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  1. Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging.

    Authors: Hui Shi, Lei Li, Shuangshuang Mu, Shixue Gou, Xiaoyi Liu, Fangbing Chen, Menglong Chen, Qin Jin, Liangxue Lai and Kepin Wang
    Citation: BMC Biology 2024 22:119
  2. The animal sperm shows high diversity in morphology, components, and motility. In the lepidopteran model insect, the silkworm Bombyx mori, two types of sperm, including nucleate fertile eupyrene sperm and anuclea...

    Authors: Zhongjie Zhang, Xiaojing Liu, Bo Hu, Kai Chen, Ye Yu, Chenxin Sun, Dalin Zhu, Hua Bai, Subba Reddy Palli and Anjiang Tan
    Citation: BMC Biology 2024 22:118
  3. Verticillium wilt, caused by the fungus Verticillium dahliae, is a soil-borne vascular fungal disease, which has caused great losses to cotton yield and quality worldwide. The strain KRS010 was isolated from the ...

    Authors: Yujia Shan, Dan Wang, Fu-Hua Zhao, Jian Song, He Zhu, Yue Li, Xiao-Jun Zhang, Xiao-Feng Dai, Dongfei Han and Jie-Yin Chen
    Citation: BMC Biology 2024 22:116
  4. Thromboinflammation is caused by mutual activation of platelets and neutrophils. The site of thromboinflammation is determined by chemoattracting agents release by endothelium, immune cells, and platelets. Imp...

    Authors: Julia-Jessica D. Korobkin, Ekaterina A. Deordieva, Ivan P. Tesakov, Ekaterina-Iva A. Adamanskaya, Anna E. Boldova, Antonina A. Boldyreva, Sofia V. Galkina, Daria P. Lazutova, Alexey A. Martyanov, Vitaly A. Pustovalov, Galina A. Novichkova, Anna Shcherbina, Mikhail A. Panteleev and Anastasia N. Sveshnikova
    Citation: BMC Biology 2024 22:115
  5. Cotton is a major world cash crop and an important source of natural fiber, oil, and protein. Drought stress is becoming a restrictive factor affecting cotton production. To facilitate the development of droug...

    Authors: Boyang Zhang, Yuexuan Long, Liuling Pei, Xianhui Huang, Baoqi Li, Bei Han, Mengmeng Zhang, Keith Lindsey, Xianlong Zhang, Maojun Wang and Xiyan Yang
    Citation: BMC Biology 2024 22:114
  6. Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic l...

    Authors: Liman Zhang, Huibin Wang, Chaoling Xue, Yin Liu, Yao Zhang, Zhiguo Liu, Xiangrui Meng, Mengjun Liu and Jin Zhao
    Citation: BMC Biology 2024 22:113
  7. Fungi and ants belong to the most important organisms in terrestrial ecosystems on Earth. In nutrient-poor niches of tropical rainforests, they have developed steady ecological relationships as a successful su...

    Authors: Veronica Barrajon-Santos, Maximilian Nepel, Bela Hausmann, Hermann Voglmayr, Dagmar Woebken and Veronika E. Mayer
    Citation: BMC Biology 2024 22:112
  8. Juvenile hormones (JH) play crucial role in regulating development and reproduction in insects. The most common form of JH is JH III, derived from MF through epoxidation by CYP15 enzymes. However, in the highe...

    Authors: Qiangqiang Jia, Liu Yang, Jiamin Wen, Suning Liu, Di Wen, Wei Luo, Weihua Wang, Subba Reddy Palli and Li Sheng
    Citation: BMC Biology 2024 22:111
  9. Plants differ more than threefold in seed oil contents (SOCs). Soybean (Glycine max), cotton (Gossypium hirsutum), rapeseed (Brassica napus), and sesame (Sesamum indicum) are four important oil crops with markedl...

    Authors: Jinwen Chen, Yan Hu, Ting Zhao, Chujun Huang, Jiani Chen, Lu He, Fan Dai, Shuqi Chen, Luyao Wang, Shangkun Jin and Tianzhen Zhang
    Citation: BMC Biology 2024 22:110
  10. Social insects vary considerably in their social organization both between and within species. In the California harvester ant, Pogonomyrmex californicus (Buckley 1867), colonies are commonly founded and headed b...

