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  1. The main function of telomerase is at the telomeres but under adverse conditions telomerase can bind to internal regions causing deleterious effects as observed in cancer cells.

    Authors: Satyaprakash Pandey, Mona Hajikazemi, Theresa Zacheja, Stephanie Schalbetter, Matthew J. Neale, Jonathan Baxter, Victor Guryev, Andreas Hofmann, Dieter W. Heermann, Stefan A. Juranek and Katrin Paeschke
    Citation: BMC Biology 2021 19:247

    The Correction to this article has been published in BMC Biology 2022 20:29

  2. Cell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic a...

    Authors: Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon and Jacques Behmoaras
    Citation: BMC Biology 2021 19:246
  3. The Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and is essential for cell growth, proliferation, and differentiation. Rece...

    Authors: Yuanyuan Shi, Jian Chen, Wei-Jie Zeng, Miao Li, Wenxue Zhao, Xing-Ding Zhang and Jie Yao
    Citation: BMC Biology 2021 19:245
  4. Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set o...

    Authors: Anabella P. Trigila, Francisco Pisciottano and Lucía F. Franchini
    Citation: BMC Biology 2021 19:244
  5. Circulating miRNAs (c-miRNAs) are found in most, if not all, biological fluids and are becoming well-established non-invasive biomarkers of many human pathologies. However, their features in non-pathological c...

    Authors: Emilie Cardona, Cervin Guyomar, Thomas Desvignes, Jérôme Montfort, Samia Guendouz, John H. Postlethwait, Sandrine Skiba-Cassy and Julien Bobe
    Citation: BMC Biology 2021 19:235
  6. The radiation of ecdysozoans (moulting animals) during the Cambrian gave rise to panarthropods and various groups of worms including scalidophorans, which played an important role in the elaboration of early m...

    Authors: Deng Wang, Jean Vannier, Cédric Aria, Jie Sun and Jian Han
    Citation: BMC Biology 2021 19:243

    The Correction to this article has been published in BMC Biology 2022 20:30

  7. The rice weevil Sitophilus oryzae is one of the most important agricultural pests, causing extensive damage to cereal in fields and to stored grains. S. oryzae has an intracellular symbiotic relationship (endosym...

    Authors: Nicolas Parisot, Carlos Vargas-Chávez, Clément Goubert, Patrice Baa-Puyoulet, Séverine Balmand, Louis Beranger, Caroline Blanc, Aymeric Bonnamour, Matthieu Boulesteix, Nelly Burlet, Federica Calevro, Patrick Callaerts, Théo Chancy, Hubert Charles, Stefano Colella, André Da Silva Barbosa…
    Citation: BMC Biology 2021 19:241
  8. Oral microbiome dysbiosis is linked to overt inflammation of tooth-supporting tissues, leading to periodontitis, an oral condition that can cause tooth and bone loss. Microbiome dysbiosis has been described as...

    Authors: Ana Duran-Pinedo, Jose Solbiati, Flavia Teles, Ricardo Teles, Yanping Zang and Jorge Frias-Lopez
    Citation: BMC Biology 2021 19:240
  9. Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases,...

    Authors: Guiran Xiao, Mengran Zhao, Zhihua Liu, Fan Du and Bing Zhou
    Citation: BMC Biology 2021 19:236
  10. Shipworms are marine xylophagus bivalve molluscs, which can live on a diet solely of wood due to their ability to produce plant cell wall-degrading enzymes. Bacterial carbohydrate-active enzymes (CAZymes), syn...

    Authors: Giovanna Pesante, Federico Sabbadin, Luisa Elias, Clare Steele-King, J. Reuben Shipway, Adam A. Dowle, Yi Li, Marta Busse-Wicher, Paul Dupree, Katrin Besser, Simon M. Cragg, Neil C. Bruce and Simon J. McQueen-Mason
    Citation: BMC Biology 2021 19:233
  11. Flowering plants (angiosperms) are dominant components of global terrestrial ecosystems, but phylogenetic relationships at the familial level and above remain only partially resolved, greatly impeding our full...

