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  1. Content type: Research article

    Trimeric intracellular cation (TRIC) channels are crucial for Ca2+ handling in eukaryotes and are involved in K+ uptake in prokaryotes. Recent studies on the representative members of eukaryotic and prokaryotic T...

    Authors: Xiaomin Ou, Jianli Guo, Longfei Wang, Hanting Yang, Xiuying Liu, Jianyuan Sun and Zhenfeng Liu

    Citation: BMC Biology 2017 15:31

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  2. Content type: Research article

    Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedent...

    Authors: Ricardo Laranjeiro, Girish Harinath, Daniel Burke, Bart P. Braeckman and Monica Driscoll

    Citation: BMC Biology 2017 15:30

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  3. Content type: Methodology article

    Animals exhibit astonishingly complex behaviors. Studying the subtle features of these behaviors requires quantitative, high-throughput, and accurate systems that can cope with the often rich perplexing data.

    Authors: Eyal Itskovits, Amir Levine, Ehud Cohen and Alon Zaslaver

    Citation: BMC Biology 2017 15:29

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  4. Content type: Research article

    Most agronomic traits in rice are complex and polygenic. The identification of quantitative trait loci (QTL) for grain length is an important objective of rice genetic research and breeding programs.

    Authors: Jianping Yu, Haiyan Xiong, Xiaoyang Zhu, Hongliang Zhang, Huihui Li, Jinli Miao, Wensheng Wang, Zuoshun Tang, Zhanying Zhang, Guoxin Yao, Qiang Zhang, Yinghua Pan, Xin Wang, M. A. R. Rashid, Jinjie Li, Yongming Gao…

    Citation: BMC Biology 2017 15:28

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  5. Content type: Research article

    Mitochondria of opisthokonts undergo permanent fission and fusion throughout the cell cycle. Here, we investigated the dynamics of the mitosomes, the simplest forms of mitochondria, in the anaerobic protist pa...

    Authors: Luboš Voleman, Vladimíra Najdrová, Ásgeir Ástvaldsson, Pavla Tůmová, Elin Einarsson, Zdeněk Švindrych, Guy M. Hagen, Jan Tachezy, Staffan G. Svärd and Pavel Doležal

    Citation: BMC Biology 2017 15:27

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  6. Content type: Methodology article

    Contamination is a well-known but often neglected problem in molecular biology. Here, we investigated the prevalence of cross-contamination among 446 samples from 116 distinct species of animals, which were pr...

    Authors: Marion Ballenghien, Nicolas Faivre and Nicolas Galtier

    Citation: BMC Biology 2017 15:25

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  7. Content type: Research article

    The fate of hydrogen peroxide (H2O2) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the consequences of their gen...

    Authors: Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F. Kaminski, David Ron and Edward Avezov

    Citation: BMC Biology 2017 15:24

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  8. Content type: Question and Answer

    Salicylic acid (SA) is an important plant hormone that regulates many aspects of plant growth and development, as well as resistance to (a)biotic stress. Efforts to identify SA effector proteins have revealed ...

    Authors: D’Maris Amick Dempsey and Daniel F. Klessig

    Citation: BMC Biology 2017 15:23

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  9. Content type: Methodology article

    In addition to messenger RNA (mRNA), noncoding RNAs (ncRNAs) are essential components in cellular machineries for translation and splicing. Besides their housekeeping functions, ncRNAs are involved in cell typ...

    Authors: Yi-Hsuan Lee, Ya-Wen Hsueh, Yao-Hung Peng, Kung-Chao Chang, Kuen-Jer Tsai, H. Sunny Sun, Ih-Jen Su and Po-Min Chiang

    Citation: BMC Biology 2017 15:22

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  10. Content type: Research article

    Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the d...

    Authors: Estefania Tarifeño-Saldivia, Arnaud Lavergne, Alice Bernard, Keerthana Padamata, David Bergemann, Marianne L. Voz, Isabelle Manfroid and Bernard Peers

    Citation: BMC Biology 2017 15:21

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  11. Content type: Research article

    Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent col...

    Authors: David C. Prince, Ghanasyam Rallapalli, Deyang Xu, Henk-jan Schoonbeek, Volkan Çevik, Shuta Asai, Eric Kemen, Neftaly Cruz-Mireles, Ariane Kemen, Khaoula Belhaj, Sebastian Schornack, Sophien Kamoun, Eric B. Holub, Barbara A. Halkier and Jonathan D. G. Jones

    Citation: BMC Biology 2017 15:20

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  12. Content type: Research article

    Understanding the patterns of biodiversity distribution and what influences them is a fundamental pre-requisite for effective conservation and sustainable utilisation of biodiversity. Such knowledge is increas...

    Authors: Marc S. M. Sosef, Gilles Dauby, Anne Blach-Overgaard, Xander van der Burgt, Luís Catarino, Theo Damen, Vincent Deblauwe, Steven Dessein, John Dransfield, Vincent Droissart, Maria Cristina Duarte, Henry Engledow, Geoffrey Fadeur, Rui Figueira, Roy E. Gereau, Olivier J. Hardy…

    Citation: BMC Biology 2017 15:15

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  13. Content type: Research article

    Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and di...

