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  1. Content type: Research article

    Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and dev...

    Authors: Elke Malzer, Caia S. Dominicus, Joseph E. Chambers, Jennifer A. Dickens, Souradip Mookerjee and Stefan J. Marciniak

    Citation: BMC Biology 2018 16:34

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  2. Content type: Methodology article

    Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabdit...

    Authors: Blanca Hernando-Rodríguez, Annmary Paul Erinjeri, María Jesús Rodríguez-Palero, Val Millar, Sara González-Hernández, María Olmedo, Bettina Schulze, Ralf Baumeister, Manuel J. Muñoz, Peter Askjaer and Marta Artal-Sanz

    Citation: BMC Biology 2018 16:36

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  3. Content type: Correction

    Upon publication of the original article, Barlow et al. [1], the authors noticed that Fig. 4b contained an inaccuracy when additional data is taken into account. We inferred a loss of GRASP in the common ances...

    Authors: Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

    Citation: BMC Biology 2018 16:35

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    The original article was published in BMC Biology 2018 16:27

  4. Content type: Research article

    The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease...

    Authors: Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel and Sonia M. Brichard

    Citation: BMC Biology 2018 16:33

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  5. Content type: Research article

    Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that ...

    Authors: Asghar M. Razavi, George Khelashvili and Harel Weinstein

    Citation: BMC Biology 2018 16:31

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  6. Content type: Research article

    Eukaryotes evolved from the symbiotic association of at least two prokaryotic partners, and a good deal is known about the timings, mechanisms, and dynamics of these evolutionary steps. Recently, it was shown ...

    Authors: Raphaël Méheust, Debashish Bhattacharya, Jananan S. Pathmanathan, James O. McInerney, Philippe Lopez and Eric Bapteste

    Citation: BMC Biology 2018 16:30

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  7. Content type: Research article

    The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle’s dysfunction results in human disease. Its characteristic morphology of multiple di...

    Authors: Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

    Citation: BMC Biology 2018 16:27

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    The Correction to this article has been published in BMC Biology 2018 16:35

  8. Content type: Research article

    Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects...

    Authors: Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn and Anne J. Ridley

    Citation: BMC Biology 2018 16:29

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  9. Content type: Software

    Multiple RNA samples are frequently processed together and often mixed before multiplex sequencing in the same sequencing run. While different samples can be separated post sequencing using sample barcodes, th...

    Authors: Paul Simion, Khalid Belkhir, Clémentine François, Julien Veyssier, Jochen C. Rink, Michaël Manuel, Hervé Philippe and Maximilian J. Telford

    Citation: BMC Biology 2018 16:28

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  10. Content type: Research article

    Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrins...

    Authors: Dana A. Opulente, Emily J. Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P. Kurtzman and Chris Todd Hittinger

    Citation: BMC Biology 2018 16:26

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  11. Content type: Research article

    G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (...

    Authors: Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick and Rafael Franco

    Citation: BMC Biology 2018 16:24

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  12. Content type: Methodology article

    The ability to efficiently visualize and manipulate chromosomes is fundamental to understanding the genome architecture of organisms. Conventional chromosome preparation protocols developed for mammalian cells...

    Authors: Longhua Guo, Alice Accorsi, Shuonan He, Carlos Guerrero-Hernández, Shamilene Sivagnanam, Sean McKinney, Matthew Gibson and Alejandro Sánchez Alvarado

    Citation: BMC Biology 2018 16:25

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  13. Content type: Review

    The need for high-throughput, precise, and meaningful methods for measuring behavior has been amplified by our recent successes in measuring and manipulating neural circuitry. The largest challenges associated...

    Authors: Gordon J. Berman

    Citation: BMC Biology 2018 16:23

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  14. Content type: Review

    Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging ...

    Authors: Mel Greaves

    Citation: BMC Biology 2018 16:22

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  15. Content type: Research article

    In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other, allowing the production of organs during the ...

