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  1. The callipyge mutation is located within an imprinted gene cluster on ovine chromosome 18. The callipyge trait exhibits polar overdominant inheritance due to the fact that only heterozygotes inheriting a mutan...

    Authors: Christopher A Bidwell, Lauren N Kramer, Allison C Perkins, Tracy S Hadfield, Diane E Moody and Noelle E Cockett
    Citation: BMC Biology 2004 2:17
    Content type: Research article Published on:

  3. The growing conviction that lateral gene transfer plays a significant role in prokaryote genealogy opens up a need for comprehensive evaluations of gene-enzyme systems on a case-by-case basis. Genes of tryptop...

    Authors: Gary Xie, Carol A Bonner, Jian Song, Nemat O Keyhani and Roy A Jensen
    Citation: BMC Biology 2004 2:15
    Content type: Research article Published on:

  6. The observation of multiple genetic markers in situ by optical microscopy and their relevance to the study of three-dimensional (3D) chromosomal organization in the nucleus have been greatly developed in the last...

    Authors: Tony Chih Yuan Chuang, Sharareh Moshir, Yuval Garini, Alice Ya-Chun Chuang, Ian T Young, Bart Vermolen, Richard van den Doel, Virginie Mougey, Mathilde Perrin, Martina Braun, Paul Donald Kerr, Thierry Fest, Petra Boukamp and Sabine Mai
    Citation: BMC Biology 2004 2:12
    Content type: Research article Published on:

  7. DNA polymerase ε (Pol ε) is essential for S-phase replication, DNA damage repair and checkpoint control in yeast. A pol2-Y831A mutation leading to a tyrosine to alanine change in the Pol ε active site does not ca...

    Authors: Youri I Pavlov, Satoko Maki, Hisaji Maki and Thomas A Kunkel
    Citation: BMC Biology 2004 2:11
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Biology 2007 5:27

  10. The 5' end of the Rous sarcoma virus (RSV) RNA around the primer-binding site forms a series of RNA secondary stem/loop structures (U5-IR stem, TψC interaction region, U5-leader stem) that are required for eff...

    Authors: Michael Johnson, Shannon Morris, Aiping Chen, Ed Stavnezer and Jonathan Leis
    Citation: BMC Biology 2004 2:8
    Content type: Research article Published on:

  12. Runx transcription factors are important regulators of metazoan development. The sea urchin Runx gene SpRunt was previously identified as a trans-activator of the CyIIIa actin gene, a differentiation marker of la...

    Authors: James A Coffman, Carrie Dickey-Sims, Jeffrey S Haug, John J McCarthy and Anthony J Robertson
    Citation: BMC Biology 2004 2:6
    Content type: Research article Published on:

  13. Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis. The growth suppressor p27kip1 associates with several cyclin-d...

    Authors: Pelayo González, Antonio Díez-Juan, Eliecer Coto, Victoria Álvarez, Julian R Reguero, Alberto Batalla and Vicente Andrés
    Citation: BMC Biology 2004 2:5
    Content type: Research article Published on:

  14. The bacterial ribosome is a primary target of several classes of antibiotics. Investigation of the structure of the ribosomal subunits in complex with different antibiotics can reveal the mode of inhibition of...

    Authors: Jörg M Harms, Frank Schlünzen, Paola Fucini, Heike Bartels and Ada Yonath
    Citation: BMC Biology 2004 2:4
    Content type: Research article Published on:

  15. Phylogenetic analyses of jawed vertebrates based on mitochondrial sequences often result in confusing inferences which are obviously inconsistent with generally accepted trees. In particular, in a hypothesis b...

    Authors: Kanae Kikugawa, Kazutaka Katoh, Shigehiro Kuraku, Hiroshi Sakurai, Osamu Ishida, Naoyuki Iwabe and Takashi Miyata
    Citation: BMC Biology 2004 2:3
    Content type: Research article Published on:

  16. Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopept...

    Authors: Rachell E Booth, Simon C Lovell, Stephanie A Misquitta and Robert C Bateman Jr
    Citation: BMC Biology 2004 2:2
    Content type: Research article Published on:

  17. The earliest fossil evidence of terrestrial animal activity is from the Ordovician, ~450 million years ago (Ma). However, there are earlier animal fossils, and most molecular clocks suggest a deep origin of an...

    Authors: Davide Pisani, Laura L Poling, Maureen Lyons-Weiler and S Blair Hedges
    Citation: BMC Biology 2004 2:1
    Content type: Research article Published on:

  18. RNA silencing processes are widespread in almost all eukaryotic organisms. They have various functions including genome protection, and the control of gene expression, development and heterochromatin formation...

    Authors: Mickaël Durand-Dubief and Philippe Bastin
    Citation: BMC Biology 2003 1:2
    Content type: Research article Published on:

  19. The assessment of data reproducibility is essential for application of microarray technology to exploration of biological pathways and disease states. Technical variability in data analysis largely depends on ...

    Authors: Vikram Budhraja, Edward Spitznagel, W Timothy Schaiff and Yoel Sadovsky
    Citation: BMC Biology 2003 1:1
    Content type: Research article Published on:
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