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  1. The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), T...

    Authors: Francesco De Logu, Gabriela Trevisan, Ilaria Maddalena Marone, Elisabetta Coppi, Diéssica Padilha Dalenogare, Mustafa Titiz, Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Simone Li Puma, Serena Materazzi, Gaetano De Siena, Pierangelo Geppetti and Romina Nassini

    Citation: BMC Biology 2020 18:197

    Content type: Research article

    Published on:

  2. Elasticity prevents fatigue of tissues that are extensively and repeatedly deformed. Resilin is a resilient and elastic extracellular protein matrix in joints and hinges of insects. For its mechanical properti...

    Authors: Steven Lerch, Renata Zuber, Nicole Gehring, Yiwen Wang, Barbara Eckel, Klaus-Dieter Klass, Fritz-Olaf Lehmann and Bernard Moussian

    Citation: BMC Biology 2020 18:195

    Content type: Research article

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  3. The vast majority of all life that ever existed on earth is now extinct and several aspects of their evolutionary history can only be assessed by using morphological data from the fossil record. Sphenodontian ...

    Authors: Tiago R. Simões, Michael W. Caldwell and Stephanie E. Pierce

    Citation: BMC Biology 2020 18:191

    Content type: Research article

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  5. The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification is produced via deamination on A34 and catalyzed by the adenosine deam...

    Authors: Xiwen Liu, Ruoyu Chen, Yujie Sun, Ran Chen, Jie Zhou, Qingnan Tian, Xuan Tao, Zhang Zhang, Guan-zheng Luo and Wei Xie

    Citation: BMC Biology 2020 18:189

    Content type: Research article

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  6. The speciation and fast global domestication of bread wheat have made a great impact on three subgenomes of bread wheat. DNA base composition is an essential genome feature, which follows the individual-strand...

    Authors: Yan Zhao, Luhao Dong, Conghui Jiang, Xueqiang Wang, Jianyin Xie, Muhammad Abdul Rehman Rashid, Yanhe Liu, Mengyao Li, Zhimu Bu, Hongwei Wang, Xin Ma, Silong Sun, Xiaoqian Wang, Cunyao Bo, Tingting Zhou and Lingrang Kong

    Citation: BMC Biology 2020 18:188

    Content type: Research article

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  7. The family Trypanosomatidae encompasses parasitic flagellates, some of which cause serious vector-transmitted diseases of humans and domestic animals. However, insect-restricted parasites represent the ancestr...

    Authors: Alexei Y. Kostygov, Alexander O. Frolov, Marina N. Malysheva, Anna I. Ganyukova, Lyudmila V. Chistyakova, Daria Tashyreva, Martina Tesařová, Viktoria V. Spodareva, Jana Režnarová, Diego H. Macedo, Anzhelika Butenko, Claudia M. d’Avila-Levy, Julius Lukeš and Vyacheslav Yurchenko

    Citation: BMC Biology 2020 18:187

    Content type: Research article

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  9. The study of convergently acquired adaptations allows fundamental insight into life’s evolutionary history. Within lepidosaur reptiles—i.e. lizards, tuatara, and snakes—a fully fossorial (‘burrowing’) lifestyl...

    Authors: Roy Ebel, Johannes Müller, Till Ramm, Christy Hipsley and Eli Amson

    Citation: BMC Biology 2020 18:185

    Content type: Research article

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  10. Ciliates are an ancient and diverse eukaryotic group found in various environments. A unique feature of ciliates is their nuclear dimorphism, by which two types of nuclei, the diploid germline micronucleus (MI...

    Authors: Yu-Hsuan Cheng, Chien-Fu Jeff Liu, Yen-Hsin Yu, Yu-Ting Jhou, Masahiro Fujishima, Isheng Jason Tsai and Jun-Yi Leu

    Citation: BMC Biology 2020 18:180

    Content type: Research article

    Published on:

  11. Survival to cold stress in insects living in temperate environments requires the deployment of strategies that lead to physiological changes involved in freeze tolerance or freeze avoidance. These strategies m...

    Authors: Bin Zhang, Lilin Zhao, Jing Ning, Jacob D. Wickham, Haokai Tian, Xiaoming Zhang, Meiling Yang, Xiangming Wang and Jianghua Sun

    Citation: BMC Biology 2020 18:184

    Content type: Research article

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  13. Visually guided behaviors such as optomotor and optokinetic responses, phototaxis, and prey capture are crucial for survival in zebrafish and become apparent after just a few days of development. Color vision,...

