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Articles
Page 48 of 55
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Citation: BMC Biology 2010 8:77
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The (r)evolution of cancer genetics
The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards pertu...
Citation: BMC Biology 2010 8:74 -
Erratum to: Exploiting the promiscuity of imatinib
Citation: BMC Biology 2010 8:82 -
A new strategy for isolating genes controlling dosage compensation in Drosophilausing a simple epigenetic mosaic eye phenotype
The Drosophila Male Specific Lethal (MSL) complex contains chromatin modifying enzymes and non-coding roX RNA. It paints the male X at hundreds of bands where it acetylates histone H4 at lysine 16. This epigeneti...
Citation: BMC Biology 2010 8:80 -
Plastid evolution: gene transfer and the maintenance of 'stolen' organelles
Many heterotrophic organisms sequester plastids from prey algae and temporarily utilize their photosynthetic capacity. A recent article in BMC Genomics reveals that the dinoflagellate Dinophysis acuminata has acq...
Citation: BMC Biology 2010 8:73 -
Caenorhabditis elegansbehavioral genetics: where are the knobs?
Thousands of behavioral mutants of Caenorhabditis elegans have been studied. I suggest a set of criteria by which some genes important in the evolution of behavior might be recognized, and identify neuropeptide s...
Citation: BMC Biology 2010 8:69 -
A rapid and scalable method for selecting recombinant mouse monoclonal antibodies
Monoclonal antibodies with high affinity and selectivity that work on wholemount fixed tissues are valuable reagents to the cell and developmental biologist, and yet isolating them remains a long and unpredict...
Citation: BMC Biology 2010 8:76 -
Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odour...
Citation: BMC Biology 2010 8:75 -
On the scent of sexual attraction
A study in the current issue of BMC Biology has identified a mouse major urinary protein as a pheromone that attracts female mice to male urine marks and induces a learned attraction to the volatile urinary odor ...
Citation: BMC Biology 2010 8:71 -
Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
Spartin protein is involved in degradation of epidermal growth factor receptor and turnover of lipid droplets and a lack of expression of this protein is responsible for hereditary spastic paraplegia type 20 (...
Citation: BMC Biology 2010 8:72 -
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family
A new family of natural products has been described in which cysteine, serine and threonine from ribosomally-produced peptides are converted to thiazoles, oxazoles and methyloxazoles, respectively. These metab...
Citation: BMC Biology 2010 8:70 -
Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis
Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is ...
Citation: BMC Biology 2010 8:63 -
Nutrient control of eukaryote cell growth: a systems biology study in yeast
To elucidate the biological processes affected by changes in growth rate and nutrient availability, we have performed a comprehensive analysis of the transcriptome, proteome and metabolome responses of chemost...
Citation: BMC Biology 2010 8:68 -
Repetitive elements in parasitic protozoa
A recent paper published in BMC Genomics suggests that retrotransposition may be active in the human gut parasite Entamoeba histolytica. This adds to our knowledge of the various types of repetitive elements in p...
Citation: BMC Biology 2010 8:64 -
Systems-biology dissection of eukaryotic cell growth
A recent article in BMC Biology illustrates the use of a systems-biology approach to integrate data across the transcriptome, proteome and metabolome of budding yeast in order to dissect the relationship between ...
Citation: BMC Biology 2010 8:62 -
Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa
Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is base...
Citation: BMC Biology 2010 8:66 -
When failure should be the option
Citation: BMC Biology 2010 8:61 -
Smart biomaterials - regulating cell behavior through signaling molecules
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. Following the recent work...
Citation: BMC Biology 2010 8:59 -
Q&A: ChIP-seq technologies and the study of gene regulation
Citation: BMC Biology 2010 8:56 -
Rapid sympatric ecological differentiation of crater lake cichlid fishes within historic times
After a volcano erupts, a lake may form in the cooled crater and become an isolated aquatic ecosystem. This makes fishes in crater lakes informative for understanding sympatric evolution and ecological diversi...
Citation: BMC Biology 2010 8:60 -
Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
Ultra-high throughput sequencing technologies provide opportunities both for discovery of novel molecular species and for detailed comparisons of gene expression patterns. Small RNA populations are particularl...
Citation: BMC Biology 2010 8:58 -
Hidden reach of the micromanagers
Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-li...
Citation: BMC Biology 2010 8:53 -
Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro
The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineeri...
Citation: BMC Biology 2010 8:57 -
A modern circadian clock in the common angiosperm ancestor of monocots and eudicots
The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analys...
Citation: BMC Biology 2010 8:55 -
Stepwise mechanism for transcription fidelity
Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complement...