    Authors: Mohammed Errbii, Ulrich R. Ernst, Aparna Lajmi, Eyal Privman, Jürgen Gadau and Lukas Schrader
    Citation: BMC Biology 2024 22:109
  11. Populations of the plant pathogenic fungus Verticillium dahliae display a complex and rich genetic diversity, yet the existence of sexual reproduction in the fungus remains contested. As pivotal genes, MAT genes ...

    Authors: Ya-Duo Zhang, Xiao-Bin Ji, Juan Zong, Xiao-Feng Dai, Steven J. Klosterman, Krishna V. Subbarao, Dan-Dan Zhang and Jie-Yin Chen
    Citation: BMC Biology 2024 22:108
  12. Histone H3K4 tri-methylation (H3K4me3) catalyzed by Set1/COMPASS, is a prominent epigenetic mark found in promoter-proximal regions of actively transcribed genes. H3K4me3 relies on prior monoubiquitination at ...

    Authors: Junsoo Oh, Shinae Park, Jueun Kim, Soojin Yeom, Ji Min Lee, Eun-Jin Lee, Yong-Joon Cho and Jung-Shin Lee
    Citation: BMC Biology 2024 22:105
  13. Gonadotropin precisely controls mammalian reproductive activities. Systematic analysis of the mechanisms by which epigenetic modifications regulate the synthesis and secretion of gonadotropin can be useful for...

    Authors: Hao-Qi Wang, Yi-Ran Ma, Yu-Xin Zhang, Fan-Hao Wei, Yi Zheng, Zhong-Hao Ji, Hai-Xiang Guo, Tian Wang, Jia-Bao Zhang and Bao Yuan
    Citation: BMC Biology 2024 22:104
  14. Ascetosporea (Endomyxa, Rhizaria) is a group of unicellular parasites infecting aquatic invertebrates. They are increasingly being recognized as widespread and important in marine environments, causing large a...

    Authors: Markus Hiltunen Thorén, Ioana Onuț-Brännström, Anders Alfjorden, Hana Pecková, Fiona Swords, Chantelle Hooper, Astrid S. Holzer, David Bass and Fabien Burki
    Citation: BMC Biology 2024 22:103
  15. Sex-limited chromosomes Y and W share some characteristics, including the degeneration of protein-coding genes, enrichment of repetitive elements, and heterochromatin. However, although many studies have sugge...

    Authors: Wenting Dai, Judith E. Mank and Liping Ban
    Citation: BMC Biology 2024 22:102
  16. CRISPR-Cas9 genome editing often induces unintended, large genomic rearrangements, posing potential safety risks. However, there are no methods for mitigating these risks.

    Authors: Baolei Yuan, Chongwei Bi, Yeteng Tian, Jincheng Wang, Yiqing Jin, Khaled Alsayegh, Muhammad Tehseen, Gang Yi, Xuan Zhou, Yanjiao Shao, Fernanda Vargas Romero, Wolfgang Fischle, Juan Carlos Izpisua Belmonte, Samir Hamdan, Yanyi Huang and Mo Li
    Citation: BMC Biology 2024 22:101
  17. Plant pathogens secrete effector proteins into host cells to suppress immune responses and manipulate fundamental cellular processes. One of these processes is autophagy, an essential recycling mechanism in eu...

    Authors: Serena Testi, Marie-Line Kuhn, Valérie Allasia, Pascaline Auroy, Fantao Kong, Gilles Peltier, Sophie Pagnotta, Julie Cazareth, Harald Keller and Franck Panabières
    Citation: BMC Biology 2024 22:100
  18. The ability of animals to regenerate damaged tissue is a complex process that involves various cellular mechanisms. As animals age, they lose their regenerative abilities, making it essential to understand the...

    Authors: Sara Ahmed-de-Prado, Carlos Estella and Antonio Baonza
    Citation: BMC Biology 2024 22:98
  19. The early Cambrian arthropod clade Megacheira, also referred to as great appendage arthropods, comprised a group of diminutive and elongated predators during the early Palaeozoic era, around 518 million years ...