    Authors: Chiara Fornetto, Natascia Tiso, Francesco Saverio Pavone and Francesco Vanzi

    Citation: BMC Biology 2020 18:172

    Content type: Research article

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  14. Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes...

    Authors: Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu…

    Citation: BMC Biology 2020 18:182

    Content type: Research article

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  15. Nematodes have evolved to survive in diverse ecological niches and can be a serious burden on agricultural economy, veterinary medicine, and public health. Antioxidant enzymes in parasitic nematodes play a cri...

    Authors: Lian Xu, Jian Yang, Meng Xu, Dai Shan, Zhongdao Wu and Dongjuan Yuan

    Citation: BMC Biology 2020 18:181

    Content type: Research article

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  16. A recent paper in BMC Biology entitled “A tissue level atlas of the healthy human virome” by Kumata et al. describes a meta-transcriptomic analysis of RNA-sequencing datasets from the Genotype-Tissue Expression (...

    Authors: Signe Altmäe, Nerea M. Molina and Alberto Sola-Leyva

    Citation: BMC Biology 2020 18:179

    Content type: Correspondence

    Published on:

    The original article was published in BMC Biology 2020 18:55

  17. The complex composition of different cell types within a tissue can be estimated by deconvolution of bulk gene expression profiles or with various single-cell sequencing approaches. Alternatively, DNA methylat...

    Authors: Marco Schmidt, Tiago Maié, Edgar Dahl, Ivan G. Costa and Wolfgang Wagner

    Citation: BMC Biology 2020 18:178

    Content type: Methodology article

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  18. Many biological processes, such as cancer metastasis, organismal development, and acquisition of resistance to cytotoxic therapy, rely on the emergence of rare sub-clones from a larger population. Understandin...

    Authors: David Feldman, FuNien Tsai, Anthony J. Garrity, Ryan O’Rourke, Lisa Brenan, Patricia Ho, Elizabeth Gonzalez, Silvana Konermann, Cory M. Johannessen, Rameen Beroukhim, Pratiti Bandopadhayay and Paul C. Blainey

    Citation: BMC Biology 2020 18:177

    Content type: Research article

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  21. In recent years, large-scale genetic screens using the CRISPR/Cas9 system have emerged as scalable approaches able to interrogate gene function with unprecedented efficiency and specificity in various biologic...

    Authors: Luisa Henkel, Benedikt Rauscher, Barbara Schmitt, Jan Winter and Michael Boutros

    Citation: BMC Biology 2020 18:174

    Content type: Methodology article

    Published on:

  22. It has become increasingly accepted that establishing and maintaining a complex and diverse gut microbiota is fundamental to human health. There are growing efforts to identify means of modulating and influenc...

    Authors: Lorraine A. Draper, Feargal J. Ryan, Marion Dalmasso, Pat G. Casey, Angela McCann, Vimalkumar Velayudhan, R. Paul Ross and Colin Hill

    Citation: BMC Biology 2020 18:173

    Content type: Research article

    Published on:

  23. Wheat is a powerful genetic model for studying polyploid evolution and crop domestication. Hexaploid bread wheat was formed by two rounds of interspecific hybridization and polyploidization, processes which ar...

    Authors: Jingya Yuan, Wu Jiao, Yanfeng Liu, Wenxue Ye, Xiue Wang, Bao Liu, Qingxin Song and Z. Jeffrey Chen

    Citation: BMC Biology 2020 18:171

    Content type: Research article

    Published on:

  24. Despite the widespread occurrence of axon and synaptic loss in the injured and diseased nervous system, the cellular and molecular mechanisms of these key degenerative processes remain incompletely understood....

    Authors: Alison Jane Canty, Johanna Sara Jackson, Lieven Huang, Antonio Trabalza, Cher Bass, Graham Little, Maria Tortora, Shabana Khan and Vincenzo De Paola

    Citation: BMC Biology 2020 18:170

    Content type: Research article

    Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dorith Rotenberg, Aaron A. Baumann, Sulley Ben-Mahmoud, Olivier Christiaens, Wannes Dermauw, Panagiotis Ioannidis, Chris G. C. Jacobs, Iris M. Vargas Jentzsch, Jonathan E. Oliver, Monica F. Poelchau, Swapna Priya Rajarapu, Derek J. Schneweis, Simon Snoeck, Clauvis N. T. Taning, Dong Wei, Shirani M. K. Widana Gamage…

    Citation: BMC Biology 2020 18:169

    Content type: Author Correction

    Published on:

    The original article was published in BMC Biology 2020 18:142

  26. A wide variety of photosynthetic and non-photosynthetic species sense and respond to light, having developed protective mechanisms to adapt to damaging effects on DNA and proteins. While the biology of UV ligh...