    Authors: Thomas Stanislas, Matthieu Pierre Platre, Mengying Liu, Léa E. S. Rambaud-Lavigne, Yvon Jaillais and Olivier Hamant

    Citation: BMC Biology 2018 16:20

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  16. Content type: Research article

    Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions and macromolecules through the pore and lea...

    Authors: Sarah C. Pearce, Arwa Al-Jawadi, Kunihiro Kishida, Shiyan Yu, Madeleine Hu, Luke F. Fritzky, Karen L. Edelblum, Nan Gao and Ronaldo P. Ferraris

    Citation: BMC Biology 2018 16:19

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  17. Content type: Research article

    Environmental stressors induce changes in endocrine state, leading to energy re-allocation from reproduction to survival. Female Drosophila melanogaster respond to thermal and nutrient stressors by arresting egg ...

    Authors: Matthew R. Meiselman, Timothy G. Kingan and Michael E. Adams

    Citation: BMC Biology 2018 16:18

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  18. Content type: Question and Answer

    Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and ...

    Authors: Meghan Lee Arnold, Ilija Melentijevic, Anna Joelle Smart and Monica Driscoll

    Citation: BMC Biology 2018 16:17

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  19. Content type: Research article

    Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-function...

    Authors: Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen and Amaury Herpin

    Citation: BMC Biology 2018 16:16

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  20. Content type: Research article

    Polyploidization is one of the major evolutionary processes that shape eukaryotic genomes, being particularly common in plants. Polyploids can arise through direct genome doubling within a species (autopolyplo...

    Authors: Irene Julca, Marina Marcet-Houben, Pablo Vargas and Toni Gabaldón

    Citation: BMC Biology 2018 16:15

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  21. Content type: Research article

    The bone morphogenetic protein (BMP) signaling gradient is central for dorsoventral patterning in amphibian embryos. This gradient is established through the interaction of several BMPs and BMP antagonists and...

    Authors: Avi Leibovich, Hadas Kot-Leibovich, Danny Ben-Zvi and Abraham Fainsod

    Citation: BMC Biology 2018 16:13

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  22. Content type: Research article

    The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only b...

    Authors: Fabian Moine, Julien Brechbühl, Monique Nenniger Tosato, Manon Beaumann and Marie-Christine Broillet

    Citation: BMC Biology 2018 16:12

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  23. Content type: Review

    Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—su...

    Authors: Elizabeth A. Craig

    Citation: BMC Biology 2018 16:11

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  24. Content type: Research article

    Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential ...

    Authors: Edward R. Ballister, Jessica Rodgers, Franck Martial and Robert J. Lucas

    Citation: BMC Biology 2018 16:10

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  25. Content type: Research article

    Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent ...

    Authors: Yi Shen, Hod Dana, Ahmed S. Abdelfattah, Ronak Patel, Jamien Shea, Rosana S. Molina, Bijal Rawal, Vladimir Rancic, Yu-Fen Chang, Lanshi Wu, Yingche Chen, Yong Qian, Matthew D. Wiens, Nathan Hambleton, Klaus Ballanyi, Thomas E. Hughes…

    Citation: BMC Biology 2018 16:9

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  26. Content type: Methodology article

    Caenorhabditis elegans nematodes are powerful model organisms, yet quantification of visible phenotypes is still often labor-intensive, biased, and error-prone. We developed WorMachine, a three-step MATLAB-based ...

    Authors: Adam Hakim, Yael Mor, Itai Antoine Toker, Amir Levine, Moran Neuhof, Yishai Markovitz and Oded Rechavi

    Citation: BMC Biology 2018 16:8

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  27. Content type: Methodology article

    Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA ...

    Authors: David Eccles, Jodie Chandler, Mali Camberis, Bernard Henrissat, Sergey Koren, Graham Le Gros and Jonathan J. Ewbank

    Citation: BMC Biology 2018 16:6

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  28. Content type: Research Article

    Structural variation contributes substantially to polymorphism within species. Chromosomal rearrangements that impact genes can lead to functional variation among individuals and influence the expression of ph...

