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  1. Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.

    Authors: Madeleine Birgersson, Rajitha Indukuri, Linnéa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer and Cecilia Williams
    Citation: BMC Biology 2023 21:277
  2. Many organisms rely on mineral nutrients taken directly from the soil or aquatic environment, and therefore, developed mechanisms to cope with the limitation of a given essential nutrient. For example, photosy...

    Authors: Stéphanie Bolik, Alexander Schlaich, Tetiana Mukhina, Alberto Amato, Olivier Bastien, Emanuel Schneck, Bruno Demé and Juliette Jouhet
    Citation: BMC Biology 2023 21:275
  3. Aedes aegypti (Ae. aegypti) is the major vector that transmits many diseases including dengue, Zika, and filariasis in tropical and subtropical regions. Due to the growing resistance to chemical-based insecticide...

    Authors: Heng Zhang, Emma Trueman, Xinjun Hou, De Xian Chew, Lu Deng, Jonathan Liew, Tania Chia, Zhiyong Xi, Cheong Huat Tan and Yu Cai
    Citation: BMC Biology 2023 21:274
  4. Sex differences in microRNA (miRNA) expression profiles have been found across multiple tissues. Skeletal muscle is one of the most sex-biased tissues of the body. MiRNAs are necessary for development and have...

    Authors: Danielle Hiam, Shanie Landen, Macsue Jacques, Sarah Voisin, Séverine Lamon and Nir Eynon
    Citation: BMC Biology 2023 21:273
  5. Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While a plethora of studies have connected a significant fraction of human D...

    Authors: Dongyang Xu, Lu Tang, Junjun Zhou, Fang Wang, Huifen Cao, Yu Huang and Philipp Kapranov
    Citation: BMC Biology 2023 21:271
  6. Microbiome analysis is becoming a standard component in many scientific studies, but also requires extensive quality control of the 16S rRNA gene sequencing data prior to analysis. In particular, when investig...

    Authors: Claudia Hülpüsch, Luise Rauer, Thomas Nussbaumer, Vera Schwierzeck, Madhumita Bhattacharyya, Veronika Erhart, Claudia Traidl-Hoffmann, Matthias Reiger and Avidan U. Neumann
    Citation: BMC Biology 2023 21:269
  7. Mayflies are basal winged insects of crucial importance for the understanding of the early evolution of Pterygota. Unlike all other insects, they have two successive winged stages, the subimago and the imago. ...

    Authors: Eduardo Domínguez, Thomas van de Kamp, István Mikó, M. Gabriela Cuezzo and Arnold H. Staniczek
    Citation: BMC Biology 2023 21:268
  8. The red junglefowl, the wild outgroup of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of c...

    Authors: Edward S. Rice, Antton Alberdi, James Alfieri, Giridhar Athrey, Jennifer R. Balacco, Philippe Bardou, Heath Blackmon, Mathieu Charles, Hans H. Cheng, Olivier Fedrigo, Steven R. Fiddaman, Giulio Formenti, Laurent A. F. Frantz, M. Thomas P. Gilbert, Cari J. Hearn, Erich D. Jarvis…
    Citation: BMC Biology 2023 21:267
  9. Unlike most free-living platyhelminths, catenulids, the sister group to all remaining flatworms, do not have eyes. Instead, the most prominent sensory structures in their heads are statocysts or sensory pits. ...

    Authors: Ludwik Gąsiorowski, Isabel Lucia Dittmann, Jeremias N. Brand, Torben Ruhwedel, Wiebke Möbius, Bernhard Egger and Jochen C. Rink
    Citation: BMC Biology 2023 21:266
  10. Lepidoptera is one of the most species-rich animal groups, with substantial karyotype variations among species due to chromosomal rearrangements. Knowledge of the evolutionary patterns of lepidopteran chromoso...

