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  1. Identification of potential drug-target interactions (DTIs) with high accuracy is a key step in drug discovery and repositioning, especially concerning specific drug targets. Traditional experimental methods f...

    Authors: Yongdi Zhu, Chunhui Ning, Naiqian Zhang, Mingyi Wang and Yusen Zhang
    Citation: BMC Biology 2024 22:156
    Content type: Research article Published on:

  3. Mounting evidence shows that tumor-derived extracellular vesicles (EVs) are critical constituents in the tumor microenvironment. The composition and function of EVs often change during cancer progression. Howe...

    Authors: Shenqing Sun, Qian Li, Ganggang Liu, Xiaoheng Huang, Aiqing Li, Haoran Guo, Lijuan Qi, Jie Zhang, Jianrui Song, Xiong Su and Yanling Zhang
    Citation: BMC Biology 2024 22:154
    Content type: Research article Published on:

  4. Pre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it ...

    Authors: Yanke Jiang, Yingzhe Yue, Chongchong Lu, Muhammad Zunair Latif, Haifeng Liu, Zhaoxu Wang, Ziyi Yin, Yang Li and Xinhua Ding
    Citation: BMC Biology 2024 22:153
    Content type: Research article Published on:

  5. Metabolite-associated cell communications play critical roles in maintaining human biological function. However, most existing tools and resources focus only on ligand-receptor interaction pairs where both par...

    Authors: Yuncong Zhang, Yu Yang, Liping Ren, Meixiao Zhan, Taoping Sun, Quan Zou and Yang Zhang
    Citation: BMC Biology 2024 22:152
    Content type: Research article Published on:

  6. RNA–DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination (CSR). However, the underlying phenomenon regulating the two contrasting ...

    Authors: Muzaffer Ahmad Kassab, Yibin Chen, Xin Wang, Bo He, Eric J. Brown and Xiaochun Yu
    Citation: BMC Biology 2024 22:151
    Content type: Research article Published on:

  7. Accurate detection of pheromones is crucial for chemical communication and reproduction in insects. In holometabolous flies and moths, the sensory neuron membrane protein 1 (SNMP1) is essential for detecting l...

    Authors: Joris Lehmann, Yannick Günzel, Maryam Khosravian, Sina Cassau, Susanne Kraus, Johanna S. Libnow, Hetan Chang, Bill S. Hansson, Heinz Breer, Einat Couzin-Fuchs, Joerg Fleischer and Jürgen Krieger
    Citation: BMC Biology 2024 22:150
    Content type: Research article Published on:

  8. Organisms frequently experience environmental stresses that occur in predictable patterns and combinations. For wild Saccharomyces cerevisiae yeast growing in natural environments, cells may experience high osmot...

    Authors: Amanda N. Scholes, Tara N. Stuecker, Stephanie E. Hood, Cader J. Locke, Carson L. Stacy, Qingyang Zhang and Jeffrey A. Lewis
    Citation: BMC Biology 2024 22:149
    Content type: Research article Published on:

  9. Microbiomes are generally characterized by high diversity of coexisting microbial species and strains, and microbiome composition typically remains stable across a broad range of conditions. However, under fix...

    Authors: Sanasar G. Babajanyan, Sofya K. Garushyants, Yuri I. Wolf and Eugene V. Koonin
    Citation: BMC Biology 2024 22:148
    Content type: Research article Published on:

  10. Physical activity is well known for its multiple health benefits and although the knowledge of the underlying molecular mechanisms is increasing, our understanding of the role of epigenetics in long-term train...

    Authors: Carla Geiger, Maria Needhamsen, Eric B. Emanuelsson, Jessica Norrbom, Karen Steindorf, Carl Johan Sundberg, Stefan M. Reitzner and Malene E. Lindholm
    Citation: BMC Biology 2024 22:147
    Content type: Research article Published on:

  11. Metabolic associated fatty liver disease (MAFLD), a prevalent liver disorder affecting one-third of the global population, encompasses a spectrum ranging from fatty liver to severe hepatic steatosis. Both gene...