    Authors: Hong-Tao Li, Yang Luo, Lu Gan, Peng-Fei Ma, Lian-Ming Gao, Jun-Bo Yang, Jie Cai, Matthew A. Gitzendanner, Peter W. Fritsch, Ting Zhang, Jian-Jun Jin, Chun-Xia Zeng, Hong Wang, Wen-Bin Yu, Rong Zhang, Michelle van der Bank…
    Citation: BMC Biology 2021 19:232
  12. The detection of environmental cues and signals via the sensory system directs behavioral choices in diverse organisms. Insect larvae rely on input from the chemosensory system, mainly olfaction, for locating ...

    Authors: Santosh V. Revadi, Vito Antonio Giannuzzi, Valeria Rossi, Gert Martin Hunger, Lucie Conchou, Gabriele Rondoni, Eric Conti, Peter Anderson, William B. Walker, Emmanuelle Jacquin-Joly, Fotini Koutroumpa and Paul G. Becher
    Citation: BMC Biology 2021 19:231
  13. Blowflies are ubiquitous insects, often shiny and metallic, and the larvae of many species provide important ecosystem services (e.g., recycling carrion) and are used in forensics and debridement therapy. Yet,...

    Authors: Liping Yan, Thomas Pape, Karen Meusemann, Sujatha Narayanan Kutty, Rudolf Meier, Keith M. Bayless and Dong Zhang
    Citation: BMC Biology 2021 19:230
  14. Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins. These proteins are generally considered to be binary co...

    Authors: Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér and Jian Zhao
    Citation: BMC Biology 2021 19:229
  15. Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane.

    Authors: Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon…
    Citation: BMC Biology 2021 19:228
  16. Female reproductive behaviors and physiology change profoundly after mating. The control of pregnancy-associated changes in physiology and behaviors are largely hard-wired into the brain to guarantee reproduct...

    Authors: Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta and Matthias Soller
    Citation: BMC Biology 2021 19:226
  17. Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that transduces extracellular signals in virtually all eukaryotic cells. The soluble Beggiatoa photoactivatable adenylyl cyclase (bPAC) rapid...

    Authors: Shang Yang, Oana M. Constantin, Divya Sachidanandan, Hannes Hofmann, Tobias C. Kunz, Vera Kozjak-Pavlovic, Thomas G. Oertner, Georg Nagel, Robert J. Kittel, Christine E. Gee and Shiqiang Gao
    Citation: BMC Biology 2021 19:227
  18. The human foetus typically needs to rotate when passing through the tight birth canal because of the complex shape of the pelvis. In most women, the upper part, or inlet, of the birth canal has a round or medi...

    Authors: Ekaterina Stansfield, Barbara Fischer, Nicole D. S. Grunstra, Maria Villa Pouca and Philipp Mitteroecker
    Citation: BMC Biology 2021 19:224
  19. The zinc-finger transcription factor Krüppel-homolog 1 (Kr-h1) exerts a dual regulatory role during insect development by preventing precocious larval/nymphal metamorphosis and in stimulating aspects of adult ...

    Authors: Zhongxia Wu, Libin Yang, Huihui Li and Shutang Zhou
    Citation: BMC Biology 2021 19:222
  20. Skin-penetrating nematodes of the genus Strongyloides infect over 600 million people, posing a major global health burden. Their life cycle includes both a parasitic and free-living generation. During the parasit...

    Authors: Ivan N. Chavez, Taylor M. Brown, Adrien Assié, Astra S. Bryant, Buck S. Samuel and Elissa A. Hallem
    Citation: BMC Biology 2021 19:221
  21. Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance...

    Authors: Saskia Pfrengle, Judith Neukamm, Meriam Guellil, Marcel Keller, Martyna Molak, Charlotte Avanzi, Alena Kushniarevich, Núria Montes, Gunnar U. Neumann, Ella Reiter, Rezeda I. Tukhbatova, Nataliya Y. Berezina, Alexandra P. Buzhilova, Dmitry S. Korobov, Stian Suppersberger Hamre, Vitor M. J. Matos…
    Citation: BMC Biology 2021 19:220
  22. Plasmodium simium, a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We sequenced the P. simium genome to investigate its evolutionary history an...

    Authors: Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzmán-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Júnior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fátima Ferreira-da-Cruz, Ricardo Lourenço de Oliveira…
    Citation: BMC Biology 2021 19:219
  23. Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis,...

