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  1. Circular RNAs (circRNAs) have been confirmed to play a vital role in the occurrence and development of diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significance for stu...

    Authors: Mengting Niu, Chunyu Wang, Zhanguo Zhang and Quan Zou
    Citation: BMC Biology 2024 22:24
    Content type: Research article Published on:

  5. The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South...

    Authors: Guanglin He, Peixin Wang, Jing Chen, Yan Liu, Yuntao Sun, Rong Hu, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Libing Yun, Liping Hu, Jiangwei Yan, Shengjie Nie, Lanhai Wei…
    Citation: BMC Biology 2024 22:18
    Content type: Research article Published on:

  6. Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk ti...

    Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk and Jonathan Mill
    Citation: BMC Biology 2024 22:17
    Content type: Research article Published on:

  7. Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differ...

    Authors: Sergei S. Ryazansky, Chujia Chen, Mark Potters, Anastasia N. Naumenko, Varvara Lukyanchikova, Reem A. Masri, Ilya I. Brusentsov, Dmitriy A. Karagodin, Andrey A. Yurchenko, Vitor L. dos Anjos, Yuki Haba, Noah H. Rose, Jinna Hoffman, Rong Guo, Theresa Menna, Melissa Kelley…
    Citation: BMC Biology 2024 22:16
    Content type: Research article Published on:

  9. Mosquito borne viruses, such as dengue, Zika, yellow fever and Chikungunya, cause millions of infections every year. These viruses are mostly transmitted by two urban-adapted mosquito species, Aedes aegypti and A...

    Authors: Carlos F. Estevez-Castro, Murillo F. Rodrigues, Antinéa Babarit, Flávia V. Ferreira, Elisa G. de Andrade, Eric Marois, Rodrigo Cogni, Eric R. G. R. Aguiar, João T. Marques and Roenick P. Olmo
    Citation: BMC Biology 2024 22:14
    Content type: Research article Published on:

  10. Single-nucleotide polymorphisms (SNPs) are the most widely used form of molecular genetic variation studies. As reference genomes and resequencing data sets expand exponentially, tools must be in place to call...

    Authors: Yong Zhou, Nagarajan Kathiresan, Zhichao Yu, Luis F. Rivera, Yujian Yang, Manjula Thimma, Keerthana Manickam, Dmytro Chebotarov, Ramil Mauleon, Kapeel Chougule, Sharon Wei, Tingting Gao, Carl D. Green, Andrea Zuccolo, Weibo Xie, Doreen Ware…
    Citation: BMC Biology 2024 22:13
    Content type: Methodology article Published on:

  11. Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...

    Authors: Huazhang Zhu, Dawei Wang, Zuodong Ye, Lihong Huang, Wenjie Wei, Kui Ming Chan, Rongxin Zhang, Liang Zhang and Jianbo Yue
    Citation: BMC Biology 2024 22:12
    Content type: Research article Published on:

  12. The remarkable resistance to ionizing radiation found in anhydrobiotic organisms, such as some bacteria, tardigrades, and bdelloid rotifers has been hypothesized to be incidental to their desiccation resistanc...

    Authors: Victoria C. Moris, Lucie Bruneau, Jérémy Berthe, Anne-Catherine Heuskin, Sébastien Penninckx, Sylvia Ritter, Uli Weber, Marco Durante, Etienne G. J. Danchin, Boris Hespeels and Karine Van Doninck
    Citation: BMC Biology 2024 22:11
    Content type: Research article Published on:

  13. Dimorphism, the ability to switch between a ‘yeast-like’ and a hyphal growth form, is an important feature of certain fungi, including important plant and human pathogens. The switch to hyphal growth is often ...

    Authors: Andrea Kovács-Simon and Helen N. Fones
    Citation: BMC Biology 2024 22:10
    Content type: Methodology article Published on:

  14. How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processe...

    Authors: Jessica A. Goodheart, Robin A. Rio, Neville F. Taraporevala, Rose A. Fiorenza, Seth R. Barnes, Kevin Morrill, Mark Allan C. Jacob, Carl Whitesel, Park Masterson, Grant O. Batzel, Hereroa T. Johnston, M. Desmond Ramirez, Paul S. Katz and Deirdre C. Lyons
    Citation: BMC Biology 2024 22:9
    Content type: Research article Published on:

  16. Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment.

    Authors: Tengfei Lu, Yannan Ji, Mengmeng Chang, Xiaoming Zhang, Yanhong Wang and Zhen Zou
    Citation: BMC Biology 2024 22:7
    Content type: Research article Published on:

  17. Precise gene targeting (GT) is a powerful tool for heritable precision genome engineering, enabling knock-in or replacement of the endogenous sequence via homologous recombination. We recently established a CR...

    Authors: Jing Li, Dali Kong, Yongping Ke, Wenjie Zeng and Daisuke Miki
    Citation: BMC Biology 2024 22:6
    Content type: Research article Published on:

  18. SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets agains...

    Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer and Katrin Paeschke
    Citation: BMC Biology 2024 22:5
    Content type: Research article Published on:

  19. The common carp (Cyprinus carpio) might best represent the domesticated allopolyploid animals. Although subgenome divergence which is well-known to be a key to allopolyploid domestication has been comprehensively...