    Authors: Ryan G. Walker, Magdalena Czepnik, Erich J. Goebel, Jason C. McCoy, Ana Vujic, Miook Cho, Juhyun Oh, Senem Aykul, Kelly L. Walton, Gauthier Schang, Daniel J. Bernard, Andrew P. Hinck, Craig A. Harrison, Erik Martinez-Hackert, Amy J. Wagers, Richard T. Lee…

    Citation: BMC Biology 2017 15:19

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  14. Content type: Research article

    The mosquito Aedes aegypti is the main vector of dengue, Zika, chikungunya and yellow fever viruses. This major disease vector is thought to have arisen when the African subspecies Ae. aegypti formosus evolved fr...

    Authors: Jacob E. Crawford, Joel M. Alves, William J. Palmer, Jonathan P. Day, Massamba Sylla, Ranjan Ramasamy, Sinnathamby N. Surendran, William C. Black IV, Arnab Pain and Francis M. Jiggins

    Citation: BMC Biology 2017 15:16

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  15. Content type: Software

    The determination and regulation of cell morphology are critical components of cell-cycle control, fitness, and development in both single-cell and multicellular organisms. Understanding how environmental fact...

    Authors: Tristan Ursell, Timothy K. Lee, Daisuke Shiomi, Handuo Shi, Carolina Tropini, Russell D. Monds, Alexandre Colavin, Gabriel Billings, Ilina Bhaya-Grossman, Michael Broxton, Bevan Emma Huang, Hironori Niki and Kerwyn Casey Huang

    Citation: BMC Biology 2017 15:17

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  16. Content type: Research article

    Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation...

    Authors: Silke Kiessling, Lou Beaulieu-Laroche, Ian D. Blum, Dominic Landgraf, David K. Welsh, Kai-Florian Storch, Nathalie Labrecque and Nicolas Cermakian

    Citation: BMC Biology 2017 15:13

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  17. Content type: Research article

    Flies have some of the most elaborate visual systems in the Insecta, often featuring large, sexually dimorphic eyes with specialized “bright zones” that may have a functional role during mate-seeking behavior....

    Authors: Courtney Eichorn, Michael Hrabar, Emma C. Van Ryn, Bekka S. Brodie, Adam J. Blake and Gerhard Gries

    Citation: BMC Biology 2017 15:2

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  18. Content type: Research article

    Cyanobacteria are important agents in global carbon and nitrogen cycling and hold great promise for biotechnological applications. Model organisms such as Synechocystis sp. and Synechococcus sp. have advanced our...

    Authors: Feiqiao Brian Yu, Lisa Willis, Rosanna Man Wah Chau, Alessandro Zambon, Mark Horowitz, Devaki Bhaya, Kerwyn Casey Huang and Stephen R. Quake

    Citation: BMC Biology 2017 15:11

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  19. Content type: Research article

    Departures from the standard genetic code in eukaryotic nuclear genomes are known for only a handful of lineages and only a few genetic code variants seem to exist outside the ciliates, the most creative group...

    Authors: Tomáš Pánek, David Žihala, Martin Sokol, Romain Derelle, Vladimír Klimeš, Miluše Hradilová, Eliška Zadrobílková, Edward Susko, Andrew J. Roger, Ivan Čepička and Marek Eliáš

    Citation: BMC Biology 2017 15:8

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  20. Content type: Research article

    Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic ca...

    Authors: Jing Wang, Kumar Nikhil, Keith Viccaro, Lei Chang, Jacoba White and Kavita Shah

    Citation: BMC Biology 2017 15:10

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  21. Content type: Research article

    A widespread modulation of gene expression occurs in the aging brain, but little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine regulators of gene expression in many biological...

    Authors: Roberto Ripa, Luca Dolfi, Marco Terrigno, Luca Pandolfini, Aurora Savino, Valeria Arcucci, Marco Groth, Eva Terzibasi Tozzini, Mario Baumgart and Alessandro Cellerino

    Citation: BMC Biology 2017 15:9

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  22. Content type: Research article

    Animals use sensory cues to efficiently locate resources, but when sensory information is insufficient, they may rely on internally coded search strategies. Despite the importance of search behavior, there is ...

    Authors: Eric J. Horstick, Yared Bayleyen, Jennifer L. Sinclair and Harold A. Burgess

    Citation: BMC Biology 2017 15:4

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  23. Content type: Research article

    Aggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corr...

    Authors: Nicole Beuret, Franziska Hasler, Cristina Prescianotto-Baschong, Julia Birk, Jonas Rutishauser and Martin Spiess

    Citation: BMC Biology 2017 15:5

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  24. Content type: Research article

    Apicomplexan parasites employ a unique form of movement, termed gliding motility, in order to invade the host cell. This movement depends on the parasite’s actomyosin system, which is thought to generate the f...