    Authors: Clémence Plissonneau, Fanny E. Hartmann and Daniel Croll

    Citation: BMC Biology 2018 16:5

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  29. Content type: Research article

    Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric oxide synthase (iNOS) isoform has received most attention, recent studies in the literature ...

    Authors: Jon Peñarando, Laura M. López-Sánchez, Rafael Mena, Silvia Guil-Luna, Francisco Conde, Vanessa Hernández, Marta Toledano, Victoria Gudiño, Michela Raponi, Caroline Billard, Carlos Villar, César Díaz, José Gómez-Barbadillo, Juan De la Haba-Rodríguez, Kevin Myant, Enrique Aranda…

    Citation: BMC Biology 2018 16:3

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  30. Content type: Research article

    Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocyt...

    Authors: Thomas R. Lerner, Christophe J. Queval, Antony Fearns, Urska Repnik, Gareth Griffiths and Maximiliano G. Gutierrez

    Citation: BMC Biology 2018 16:1

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  31. Content type: Research article

    Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to unders...

    Authors: Yanfang Zhao, Junfang Zhang, Hualan Yang, Dongyang Cui, Jiaojiao Song, Qianqian Ma, Wenjie Luan, Bin Lai, Lan Ma, Ming Chen and Ping Zheng

    Citation: BMC Biology 2017 15:128

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  32. Content type: Review

    The trillions of microbes living in the gut—the gut microbiota—play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes de...

    Authors: Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight

    Citation: BMC Biology 2017 15:127

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  33. Content type: Methodology article

    A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance ...

    Authors: Sarah V. Biedermann, Daniel G. Biedermann, Frederike Wenzlaff, Tim Kurjak, Sawis Nouri, Matthias K. Auer, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina B. Lonsdorf and Johannes Fuss

    Citation: BMC Biology 2017 15:125

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  34. Content type: Research article

    Host sexual dimorphism is being increasingly recognized to generate strong differences in the outcome of infectious disease, but the mechanisms underlying immunological differences between males and females re...

    Authors: David F. Duneau, Hannah C. Kondolf, Joo Hyun Im, Gerardo A. Ortiz, Christopher Chow, Michael A. Fox, Ana T. Eugénio, J. Revah, Nicolas Buchon and Brian P. Lazzaro

    Citation: BMC Biology 2017 15:124

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  35. Content type: Methodology article

    Clonal microbial populations often harbor rare phenotypic variants that are typically hidden within the majority of the remaining cells, but are crucial for the population’s resilience to external perturbation...

    Authors: Rosemary A. Bamford, Ashley Smith, Jeremy Metz, Georgina Glover, Richard W. Titball and Stefano Pagliara

    Citation: BMC Biology 2017 15:121

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  36. Content type: Research article

    Intestinal bacteria are known to regulate bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth factor 19 through intestinal nuclear farnesoi...

    Authors: Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li and Wei Jia

    Citation: BMC Biology 2017 15:120

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  37. Content type: Research article

    Telomere length heterogeneity has been detected in various cell types, including stem cells and cancer cells. Cell heterogeneity in pluripotent stem cells, such as embryonic stem cells (ESCs), is of particular...

    Authors: Hua Wang, Kunshan Zhang, Yifei Liu, Yudong Fu, Shan Gao, Peng Gong, Haiying Wang, Zhongcheng Zhou, Ming Zeng, Zhenfeng Wu, Yu Sun, Tong Chen, Siguang Li and Lin Liu

    Citation: BMC Biology 2017 15:114

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  38. Content type: Research article

    Climate change causes the breakdown of the symbiotic relationships between reef-building corals and their photosynthetic symbionts (genus Symbiodinium), with thermal anomalies in 2015–2016 triggering the most wid...

    Authors: Stephanie G. Gardner, Jean-Baptiste Raina, Matthew R. Nitschke, Daniel A. Nielsen, Michael Stat, Cherie A. Motti, Peter J. Ralph and Katherina Petrou

    Citation: BMC Biology 2017 15:117

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