    Authors: Anika V. Prabhu, Insung Kang, Raffaella De Pace, Christopher A. Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S. Ory, Juan S. Bonifacino, Michael E. Ward and Forbes D. Porter
    Citation: BMC Biology 2021 19:218
  24. DNA barcodes are a useful tool for discovering, understanding, and monitoring biodiversity which are critical tasks at a time of rapid biodiversity loss. However, widespread adoption of barcodes requires cost-...

    Authors: Amrita Srivathsan, Leshon Lee, Kazutaka Katoh, Emily Hartop, Sujatha Narayanan Kutty, Johnathan Wong, Darren Yeo and Rudolf Meier
    Citation: BMC Biology 2021 19:217
  25. Maturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and defects in synaptic maturation may contribute to neurodevelopmental disorde...

    Authors: Andonia Petkova-Tuffy, Nina Gödecke, Julio Viotti, Martin Korte and Thomas Dresbach
    Citation: BMC Biology 2021 19:215
  26. How microbes affect host fitness and environmental adaptation has become a fundamental research question in evolutionary biology. To better understand the role of microbial genomic variation for host fitness, ...

    Authors: Yun Wang, Franz Baumdicker, Paul Schweiger, Sven Kuenzel and Fabian Staubach
    Citation: BMC Biology 2021 19:187
  27. Yeast one-hybrid (Y1H) is a common technique for identifying DNA-protein interactions, and robotic platforms have been developed for high-throughput analyses to unravel the gene regulatory networks in many org...

    Authors: Ni-Chiao Tsai, Tzu-Shu Hsu, Shang-Che Kuo, Chung-Ting Kao, Tzu-Huan Hung, Da-Gin Lin, Chung-Shu Yeh, Chia-Chen Chu, Jeng-Shane Lin, Hsin-Hung Lin, Chia-Ying Ko, Tien-Hsien Chang, Jung-Chen Su and Ying-Chung Jimmy Lin
    Citation: BMC Biology 2021 19:214
  28. Activation of gene expression in striped domains is a key building block of biological patterning, from the recursive formation of veins in plant leaves to that of ribs and vertebrae in our bodies. In animals,...

    Authors: Anmol Krishna, Jason Gardiner, Tyler J. Donner and Enrico Scarpella
    Citation: BMC Biology 2021 19:213
  29. Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is ofte...

    Authors: Elizabeth Oliver, João Pedro Alves-Lopes, Femke Harteveld, Rod T. Mitchell, Elisabet Åkesson, Olle Söder and Jan-Bernd Stukenborg
    Citation: BMC Biology 2021 19:212
  30. Glossina species (tsetse flies), the sole vectors of African trypanosomes, maintained along their long evolutionary history a unique reproductive strategy, adenotrophic viviparity. Viviparity reduces their reprod...

    Authors: Grazia Savini, Francesca Scolari, Lino Ometto, Omar Rota-Stabelli, Davide Carraretto, Ludvik M. Gomulski, Giuliano Gasperi, Adly M. M. Abd-Alla, Serap Aksoy, Geoffrey M. Attardo and Anna R. Malacrida
    Citation: BMC Biology 2021 19:211
  31. Species co-occurrences can have profound effects on the habitat use of species, and therefore habitat structure alone cannot fully explain observed abundances. To account for this aspect of community organizat...

    Authors: Marco Basile, Thomas Asbeck, João M. Cordeiro Pereira, Grzegorz Mikusiński and Ilse Storch
    Citation: BMC Biology 2021 19:210
  32. Authors: Sarah Farhat, Phuong Le, Ehsan Kayal, Benjamin Noel, Estelle Bigeard, Erwan Corre, Florian Maumus, Isabelle Florent, Adriana Alberti, Jean-Marc Aury, Tristan Barbeyron, Ruibo Cai, Corinne Da Silva, Benjamin Istace, Karine Labadie, Dominique Marie…
    Citation: BMC Biology 2021 19:209

    The original article was published in BMC Biology 2021 19:1

  33. Variability is a hallmark of animal behavior. It contributes to survival by endowing individuals and populations with the capacity to adapt to ever-changing environmental conditions. Intra-individual variabili...

    Authors: Guillaume Le Goc, Julie Lafaye, Sophia Karpenko, Volker Bormuth, Raphaël Candelier and Georges Debrégeas
    Citation: BMC Biology 2021 19:208
  34. Intra-tumor heterogeneity (ITH) encompasses cellular differences in tumors and is related to clinical outcomes such as drug resistance. However, little is known about the dynamics of ITH, owing to the lack of ...