    Authors: Min Wang, Xinxin Li, Chongnv Wang, Ming Zou, Jing Yang, Xiang-dong Li and Baocheng Guo
    Citation: BMC Biology 2024 22:4
    Content type: Research article Published on:

  21. Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and...

    Authors: Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson and Helen L. Fitzsimons
    Citation: BMC Biology 2024 22:2
    Content type: Research article Published on:

  22. Cell senescence is a sign of aging and plays a significant role in the pathogenesis of age-related disorders. For cell therapy, senescence may compromise the quality and efficacy of cells, posing potential saf...

    Authors: Liangge He, Mingzhu Li, Xinglie Wang, Xiaoyan Wu, Guanghui Yue, Tianfu Wang, Yan Zhou, Baiying Lei and Guangqian Zhou
    Citation: BMC Biology 2024 22:1
    Content type: Research article Published on:

  24. The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose questions on how much is currently known ab...

    Authors: Lydia Teboul, Yann Hérault, Sara Wells and Guillaume Pavlovic
    Citation: BMC Biology 2023 21:301
    Content type: Comment Published on:

  28. Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D organoid cultures in non-model animals, such as dogs....

    Authors: Karin Allenspach, Yana Zavros, Mohamed Elbadawy, Christopher Zdyrski and Jonathan Paul Mochel
    Citation: BMC Biology 2023 21:297
    Content type: Comment Published on:

  29. Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics...

    Authors: Margherita De Marzio, Kimberly Glass and Marieke L. Kuijjer
    Citation: BMC Biology 2023 21:296
    Content type: Comment Published on:

  34. Identifying the key factors that underlie complex traits during domestication is a great challenge for evolutionary and biological studies. In addition to the protein-coding region differences caused by varian...

    Authors: Zhong-Tao Yin, Xiao-Qin Li, Yun-Xiao Sun, Jacqueline Smith, Maxwell Hincke, Ning Yang and Zhuo-Cheng Hou
    Citation: BMC Biology 2023 21:303
    Content type: Research article Published on:

  36. Alzheimer’s disease (AD) is the most common neurodegenerative disorder with clinical presentations of progressive cognitive and memory deterioration. The pathologic hallmarks of AD include tau neurofibrillary ...

    Authors: Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin and Shu-Chun Teng
    Citation: BMC Biology 2023 21:293
    Content type: Research article Published on:

  37. Olfactory sensory neurons detect odourants via multiple long cilia that protrude from their dendritic endings. The G protein-coupled receptor GPRC5C was identified as part of the olfactory ciliary membrane pro...

    Authors: Sneha Bhat, André Dietz, Katja Senf, Sandor Nietzsche, Yoshio Hirabayashi, Martin Westermann and Eva Maria Neuhaus
    Citation: BMC Biology 2023 21:292
    Content type: Research article Published on:

  38. Rhabdomeric photoreceptors of eyes in the terrestrial slug Limax are the typical invertebrate-type but unique in that three visual opsins (Gq-coupled rhodopsin, xenopsin, Opn5A) and one retinochrome, all belongin...

    Authors: Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo and Akihisa Terakita
    Citation: BMC Biology 2023 21:291
    Content type: Research article Published on:

  39. Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nu...

    Authors: Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry and Mary Kathryn Sewell-Loftin
    Citation: BMC Biology 2023 21:290
    Content type: Research article Published on:

  41. Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotect...

    Authors: Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger and Adam R. Konopka
    Citation: BMC Biology 2023 21:287
    Content type: Review Published on:

  42. Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and agricultural species. Genotyping-by-sequencing, a method which uses low-coverage sequen...

    Authors: H. J. Lamb, L. T. Nguyen, J. P. Copley, B. N. Engle, B. J. Hayes and E. M. Ross
    Citation: BMC Biology 2023 21:286
    Content type: Research article Published on:

  43. Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM ...

    Authors: Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang and Ran Huo
    Citation: BMC Biology 2023 21:285
    Content type: Research article Published on:

  44. Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remain a conspicuous gap in molecular studies of marine adaptation in vertebrates.

    Authors: Alastair J. Ludington, Jillian M. Hammond, James Breen, Ira W. Deveson and Kate L. Sanders
    Citation: BMC Biology 2023 21:284
    Content type: Research article Published on:

  45. Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. These levels of organisation all exist within the same system, with diversity patterns eme...

    Authors: Thomas Keggin, Conor Waldock, Alexander Skeels, Oskar Hagen, Camille Albouy, Stéphanie Manel and Loïc Pellissier
    Citation: BMC Biology 2023 21:282
    Content type: Research article Published on:

  46. Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fg...

    Authors: Rheannon O. Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie and Patrick S. Western
    Citation: BMC Biology 2023 21:281
    Content type: Research article Published on:

  47. Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal mi...

    Authors: Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang and Weihong Jiang
    Citation: BMC Biology 2023 21:280
    Content type: Research article Published on:

  48. The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasites is rarely studied. Divalent metal transporter (DMT1) is a critical iron transporter...

    Authors: Mengjiao Zhong and Bing Zhou
    Citation: BMC Biology 2023 21:279
    Content type: Research article Published on:

  50. Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.

    Authors: Madeleine Birgersson, Rajitha Indukuri, Linnéa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer and Cecilia Williams
    Citation: BMC Biology 2023 21:277
    Content type: Research article Published on:
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