    Authors: Xi Chen, Zuoqi Wang, Chaowei Zhang, Jingheng Hu, Yueqi Lu, Hang Zhou, Yang Mei, Yuyang Cong, Fangyuan Guo, Yaqin Wang, Kang He, Ying Liu and Fei Li
    Citation: BMC Biology 2023 21:265
  11. Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating c...

    Authors: Miao Wang, Bing He, Yueling Hao, Divyaa Srinivasan, Jatin Shrinet and Peter Fraser
    Citation: BMC Biology 2023 21:264
  12. RNA editing by adenosine deaminase acting on RNA (ADAR) occurs in all metazoans and fulfils several functions. Here, we examined effects of acclimation temperature (27 °C, 18 °C,13 °C) on editing patterns in six ...

    Authors: Wenhao Li, Mengdi Bu, Ruiqin Hu, Shouwen Jiang, Liangbiao Chen and George N. Somero
    Citation: BMC Biology 2023 21:262
  13. Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activi...

    Authors: Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis and Thomas Klein
    Citation: BMC Biology 2023 21:260
  14. The endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCS) are extensively studied in aerobic eukaryotes; however, little is known about MCS in anaerobes with reduced forms of mitochondria named ...

    Authors: Jitka Kučerová, Alois Zdrha, Abhishek Shinde, Karel Harant, Ivan Hrdý and Jan Tachezy
    Citation: BMC Biology 2023 21:259
  15. Mutualistic interactions, which constitute some of the most advantageous interactions among fish species, are highly vulnerable to environmental changes. A key mutualistic interaction is the cleaning service r...

    Authors: S. Ramírez-Calero, J. R. Paula, E. Otjacques, T. Ravasi, R. Rosa and C. Schunter
    Citation: BMC Biology 2023 21:258
  16. Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variati...

    Authors: Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang and Martha Constantine-Paton
    Citation: BMC Biology 2023 21:232
  17. Over evolutionary timescales, genomic loci can switch between functional and non-functional states through processes such as pseudogenization and de novo gene birth. Particularly, de novo gene birth is a wides...

    Authors: Somya Mani and Tsvi Tlusty
    Citation: BMC Biology 2023 21:257
  18. Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be inf...

    Authors: Pia Kahnau, Paul Mieske, Jenny Wilzopolski, Otto Kalliokoski, Silvia Mandillo, Sabine M. Hölter, Vootele Voikar, Adriana Amfim, Sylvia Badurek, Aleksandra Bartelik, Angela Caruso, Maša Čater, Elodie Ey, Elisabetta Golini, Anne Jaap, Dragan Hrncic…
    Citation: BMC Biology 2023 21:256
  19. SHANKs are major scaffolding proteins at postsynaptic densities (PSDs) in the central nervous system. Mutations in all three family members have been associated with neurodevelopmental disorders such as autism...

    Authors: Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Schön and Tobias M. Boeckers
    Citation: BMC Biology 2023 21:254
  20. Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecu...

    Authors: Dandan Zhu, Haihong Wang, Wei Wu, Shuaipeng Geng, Guolin Zhong, Yunfei Li, Han Guo, Guanghui Long, Qingqi Ren, Yi Luan, Chaohui Duan, Bing Wei, Jie Ma, Shiyong Li, Jun Zhou and Mao Mao
    Citation: BMC Biology 2023 21:253
  21. Diets high in saturated fat and sugar, termed “Western diets,” have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s disease (PD) is th...

    Authors: Katherine S. Morton, Jessica H. Hartman, Nathan Heffernan, Ian T. Ryde, Isabel W. Kenny-Ganzert, Lingfeng Meng, David R. Sherwood and Joel N. Meyer
    Citation: BMC Biology 2023 21:252
  22. The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene’s DNA copy number. Y...

    Authors: Samuel Hunter, Jo Hendrix, Justin Freeman, Robin D. Dowell and Mary A. Allen
    Citation: BMC Biology 2023 21:228
  23. Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the sco...