    Authors: Mikael Molin, Katarina Logg, Kristofer Bodvard, Ken Peeters, Annabelle Forsmark, Friederike Roger, Anna Jörhov, Neha Mishra, Jean-Marc Billod, Sabiha Amir, Mikael Andersson, Leif A. Eriksson, Jonas Warringer, Mikael Käll and Anders Blomberg

    Citation: BMC Biology 2020 18:168

    Content type: Research article

    Published on:

  27. Structural variants comprise diverse genomic arrangements including deletions, insertions, inversions, and translocations, which can generally be detected in humans through sequence comparison to the reference...

    Authors: Young-gun Lee, Jin-young Lee, Junhyong Kim and Young-Joon Kim

    Citation: BMC Biology 2020 18:167

    Content type: Research article

    Published on:

  28. Sensory systems acquire both external and internal information to guide behavior. Adjustments based on external input are much better documented and understood than internal-based sensory adaptations. When ext...

    Authors: Arjan Boonman, Itai Rieger, Eran Amichai, Stefan Greif, Ofri Eitan, Aya Goldshtein and Yossi Yovel

    Citation: BMC Biology 2020 18:166

    Content type: Research article

    Published on:

  29. Chromosome-level assemblies are indispensable for accurate gene prediction, synteny assessment, and understanding higher-order genome architecture. Reference and draft genomes of key helminth species have been...

    Authors: Peter D. Olson, Alan Tracey, Andrew Baillie, Katherine James, Stephen R. Doyle, Sarah K. Buddenborg, Faye H. Rodgers, Nancy Holroyd and Matt Berriman

    Citation: BMC Biology 2020 18:165

    Content type: Research article

    Published on:

  30. Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effe...

    Authors: Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G. Guerrero, Fabian Segovia-Miranda, David M. Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar and Alfonso González

    Citation: BMC Biology 2020 18:164

    Content type: Research article

    Published on:

  31. Numerous case studies have reported spontaneous regression of recognized metastases following primary tumor excision, but underlying mechanisms are elusive. Here, we present a model of regression and latency o...

    Authors: Lee Shaashua, Anabel Eckerling, Boaz Israeli, Gali Yanovich, Ella Rosenne, Suzana Fichman-Horn, Ido Ben Zvi, Liat Sorski, Rita Haldar, Ronit Satchi-Fainaro, Tamar Geiger, Erica K. Sloan and Shamgar Ben-Eliyahu

    Citation: BMC Biology 2020 18:163

    Content type: Research article

    Published on:

    The Publisher Correction to this article has been published in BMC Biology 2020 18:198

  32. Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes. In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transc...

    Authors: Ulfar Bergthorsson, Caroline J. Sheeba, Anke Konrad, Tony Belicard, Toni Beltran, Vaishali Katju and Peter Sarkies

    Citation: BMC Biology 2020 18:162

    Content type: Research article

    Published on:

  33. The Wolbachia incompatible insect technique (IIT) shows promise as a method for eliminating populations of invasive mosquitoes such as Aedes aegypti (Linnaeus) (Diptera: Culicidae) and reducing the incidence of v...

    Authors: D. E. Pagendam, B. J. Trewin, N. Snoad, S. A. Ritchie, A. A. Hoffmann, K. M. Staunton, C. Paton and N. Beebe

    Citation: BMC Biology 2020 18:161

    Content type: Research article

    Published on:

  34. Circadian rhythms across mammalian tissues are coordinated by a master clock in the suprachiasmatic nucleus (SCN) that is principally entrained by light-dark cycles. Prior investigations have shown, however, t...

    Authors: Xiaobin Xie, Ayaka Kukino, Haley E. Calcagno, Alec M. Berman, Joseph P. Garner and Matthew P. Butler

    Citation: BMC Biology 2020 18:160

    Content type: Research article

    Published on:

  35. DNA and RNA of all cellular life forms and many viruses contain an expansive repertoire of modified bases. The modified bases play diverse biological roles that include both regulation of transcription and tra...

    Authors: Ryan T. Bell, Yuri I. Wolf and Eugene V. Koonin

    Citation: BMC Biology 2020 18:159

    Content type: Research article

    Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang and Jun Yang

    Citation: BMC Biology 2020 18:158

    Content type: Author Correction

    Published on:

    The original article was published in BMC Biology 2018 16:46

  37. Insect pest control programs often use periods of insecticide treatment with intermittent breaks, to prevent fixing of mutations conferring insecticide resistance. Such mutations are typically costly in an ins...