    Authors: Jamie A. Whitelaw, Fernanda Latorre-Barragan, Simon Gras, Gurman S. Pall, Jacqueline M. Leung, Aoife Heaslip, Saskia Egarter, Nicole Andenmatten, Shane R. Nelson, David M. Warshaw, Gary E. Ward and Markus Meissner

    Citation: BMC Biology 2017 15:1

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  25. Content type: Research article

    Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evoluti...

    Authors: Irina Maljkovic Berry, Melanie C. Melendrez, Tao Li, Anthony W. Hawksworth, Gary T. Brice, Patrick J. Blair, Eric S. Halsey, Maya Williams, Stefan Fernandez, In-Kyu Yoon, Leslie D. Edwards, Robert Kuschner, Xiaoxu Lin, Stephen J. Thomas and Richard G. Jarman

    Citation: BMC Biology 2016 14:117

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  26. Content type: Comment

    Western blotting is among the most common techniques used in molecular biology and a simple way of assessing the presence or absence of a protein. It is also commonly used to compare protein levels in differen...

    Authors: Graham Bell

    Citation: BMC Biology 2016 14:116

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  27. Content type: Review

    Probing dynamic processes occurring within the cell nucleus at the quantitative level has long been a challenge in mammalian biology. Advances in bio-imaging techniques over the past decade have enabled us to ...

    Authors: Ziqing W. Zhao, Melanie D. White, Stephanie Bissiere, Valeria Levi and Nicolas Plachta

    Citation: BMC Biology 2016 14:115

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  28. Content type: Research article

    Polycomb repressive complex 2 (PRC2)-catalyzed H3K27me3 marks are tightly associated with the WUS-AG negative feedback loop to terminate floral stem cell fate to promote carpel development, but the roles of Polyc...

    Authors: Donghong Chen, Anne M. Molitor, Lin Xu and Wen-Hui Shen

    Citation: BMC Biology 2016 14:112

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  29. Content type: Question and Answer

    Brassinosteroids (BRs) are a class of polyhydroxylated steroidal phytohormones in plants with similar structures to animals’ steroid hormones. Brassinosteroids regulate a wide range of physiological processes ...

    Authors: Jiao Tang, Zhifu Han and Jijie Chai

    Citation: BMC Biology 2016 14:113

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  30. Content type: Research article

    The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and p...

    Authors: Wenbo Chen, Daniel K. Hasegawa, Navneet Kaur, Adi Kliot, Patricia Valle Pinheiro, Junbo Luan, Marcus C. Stensmyr, Yi Zheng, Wenli Liu, Honghe Sun, Yimin Xu, Yuan Luo, Angela Kruse, Xiaowei Yang, Svetlana Kontsedalov, Galina Lebedev…

    Citation: BMC Biology 2016 14:110

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  31. Content type: Research article

    Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, whic...

    Authors: Deborah L. McEwan, Rhonda L. Feinbaum, Nicholas Stroustrup, Wilhelm Haas, Annie L. Conery, Anthony Anselmo, Ruslan Sadreyev and Frederick M. Ausubel

    Citation: BMC Biology 2016 14:105

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  32. Content type: Research article

    Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic challenges. mFAO enzymes accept multiple substrates of different chain length, leadi...

    Authors: Karen van Eunen, Catharina M. L. Volker-Touw, Albert Gerding, Aycha Bleeker, Justina C. Wolters, Willemijn J. van Rijt, Anne-Claire M. F. Martines, Klary E. Niezen-Koning, Rebecca M. Heiner, Hjalmar Permentier, Albert K. Groen, Dirk-Jan Reijngoud, Terry G. J. Derks and Barbara M. Bakker

    Citation: BMC Biology 2016 14:107

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  33. Content type: Research article

    Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number o...

    Authors: Kyung Won Kim, Nishant Thakur, Christopher A. Piggott, Shizue Omi, Jolanta Polanowska, Yishi Jin and Nathalie Pujol

    Citation: BMC Biology 2016 14:104

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  34. Content type: Research article

    Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have be...

    Authors: Shaun S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A. Raymond and Michael R. Hayden

    Citation: BMC Biology 2016 14:108

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  35. Content type: Research article

    Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa pr...

    Authors: Anita K. Ho, Jane L. Wagstaff, Paul T. Manna, Lena Wartosch, Seema Qamar, Elspeth F. Garman, Stefan M. V. Freund and Rhys C. Roberts

    Citation: BMC Biology 2016 14:109

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  36. Content type: Research article

    Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role th...

    Authors: Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas and Antonis Kirmizis

    Citation: BMC Biology 2016 14:106

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  37. Content type: Research article

    The specificity of synaptic connections is fundamental for proper neural circuit function. Specific neuronal connections that underlie information processing in the sensory cortex are initially established wit...

    Authors: Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda, Toshihiro Kobayashi, Megumi Kato-Itoh, Hiromitsu Nakauchi, Masumi Hirabayashi, Takeshi Yagi and Yumiko Yoshimura

    Citation: BMC Biology 2016 14:103

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