    Authors: Tram Anh Nguyen, Jia Wei Joel Heng, Yan Ting Ng, Rui Sun, Shira Fisher, Gokce Oguz, Pornchai Kaewsapsak, Shifeng Xue, Bruno Reversade, Adaikalavan Ramasamy, Eli Eisenberg and Meng How Tan
    Citation: BMC Biology 2023 21:251
  24. Nme2ABE8e has been constructed and characterized as a compact, accurate adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM: N4CC) but low editing efficiency at challenging...

    Authors: Ding Zhao, Xun Gao, Jiale Zhou, Jinze Li, Yuqiang Qian, Di Wang, Wenchao Niu, Tao Zhang, Mingyang Hu, Haoyang Xiong, Liangxue Lai and Zhanjun Li
    Citation: BMC Biology 2023 21:250
  25. Shifts in dynamic equilibria of the abundance of cellular molecules in plant-pathogen interactions need further exploration. We induced PTI in optimally growing Arabidopsis thaliana seedlings for 16 h, returning ...

    Authors: Mohammad Abukhalaf, Carsten Proksch, Domenika Thieme, Jörg Ziegler and Wolfgang Hoehenwarter
    Citation: BMC Biology 2023 21:249
  26. Open-top light-sheet microscopy (OT-LSM) is a specialized microscopic technique for the high-throughput cellular imaging of optically cleared, large-sized specimens, such as the brain. Despite the development ...

    Authors: Soohyun Park, Myeongsu Na, Sunghoe Chang and Ki Hean Kim
    Citation: BMC Biology 2023 21:248
  27. Leptosphaeria maculans “brassicae” (Lmb) and Leptosphaeria biglobosa “brassicae” (Lbb) make up a species complex involved in the stem canker (blackleg) disease of rapeseed (Brassica napus). They coinfect rapeseed...

    Authors: Elise J. Gay, Noémie Jacques, Nicolas Lapalu, Corinne Cruaud, Valerie Laval, Marie-Hélène Balesdent and Thierry Rouxel
    Citation: BMC Biology 2023 21:247
  28. The exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay (NMD). It is assembled by the splicing machinery onto mRNA in a sequence-...

    Authors: Lucía Morillo, Toni Paternina, Quentin Alasseur, Auguste Genovesio, Schraga Schwartz and Hervé Le Hir
    Citation: BMC Biology 2023 21:246
  29. Sterile-fertile heteroblasty is a common phenomenon observed in ferns, where the leaf shape of a fern sporophyll, responsible for sporangium production, differs from that of a regular trophophyll. However, due...

    Authors: Yue Zhang, Yves Van de Peer, Bei Lu, Sisi Zhang, Jingru Che, Jinming Chen, Kathleen Marchal and Xingyu Yang
    Citation: BMC Biology 2023 21:244
  30. Lactoferrin is an active protein in breast milk that plays an important role in the growth and development of infants and is implicated as a neuroprotective agent. The incidence of depression is currently incr...

    Authors: Wenli Wang, Zhimei Cheng, Xiong Wang, Qin An, Kunlun Huang, Yunping Dai, Qingyong Meng and Yali Zhang
    Citation: BMC Biology 2023 21:242
  31. Epigenetic modifications that exhibit circadian oscillations also promote circadian oscillations of gene expression. Brassica napus is a heterozygous polyploid species that has undergone distant hybridization and...

    Authors: Zhifei Xue, Baibai Gao, Guoting Chen, Jie Liu, Weizhi Ouyang, Mohamed Frahat Foda, Qing Zhang, Xiwen Zhang, Wei Zhang, Mingyue Guo, Xingwang Li and Bin Yi
    Citation: BMC Biology 2023 21:241
  32. PFTK1/Eip63E is a member of the cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E expresses primarily in postnatal and adult nervous system in Drosophila ...

    Authors: Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul R. Albert, David S. Park and Alvin Joselin
    Citation: BMC Biology 2023 21:240
  33. The Sino-Himalayan flora harbors highly diverse high-elevation biotas, but our understanding of its evolutionary history in temporal and spatial dimensions is limited. In this study, we integrated a dated phyl...