    Authors: Michel Schmidt, Xianguang Hou, Huijuan Mai, Guixian Zhou, Roland R. Melzer, Xilin Zhang and Yu Liu
    Citation: BMC Biology 2024 22:96
  20. The medial prefrontal cortex (mPFC) is involved in complex functions containing multiple types of neurons in distinct subregions with preferential roles. The pyramidal neurons had wide-range projections to cor...

    Authors: Ayizuohere Tudi, Mei Yao, Feifang Tang, Jiandong Zhou, Anan Li, Hui Gong, Tao Jiang and Xiangning Li
    Citation: BMC Biology 2024 22:95
  21. Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron (SMN) protein. SMA presents across a broad spectrum of disease severity....

    Authors: Eric L. Garcia, Rebecca E. Steiner, Amanda C. Raimer, Laura E. Herring, A. Gregory Matera and Ashlyn M. Spring
    Citation: BMC Biology 2024 22:94
  22. The human upper respiratory tract (URT) microbiome, like the gut microbiome, varies across individuals and between health and disease states. However, study-to-study heterogeneity in reported case–control resu...

    Authors: Nick Quinn-Bohmann, Jose A. Freixas-Coutin, Jin Seo, Ruth Simmons, Christian Diener and Sean M. Gibbons
    Citation: BMC Biology 2024 22:93
  23. Transposable elements (TEs) have a profound influence on the trajectory of plant evolution, driving genome expansion and catalyzing phenotypic diversification. The pangenome, a comprehensive genetic pool encom...

    Authors: Xin He, Zhengyang Qi, Zhenping Liu, Xing Chang, Xianlong Zhang, Jianying Li and Maojun Wang
    Citation: BMC Biology 2024 22:92
  24. Elephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protectio...

    Authors: Kaitlin N. Allen, Julia María Torres-Velarde, Juan Manuel Vazquez, Diana D. Moreno-Santillán, Peter H. Sudmant and José Pablo Vázquez-Medina
    Citation: BMC Biology 2024 22:91
  25. Innate immune responses can be activated by pathogen-associated molecular patterns (PAMPs), danger signals released by damaged tissues, or the absence of self-molecules that inhibit immunity. As PAMPs are typi...

    Authors: Alexandre B. Leitão, Ramesh Arunkumar, Jonathan P. Day, Nancy Hanna, Aarathi Devi, Matthew P. Hayes and Francis M. Jiggins
    Citation: BMC Biology 2024 22:89
  26. Immunosuppressive status is prevalent in cancer patients and increases the complexity of tumor immunotherapy. It has been found that Listeria-vectored tumor vaccines had the potential ability of two-side regulato...

    Authors: Yunwen Zhang, Yao Lei, Qian Ou, Mengdie Chen, Sicheng Tian, Jing Tang, Ruidan Li, Qian Liang, Zhaobin Chen and Chuan Wang
    Citation: BMC Biology 2024 22:88
  27. Cyprinidae, the largest fish family, encompasses approximately 367 genera and 3006 species. While they exhibit remarkable adaptability to diverse aquatic environments, it is exceptionally rare to find them in ...

    Authors: Ying Wang, Xuejing Zhang, Jing Wang, Cheng Wang, Fei Xiong, Yuting Qian, Minghui Meng, Min Zhou, Wenjun Chen, Zufa Ding, Dan Yu, Yang Liu, Yumei Chang, Shunping He and Liandong Yang
    Citation: BMC Biology 2024 22:87
  28. The blood–brain barrier serves as a critical interface between the bloodstream and brain tissue, mainly composed of pericytes, neurons, endothelial cells, and tightly connected basal membranes. It plays a pivo...

    Authors: Zhi-Feng Gu, Yu-Duo Hao, Tian-Yu Wang, Pei-Ling Cai, Yang Zhang, Ke-Jun Deng, Hao Lin and Hao Lv
    Citation: BMC Biology 2024 22:86
  29. Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3. We previously reported...

    Authors: Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang and Xin-Hai Pei
    Citation: BMC Biology 2024 22:85
  30. Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional reg...

    Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel and Y. Jessie Zhang
    Citation: BMC Biology 2024 22:83
  31. As an endemic shrub of the Qinghai-Tibetan Plateau (QTP), the distribution of Hippophae tibetana Schlecht. ranges between 2800 and 5200 m above sea level. As the most basal branch of the Hippophae genus, H. tibet...

    Authors: Guoyun Zhang, Yating Song, Ning Chen, Jihua Wei, Jianguo Zhang and Caiyun He
    Citation: BMC Biology 2024 22:82
  32. Response to oxidative stress is universal in almost all organisms and the mitochondrial membrane protein, BbOhmm, negatively affects oxidative stress responses and virulence in the insect fungal pathogen, Beauver...

    Authors: Yanze Kan, Zhangjiang He, Nemat O. Keyhani, Ning Li, Shuaishuai Huang, Xin Zhao, Pengfei Liu, Fanqin Zeng, Min Li, Zhibing Luo and Yongjun Zhang
    Citation: BMC Biology 2024 22:81
  33. The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compa...

    Authors: Yaxin Cao, Hengyu Yan, Minghao Sheng, Yue Liu, Xinyue Yu, Zhongqiu Li, Wenying Xu and Zhen Su
    Citation: BMC Biology 2024 22:80
  34. Throughout its nearly four-billion-year history, life has undergone evolutionary transitions in which simpler subunits have become integrated to form a more complex whole. Many of these transitions opened the ...

    Authors: Charles Ross Lindsey, Andrew H. Knoll, Matthew D. Herron and Frank Rosenzweig
    Citation: BMC Biology 2024 22:79
  35. Regulation of transcription is central to the emergence of new cell types during development, and it often involves activation of genes via proximal and distal regulatory regions. The activity of regulatory el...

    Authors: Irina Abnizova, Carine Stapel, Rene te Boekhorst, Jimmy Tsz Hang Lee and Martin Hemberg
    Citation: BMC Biology 2024 22:78
  36. Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of ...

    Authors: Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian Høj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Takeshi Kurita and Mette Marie Rosenkilde
    Citation: BMC Biology 2024 22:77
  37. The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely rel...

    Authors: Jinyou Yang, Toma Isaka, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa
    Citation: BMC Biology 2024 22:76
  38. Trans-differentiation of human-induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons a likely significant advance for disease model...

    Authors: D. Das, S. Sonthalia, G. Stein-O.’Brien, MH. Wahbeh, K. Feuer, L. Goff, C. Colantuoni, V. Mahairaki and D. Avramopoulos
    Citation: BMC Biology 2024 22:75
  39. The tunicates form a group of filter-feeding marine animals closely related to vertebrates. They share with them a number of features such as a notochord and a dorsal neural tube in the tadpole larvae of ascid...

    Authors: Maxence Lanoizelet, Christel Elkhoury Youhanna, Agnès Roure and Sébastien Darras
    Citation: BMC Biology 2024 22:74
  40. Quorum sensing (QS) is the ability of microorganisms to assess local clonal density by measuring the extracellular concentration of signal molecules that they produce and excrete. QS is also the only known way...

    Authors: Tamás Czárán, István Scheuring, István Zachar and Szabolcs Számadó
    Citation: BMC Biology 2024 22:73
  41. Authors: Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett, Caitlin H. Miller, Summer X. Hardy, Matthew K. Arthur, Adam M. Greenstein, Melanie S. Colvin, Lucie M. Michel, Andrew H. Moeller and Michael J. Sheehan
    Citation: BMC Biology 2024 22:72

    The original article was published in BMC Biology 2024 22:35

  42. Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewi...

    Authors: Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado and Rafael R. Daga
    Citation: BMC Biology 2024 22:71
  43. The brown planthopper (BPH) is a kind of piercing-sucking insect specific to rice, with the damage tops the list of pathogens and insects in recent years. microRNAs (miRNAs) are pivotal regulators of plant–env...

    Authors: Bo Sun, Yanjie Shen, Lin Zhu, Xiaofang Yang, Xue Liu, Dayong Li, Mulan Zhu, Xuexia Miao and Zhenying Shi
    Citation: BMC Biology 2024 22:68
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