    Authors: Wan-Yu Chi, Gang-Hui Lee, Ming-Jer Tang, Bing-Hung Chen, Wei-Ling Lin and Tzu-Fun Fu
    Citation: BMC Biology 2024 22:146
    Content type: Research article Published on:

  12. Microbes in the cold polar and alpine environments play a critical role in feedbacks that amplify the effects of climate change. Defining the cold adapted ecotype is one of the prerequisites for understanding ...

    Authors: Liang Shen, Jiayu Hu, Luyao Zhang, Zirui Wu, Liangzhong Chen, Namita Paudel Adhikari, Mukan Ji, Shaoxing Chen, Fang Peng and Yongqin Liu
    Citation: BMC Biology 2024 22:145
    Content type: Research article Published on:

  13. Diurnal and nocturnal mammals have evolved distinct pathways to optimize survival for their chronotype-specific lifestyles. Conventional rodent models, being nocturnal, may not sufficiently recapitulate the bi...

    Authors: Huirong Xie, Katrina Linning-Duffy, Elena Y. Demireva, Huishi Toh, Bana Abolibdeh, Jiaming Shi, Bo Zhou, Shigeki Iwase and Lily Yan
    Citation: BMC Biology 2024 22:144
    Content type: Methodology article Published on:

  14. The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...

    Authors: Cong Feng, Ruxiu Tie, Saige Xin, Yuhao Chen, Sida Li, Yifan Chen, Xiaotian Hu, Yincong Zhou, Yongjing Liu, Yueming Hu, Yanshi Hu, Hang Pan, Zexu Wu, Haoyu Chao, Shilong Zhang, Qingyang Ni…
    Citation: BMC Biology 2024 22:143
    Content type: Research article Published on:

  15. The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral changes in Caenorhabditis elegans. Patients with mutations in VPS50 show severe...

    Authors: Constanza Ahumada-Marchant, Carlos Ancatén-Gonzalez, Henny Haensgen, Bastian Brauer, Nicolas Merino-Veliz, Rita Droste, Felipe Arancibia, H. Robert Horvitz, Martha Constantine-Paton, Gloria Arriagada, Andrés E. Chávez and Fernando J. Bustos
    Citation: BMC Biology 2024 22:142
    Content type: Research article Published on:

  16. The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca fluviatilis, Perca schrenkii, and Sander vitreus along wi...

    Authors: Heiner Kuhl, Peter T. Euclide, Christophe Klopp, Cédric Cabau, Margot Zahm, Céline Lopez-Roques, Carole Iampietro, Claire Kuchly, Cécile Donnadieu, Romain Feron, Hugues Parrinello, Charles Poncet, Lydia Jaffrelo, Carole Confolent, Ming Wen, Amaury Herpin…
    Citation: BMC Biology 2024 22:141
    Content type: Research article Published on:

  18. The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potenti...

    Authors: Jiyoung Jang, Hyun Jung Park, Wonyoung Seong, Jiyoon Kim and Chungho Kim
    Citation: BMC Biology 2024 22:139
    Content type: Research article Published on:

  19. The vast majority of the food we eat comes from land-based agriculture, but recent technological advances in agriculture and food technology offer the prospect of producing food using substantially less or eve...

    Authors: H. Charles J. Godfray, Joseph Poore and Hannah Ritchie
    Citation: BMC Biology 2024 22:138
    Content type: Review Published on:

  20. Coevolution between modern aphids and their primary obligate, bacterial endosymbiont, Buchnera aphidicola, has been previously reported at different classification levels based on molecular phylogenetic analyses....

    Authors: Yukang Liang, Rebecca B. Dikow, Xu Su, Jun Wen and Zhumei Ren
    Citation: BMC Biology 2024 22:137
    Content type: Research article Published on:

  21. Most tail-anchored (TA) membrane proteins are delivered to the endoplasmic reticulum through a conserved posttranslational pathway. Although core mechanisms underlying the targeting and insertion of TA protein...