    Authors: Yun Liu, Yang-Jun Lai, Jian-Fei Ye, Hai-Hua Hu, Dan-Xiao Peng, Li-Min Lu, Hang Sun and Zhi-Duan Chen
    Citation: BMC Biology 2023 21:239
  34. Melanin plays important roles in morphological development, survival, host–pathogen interactions and in the virulence of phytopathogenic fungi. In Verticillum dahliae, increases in melanin are recognized as marke...

    Authors: Huan Li, Ruo-Cheng Sheng, Chen-Ning Zhang, Li-Chao Wang, Min Li, Ya-Hong Wang, Yu-Hang Qiao, Steven J. Klosterman, Jie-Yin Chen, Zhi-Qiang Kong, Krishna V. Subbarao, Feng-Mao Chen and Dan-Dan Zhang
    Citation: BMC Biology 2023 21:237
  35. The recruitment of effector cells is one of the novel functions described for extracellular vesicles (EVs) that needs further study. For instance, cell recruitment by mesenchymal stromal cell derived-EVs (MSC-...

    Authors: Marta Clos-Sansalvador, Marta Monguió-Tortajada, Ferran Grau-Leal, Vicenç Ruiz de Porras, Sergio G. Garcia, Marta Sanroque-Muñoz, Miriam Font-Morón, Marcella Franquesa and Francesc E. Borràs
    Citation: BMC Biology 2023 21:236
  36. Severe peripheral nerve injury (PNI) often leads to significant movement disorders and intractable pain. Therefore, promoting nerve regeneration while avoiding neuropathic pain is crucial for the clinical trea...

    Authors: Qi Chen, Xi-Yin Zhang, Yu-Pu Wang, Yun-Jie Fu, Feng Cao, Yi-Nuo Xu, Jin-Ge Kong, Na-Xi Tian, Yu Xu and Yun Wang
    Citation: BMC Biology 2023 21:235
  37. The reuse of dredged sediments in ports and lagoons is a big issue as it should not affect the quality and the equilibrium of ecosystems. In the lagoon of Venice, sediment management is of crucial importance a...

    Authors: Ilaria Bernardini, Andrea Quagliariello, Luca Peruzza, Maria Elena Martino, Giulia Dalla Rovere, Silvia Iori, Davide Asnicar, Maria Ciscato, Jacopo Fabrello, Fabiana Corami, Martina Cecchetto, Elisa Giubilato, Claudio Carrer, Cinzia Bettiol, Elena Semenzin, Antonio Marcomini…
    Citation: BMC Biology 2023 21:234
  38. The population structure of crop pathogens such as Puccinia striiformis f. sp. tritici (Pst), the cause of wheat stripe rust, is of interest to researchers looking to understand these pathogens on a molecular lev...

    Authors: Samuel Holden, Guus Bakkeren, John Hubensky, Ramandeep Bamrah, Mehrdad Abbasi, Dinah Qutob, Mei-Lan de Graaf, Sang Hu Kim, Hadley R. Kutcher, Brent D. McCallum, Harpinder S. Randhawa, Muhammad Iqbal, Keith Uloth, Rishi R. Burlakoti and Gurcharn S. Brar
    Citation: BMC Biology 2023 21:233
  39. RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited.

    Authors: Wen-Long Lei, Zongchang Du, Tie-Gang Meng, Ruibao Su, Yuan-Yuan Li, Wenbo Liu, Si-Min Sun, Meng-Yu Liu, Yi Hou, Chun-Hui Zhang, Yaoting Gui, Heide Schatten, Zhiming Han, Chenli Liu, Fei Sun, Zhen-Bo Wang…
    Citation: BMC Biology 2023 21:231
  40. Venoms, which have evolved numerous times in animals, are ideal models of convergent trait evolution. However, detailed genomic studies of toxin-encoding genes exist for only a few animal groups. The hyper-div...

    Authors: Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Günter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre…
    Citation: BMC Biology 2023 21:229
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