Citation: BMC Biology 2010 8:54 -
Transcriptomics and disease vector control
Next-generation sequencing can be used to compare transcriptomes under different conditions. A study in BMC Genomics applies this approach to investigating the effects of exposure to a range of xenobiotics on cha...
Citation: BMC Biology 2010 8:52 -
Ecological genomics: steps towards unraveling the genetic basis of inducible defenses in Daphnia
Little is known about the genetic mechanisms underlying inducible defenses. Recently, the genome of Daphnia pulex, a model organism for defense studies, has been sequenced. Building on the genome information, rec...
Citation: BMC Biology 2010 8:51 -
Unraveling bovin phylogeny: accomplishments and challenges
The phylogenetic systematics of bovin species forms a common basis for studies at multiple scales, from the level of domestication in populations to major cladogenesis. The main big-picture accomplishments of ...
Citation: BMC Biology 2010 8:50 -
Network integration meets network dynamics
Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent pa...
Citation: BMC Biology 2010 8:48 -
A central role for p38 MAPK in the early transcriptional response to stress
The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstr...
Citation: BMC Biology 2010 8:47 -
MochiView: versatile software for genome browsing and DNA motif analysis
As high-throughput technologies rapidly generate genome-scale data, it becomes increasingly important to visually integrate these data so that specific hypotheses can be formulated and tested.
Citation: BMC Biology 2010 8:49 -
Diversity lost: are all Holarctic large mammal species just relict populations?
Population genetic analyses of Eurasian wolves published recently in BMC Evolutionary Biology suggest that a major genetic turnover took place in Eurasian wolves after the Pleistocene. These results add to the gr...
Citation: BMC Biology 2010 8:46 -
Hybridization and speciation in angiosperms: a role for pollinator shifts?
The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, ho...
Citation: BMC Biology 2010 8:45 -
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway. Whether or not this dependence on the primary cilium is a universal f...
Citation: BMC Biology 2010 8:65 -
Plus ça change
Citation: BMC Biology 2010 8:44 -
When bigger is better
Citation: BMC Biology 2010 8:43 -
Video Q&A: What is autism? - A personal view
Citation: BMC Biology 2010 8:42 -
Q&A: Promise and pitfalls of genome-wide association studies
Citation: BMC Biology 2010 8:41 -
The edges of understanding
A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was...
Citation: BMC Biology 2010 8:40 -
The hope of progress
Citation: BMC Biology 2010 8:39 -
Biology-driven cancer drug development: back to the future
Most of the significant recent advances in cancer treatment have been based on the great strides that have been made in our understanding of the underlying biology of the disease. Nevertheless, the exploitatio...
Citation: BMC Biology 2010 8:38 -
Immune mechanisms of protection: can adjuvants rise to the challenge?
For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such pathogens.
Citation: BMC Biology 2010 8:37 -
Localized direction selective responses in the dendrites of visual interneurons of the fly
The various tasks of visual systems, including course control, collision avoidance and the detection of small objects, require at the neuronal level the dendritic integration and subsequent processing of many ...
Citation: BMC Biology 2010 8:36 -
Quality prevails over identity in the sexually selected vocalisations of an ageing mammal
Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phe...
Citation: BMC Biology 2010 8:35 -
Adherens junctions remain dynamic
One of the four principal categories of cell-cell junctions that hold together and shape distinct tissues and organs in vertebrates, adherens junctions (AJs) form cell-cell contacts that connect transmembrane ...
Citation: BMC Biology 2010 8:34 -
The lethal giant larvaetumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy
Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in...
Citation: BMC Biology 2010 8:33 -
Anaerobic animals from an ancient, anoxic ecological niche
Tiny marine animals that complete their life cycle in the total absence of light and oxygen are reported by Roberto Danovaro and colleagues in this issue of BMC Biology. These fascinating animals are new members ...
Citation: BMC Biology 2010 8:32 -
Anaerobic Metazoans: No longer an oxymoron
The sediments of a deep-sea hypersaline and sulfidic Mediterranean basin have yielded an unexpected discovery, the first multicellular animals living entirely without oxygen. Reported by Danovaro et al. in BMC Bi...
Citation: BMC Biology 2010 8:31 -
The first metazoa living in permanently anoxic conditions
Several unicellular organisms (prokaryotes and protozoa) can live under permanently anoxic conditions. Although a few metazoans can survive temporarily in the absence of oxygen, it is believed that multi-cellu...
Citation: BMC Biology 2010 8:30 -
The zebra finch neuropeptidome: prediction, detection and expression
Among songbirds, the zebra finch (Taeniopygia guttata) is an excellent model system for investigating the neural mechanisms underlying complex behaviours such as vocal communication, learning and social interacti...
Citation: BMC Biology 2010 8:28
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