    Authors: Chi-Chih Chen, Yu-Ru Huang, Yuen Ting Chan, Hung-Yun Lin, Han-Jia Lin, Chwan-Deng Hsiao, Tzu-Ping Ko, Tai-Wen Lin, Ya-Hsuan Lan, Hsuan-Ya Lin and Hsin-Yang Chang
    Citation: BMC Biology 2024 22:136
    Content type: Research article Published on:

  22. Evolution of novelty is a central theme in evolutionary biology, yet studying the origins of traits with an apparently discontinuous origin remains a major challenge. Venom systems are a well-suited model for ...

    Authors: Vanessa Schendel, Carsten H. G. Müller, Matthes Kenning, Michael Maxwell, Ronald A. Jenner, Eivind A. B. Undheim and Andy Sombke
    Citation: BMC Biology 2024 22:135
    Content type: Research article Published on:

  23. Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of photoreceptors, which ultimately lead to blindness. Among the causes of this c...

    Authors: Kaifang Wang, Huijuan Xu, Rong Zou, Guangqun Zeng, Ye Yuan, Xianjun Zhu, Xiaohui Zhao, Jie Li and Lin Zhang
    Citation: BMC Biology 2024 22:134
    Content type: Research article Published on:

    The Author Correction to this article has been published in BMC Biology 2024 22:155

  24. Hepatocellular carcinoma (HCC) is a prevalent malignancy with a pressing need for improved therapeutic response and prognosis prediction. This study delves into a novel predictive model related to ferroptosis,...

    Authors: Qiong Zhou, Chunyu Tao, Yuli Ge, Jiakai Yuan, Fan Pan, Xinrong Lin and Rui Wang
    Citation: BMC Biology 2024 22:133
    Content type: Research article Published on:

  25. ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies hav...

    Authors: Tianyu Zhu, Qian Li, Zhe Zhang, Jiahao Shi, Yongyun Li, Feng Zhang, Lingjie Li, Xin Song, Jianfeng Shen and Renbing Jia
    Citation: BMC Biology 2024 22:132
    Content type: Research article Published on:

  26. Fine characterization of gene expression patterns is crucial to understand many aspects of embryonic development. The chicken embryo is a well-established and valuable animal model for developmental biology. T...

    Authors: Maëlys André, Sarah Dinvaut, Valérie Castellani and Julien Falk
    Citation: BMC Biology 2024 22:131
    Content type: Methodology article Published on:

  27. Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has resulted in the loss of the membrane-associated respiratory chain, and conse...

    Authors: Abhijith Makki, Sami Kereïche, Tien Le, Jitka Kučerová, Petr Rada, Vojtěch Žárský, Ivan Hrdý and Jan Tachezy
    Citation: BMC Biology 2024 22:130
    Content type: Research article Published on:

  28. The female locust is equipped with unique digging tools, namely two pairs of valves—a dorsal and a ventral—utilized for excavating an underground hole in which she lays her eggs. This apparatus ensures that th...

    Authors: Shmuel Gershon, Benny Bar-On, Shai Sonnenreich, Amir Ayali and Bat-El Pinchasik
    Citation: BMC Biology 2024 22:129
    Content type: Research article Published on:

  29. In yeasts belonging to the subphylum Saccharomycotina, genes encoding components of the main metabolic pathways, like alcoholic fermentation, are usually conserved. However, in fructophilic species belonging t...

    Authors: Ana Pontes, Francisca Paraíso, Margarida Silva, Catarina Lagoas, Andreia Aires, Patrícia H. Brito, Carlos A. Rosa, Marc-André Lachance, José Paulo Sampaio, Carla Gonçalves and Paula Gonçalves
    Citation: BMC Biology 2024 22:128
    Content type: Research article Published on:

  30. Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling adapt...

