, M. Thomas P. Gilbert, Cari J. Hearn, Erich D. Jarvis…
    Citation: BMC Biology 2023 21:267
  30. Unlike most free-living platyhelminths, catenulids, the sister group to all remaining flatworms, do not have eyes. Instead, the most prominent sensory structures in their heads are statocysts or sensory pits. ...

    Authors: Ludwik Gąsiorowski, Isabel Lucia Dittmann, Jeremias N. Brand, Torben Ruhwedel, Wiebke Möbius, Bernhard Egger and Jochen C. Rink
    Citation: BMC Biology 2023 21:266
  31. Lepidoptera is one of the most species-rich animal groups, with substantial karyotype variations among species due to chromosomal rearrangements. Knowledge of the evolutionary patterns of lepidopteran chromoso...

    Authors: Xi Chen, Zuoqi Wang, Chaowei Zhang, Jingheng Hu, Yueqi Lu, Hang Zhou, Yang Mei, Yuyang Cong, Fangyuan Guo, Yaqin Wang, Kang He, Ying Liu and Fei Li
    Citation: BMC Biology 2023 21:265
  32. Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating c...

    Authors: Miao Wang, Bing He, Yueling Hao, Divyaa Srinivasan, Jatin Shrinet and Peter Fraser
    Citation: BMC Biology 2023 21:264
  33. RNA editing by adenosine deaminase acting on RNA (ADAR) occurs in all metazoans and fulfils several functions. Here, we examined effects of acclimation temperature (27 °C, 18 °C,13 °C) on editing patterns in six ...

    Authors: Wenhao Li, Mengdi Bu, Ruiqin Hu, Shouwen Jiang, Liangbiao Chen and George N. Somero
    Citation: BMC Biology 2023 21:262
  34. Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activi...

    Authors: Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis and Thomas Klein
    Citation: BMC Biology 2023 21:260
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