    Authors: Hanako Ono, Yasuhito Arai, Eisaku Furukawa, Daichi Narushima, Tetsuya Matsuura, Hiromi Nakamura, Daisuke Shiokawa, Momoko Nagai, Toshio Imai, Koshi Mimori, Koji Okamoto, Yoshitaka Hippo, Tatsuhiro Shibata and Mamoru Kato
    Citation: BMC Biology 2021 19:207
  35. Eukaryotic genomes are known to display an enormous variation in size, but the evolutionary causes of this phenomenon are still poorly understood. To obtain mechanistic insights into such variation, previous s...

    Authors: C. P. Stelzer, J. Blommaert, A. M. Waldvogel, M. Pichler, B. Hecox-Lea and D. B. Mark Welch
    Citation: BMC Biology 2021 19:206
  36. Pineal-related organs in cyclostomes, teleosts, amphibians, and reptiles exhibit color opponency, generating antagonistic neural responses to different wavelengths of light and thereby sensory information abou...

    Authors: Seiji Wada, Emi Kawano-Yamashita, Tomohiro Sugihara, Satoshi Tamotsu, Mitsumasa Koyanagi and Akihisa Terakita
    Citation: BMC Biology 2021 19:188
  37. The cuticular microbiomes of Acromyrmex leaf-cutting ants pose a conundrum in microbiome biology because they are freely colonisable, and yet the prevalence of the vertically transmitted bacteria Pseudonocardia, ...

    Authors: Sarah F. Worsley, Tabitha M. Innocent, Neil A. Holmes, Mahmoud M. Al-Bassam, Morten Schiøtt, Barrie Wilkinson, J. Colin Murrell, Jacobus J. Boomsma, Douglas W. Yu and Matthew I. Hutchings
    Citation: BMC Biology 2021 19:205
  38. Murray’s Law, which describes the branching architecture of bifurcating tubes, predicts the morphology of vessels in many amniotes and plants. Here, we use insects to explore the universality of Murray’s Law a...

    Authors: Sandra R. Schachat, C. Kevin Boyce, Jonathan L. Payne and David Lentink
    Citation: BMC Biology 2021 19:204
  39. Silencing of transposable elements (TEs) is essential for maintaining genome stability. Plants use small RNAs (sRNAs) to direct DNA methylation to TEs (RNA-directed DNA methylation; RdDM). Similar mechanisms o...

    Authors: Jana Sperschneider, Ashley W. Jones, Jamila Nasim, Bo Xu, Silke Jacques, Chengcheng Zhong, Narayana M. Upadhyaya, Rohit Mago, Yiheng Hu, Melania Figueroa, Karam B. Singh, Eric A. Stone, Benjamin Schwessinger, Ming-Bo Wang, Jennifer M. Taylor and Peter N. Dodds
    Citation: BMC Biology 2021 19:203
  40. The world’s fast disappearing mangrove forests have low plant diversity and are often assumed to also have a species-poor insect fauna. We here compare the tropical arthropod fauna across a freshwater swamp an...

    Authors: Darren Yeo, Amrita Srivathsan, Jayanthi Puniamoorthy, Foo Maosheng, Patrick Grootaert, Lena Chan, Benoit Guénard, Claas Damken, Rodzay A. Wahab, Ang Yuchen and Rudolf Meier
    Citation: BMC Biology 2021 19:202
  41. Gravity plays an important role in most life forms on Earth. Yet, a complete molecular understanding of sensing and responding to gravity is lacking. While there are anatomical differences among animals, there...

    Authors: Wei-Long Chen, Hungtang Ko, Han-Sheng Chuang, David M. Raizen and Haim H. Bau
    Citation: BMC Biology 2021 19:186
  42. Hematopoietic stem and progenitor cell (HSPC) subsets in mice have previously been studied using cell surface markers, and more recently single-cell technologies. The recent revolution of single-cell analysis ...

    Authors: Jinheng Wang, Chenggong Tu, Hui Zhang, Yongliang Huo, Eline Menu and Jinbao Liu
    Citation: BMC Biology 2021 19:201