    Authors: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield and Andrew Ward
    Citation: BMC Biology 2024 22:127
    Content type: Research article Published on:

  31. A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing a role in initiating gene expression. Identifying promoters and their strengths can provide valuable information ...

    Authors: Yazi Li, Xiaoman Wei, Qinglin Yang, An Xiong, Xingfeng Li, Quan Zou, Feifei Cui and Zilong Zhang
    Citation: BMC Biology 2024 22:126
    Content type: Research article Published on:

  32. Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended ...

    Authors: Lubna Patel, Florent Ailloud, Sebastian Suerbaum and Christine Josenhans
    Citation: BMC Biology 2024 22:125
    Content type: Research article Published on:

  33. Regulation of transcription by DNA methylation in 5’-CpG-3’ context is a widespread mechanism allowing differential expression of genetically identical cells to persist throughout development. Consequently, di...

    Authors: Jesper Boman, Anna Qvarnström and Carina F. Mugal
    Citation: BMC Biology 2024 22:124
    Content type: Research article Published on:

  34. Various animal taxa have specialized to living with social hosts. Depending on their level of specialization, these symbiotic animals are characterized by distinct behavioural, chemical, and morphological trai...

    Authors: Thomas Parmentier, Rafael Molero-Baltanás, Catalina Valdivia, Miquel Gaju-Ricart, Pascal Boeckx, Piotr Łukasik and Nicky Wybouw
    Citation: BMC Biology 2024 22:123
    Content type: Research article Published on:

  35. The innate immune system serves as the first line of host defense. Transforming growth factor-β–activated kinase 1 (TAK1) is a key regulator of innate immunity, cell survival, and cellular homeostasis. Because...

    Authors: Ratnakar R. Bynigeri, R. K. Subbarao Malireddi, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett-Miller and Thirumala-Devi Kanneganti
    Citation: BMC Biology 2024 22:122
    Content type: Research article Published on:

  36. Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of th...

    Authors: Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri and Lynn A. Raymond
    Citation: BMC Biology 2024 22:121
    Content type: Research article Published on:

  37. Threat and individual differences in threat-processing bias perception of stimuli in the environment. Yet, their effect on perception of one’s own (body-based) self-motion in space is unknown. Here, we tested ...

    Authors: Shira Hacohen-Brown, Eva Gilboa-Schechtman and Adam Zaidel
    Citation: BMC Biology 2024 22:120
    Content type: Research article Published on:

  38. Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging.

    Authors: Hui Shi, Lei Li, Shuangshuang Mu, Shixue Gou, Xiaoyi Liu, Fangbing Chen, Menglong Chen, Qin Jin, Liangxue Lai and Kepin Wang
    Citation: BMC Biology 2024 22:119
    Content type: Research article Published on:

  39. The animal sperm shows high diversity in morphology, components, and motility. In the lepidopteran model insect, the silkworm Bombyx mori, two types of sperm, including nucleate fertile eupyrene sperm and anuclea...

    Authors: Zhongjie Zhang, Xiaojing Liu, Bo Hu, Kai Chen, Ye Yu, Chenxin Sun, Dalin Zhu, Hua Bai, Subba Reddy Palli and Anjiang Tan
    Citation: BMC Biology 2024 22:118
    Content type: Research article Published on:

  41. Verticillium wilt, caused by the fungus Verticillium dahliae, is a soil-borne vascular fungal disease, which has caused great losses to cotton yield and quality worldwide. The strain KRS010 was isolated from the ...

    Authors: Yujia Shan, Dan Wang, Fu-Hua Zhao, Jian Song, He Zhu, Yue Li, Xiao-Jun Zhang, Xiao-Feng Dai, Dongfei Han and Jie-Yin Chen
    Citation: BMC Biology 2024 22:116
    Content type: Research article Published on:

  42. Thromboinflammation is caused by mutual activation of platelets and neutrophils. The site of thromboinflammation is determined by chemoattracting agents release by endothelium, immune cells, and platelets. Imp...