    Authors: Anna Maria Langmüller, Viola Nolte, Ruwansha Galagedara, Rodolphe Poupardin, Marlies Dolezal and Christian Schlötterer

    Citation: BMC Biology 2020 18:157

    Content type: Research article

    Published on:

  38. The uptake of newly synthesized nuclear-encoded mitochondrial proteins from the cytosol is mediated by a complex of mitochondrial outer membrane proteins comprising a central pore-forming component and associa...

    Authors: Sebastian Kreimendahl, Jan Schwichtenberg, Kathrin Günnewig, Lukas Brandherm and Joachim Rassow

    Citation: BMC Biology 2020 18:156

    Content type: Research article

    Published on:

  39. CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting exp...

    Authors: Snehajyoti Chatterjee, Christopher C. Angelakos, Ethan Bahl, Joshua D. Hawk, Marie E. Gaine, Shane G. Poplawski, Anne Schneider-Anthony, Manish Yadav, Giulia S. Porcari, Jean-Christophe Cassel, K. Peter Giese, Jacob J. Michaelson, Lisa C. Lyons, Anne-Laurence Boutillier and Ted Abel

    Citation: BMC Biology 2020 18:155

    Content type: Research article

    Published on:

  40. Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through the derepression of targets downstream of the mitogen-activated protein kinase (MA...

    Authors: Derek Wong, Lisa Sogerer, Samantha S. Lee, Victor Wong, Amy Lum, Adrian B. Levine, Marco A. Marra and Stephen Yip

    Citation: BMC Biology 2020 18:154

    Content type: Research article

    Published on:

  41. The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic st...

    Authors: Quinn Matthews, Severino Jefferson Ribeiro da Silva, Masoud Norouzi, Lindomar José Pena and Keith Pardee

    Citation: BMC Biology 2020 18:153

    Content type: Comment

    Published on:

  42. DNA polymerase D (PolD) is the representative member of the D family of DNA polymerases. It is an archaea-specific DNA polymerase required for replication and unrelated to other known DNA polymerases. PolD con...

    Authors: Kouta Mayanagi, Keisuke Oki, Naoyuki Miyazaki, Sonoko Ishino, Takeshi Yamagami, Kosuke Morikawa, Kenji Iwasaki, Daisuke Kohda, Tsuyoshi Shirai and Yoshizumi Ishino

    Citation: BMC Biology 2020 18:152

    Content type: Research article

    Published on:

  43. Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has bee...

    Authors: Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang…

    Citation: BMC Biology 2020 18:151

    Content type: Research article

    Published on:

  44. Olive tree (Olea europaea L. subsp. europaea, Oleaceae) has been the most emblematic perennial crop for Mediterranean countries since its domestication around 6000 years ago in the Levant. Two taxonomic varieties...

    Authors: Irene Julca, Marina Marcet-Houben, Fernando Cruz, Jèssica Gómez-Garrido, Brandon S. Gaut, Concepción M. Díez, Ivo G. Gut, Tyler S. Alioto, Pablo Vargas and Toni Gabaldón

    Citation: BMC Biology 2020 18:148

    Content type: Research article

    Published on:

  45. The accumulation of mtDNA mutations in different tissues from various mouse models has been widely studied especially in the context of mtDNA mutation-driven ageing but has been confounded by the inherent limi...

    Authors: Emilie Kristine Bagge, Noriko Fujimori-Tonou, Mie Kubota-Sakashita, Takaoki Kasahara and Tadafumi Kato

    Citation: BMC Biology 2020 18:150

    Content type: Research article

    Published on:

  46. The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a ...

    Authors: Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed…

    Citation: BMC Biology 2020 18:149

    Content type: Research article

    Published on:

  48. How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed thi...

    Authors: Martin Schwersensky, Marianne Rooman and Fabrizio Pucci

    Citation: BMC Biology 2020 18:146

    Content type: Research article

    Published on:

  49. Skeletal muscle (SkM) regenerates following injury, replacing damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects leave patients with loss of function, increased re-injury...

    Authors: J. W. Fleming, A. J. Capel, R. P. Rimington, P. Wheeler, A. N. Leonard, N. C. Bishop, O. G. Davies and M. P. Lewis

    Citation: BMC Biology 2020 18:145

    Content type: Research article

    Published on:

  50. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation ...

    Authors: Sebastiaan P. van Kessel, Hiltje R. de Jong, Simon L. Winkel, Sander S. van Leeuwen, Sieger A. Nelemans, Hjalmar Permentier, Ali Keshavarzian and Sahar El Aidy

    Citation: BMC Biology 2020 18:137

    Content type: Research article

    Published on:

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