    Authors: Julia-Jessica D. Korobkin, Ekaterina A. Deordieva, Ivan P. Tesakov, Ekaterina-Iva A. Adamanskaya, Anna E. Boldova, Antonina A. Boldyreva, Sofia V. Galkina, Daria P. Lazutova, Alexey A. Martyanov, Vitaly A. Pustovalov, Galina A. Novichkova, Anna Shcherbina, Mikhail A. Panteleev and Anastasia N. Sveshnikova
    Citation: BMC Biology 2024 22:115
    Content type: Research article Published on:

  43. Cotton is a major world cash crop and an important source of natural fiber, oil, and protein. Drought stress is becoming a restrictive factor affecting cotton production. To facilitate the development of droug...

    Authors: Boyang Zhang, Yuexuan Long, Liuling Pei, Xianhui Huang, Baoqi Li, Bei Han, Mengmeng Zhang, Keith Lindsey, Xianlong Zhang, Maojun Wang and Xiyan Yang
    Citation: BMC Biology 2024 22:114
    Content type: Research article Published on:

  44. Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic l...

    Authors: Liman Zhang, Huibin Wang, Chaoling Xue, Yin Liu, Yao Zhang, Zhiguo Liu, Xiangrui Meng, Mengjun Liu and Jin Zhao
    Citation: BMC Biology 2024 22:113
    Content type: Research article Published on:

  45. Fungi and ants belong to the most important organisms in terrestrial ecosystems on Earth. In nutrient-poor niches of tropical rainforests, they have developed steady ecological relationships as a successful su...

    Authors: Veronica Barrajon-Santos, Maximilian Nepel, Bela Hausmann, Hermann Voglmayr, Dagmar Woebken and Veronika E. Mayer
    Citation: BMC Biology 2024 22:112
    Content type: Research article Published on:

  46. Juvenile hormones (JH) play crucial role in regulating development and reproduction in insects. The most common form of JH is JH III, derived from MF through epoxidation by CYP15 enzymes. However, in the highe...

    Authors: Qiangqiang Jia, Liu Yang, Jiamin Wen, Suning Liu, Di Wen, Wei Luo, Weihua Wang, Subba Reddy Palli and Li Sheng
    Citation: BMC Biology 2024 22:111
    Content type: Research article Published on:

  47. Plants differ more than threefold in seed oil contents (SOCs). Soybean (Glycine max), cotton (Gossypium hirsutum), rapeseed (Brassica napus), and sesame (Sesamum indicum) are four important oil crops with markedl...

    Authors: Jinwen Chen, Yan Hu, Ting Zhao, Chujun Huang, Jiani Chen, Lu He, Fan Dai, Shuqi Chen, Luyao Wang, Shangkun Jin and Tianzhen Zhang
    Citation: BMC Biology 2024 22:110
    Content type: Research article Published on:

  48. Social insects vary considerably in their social organization both between and within species. In the California harvester ant, Pogonomyrmex californicus (Buckley 1867), colonies are commonly founded and headed b...

    Authors: Mohammed Errbii, Ulrich R. Ernst, Aparna Lajmi, Eyal Privman, Jürgen Gadau and Lukas Schrader
    Citation: BMC Biology 2024 22:109
    Content type: Research article Published on:

  49. Populations of the plant pathogenic fungus Verticillium dahliae display a complex and rich genetic diversity, yet the existence of sexual reproduction in the fungus remains contested. As pivotal genes, MAT genes ...

    Authors: Ya-Duo Zhang, Xiao-Bin Ji, Juan Zong, Xiao-Feng Dai, Steven J. Klosterman, Krishna V. Subbarao, Dan-Dan Zhang and Jie-Yin Chen
    Citation: BMC Biology 2024 22:108
    Content type: Research article Published on:
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