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  1. Authors: Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett, Caitlin H. Miller, Summer X. Hardy, Matthew K. Arthur, Adam M. Greenstein, Melanie S. Colvin, Lucie M. Michel, Andrew H. Moeller and Michael J. Sheehan
    Citation: BMC Biology 2024 22:72
    Content type: Correction Published on:

    The original article was published in BMC Biology 2024 22:35

  2. Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewi...

    Authors: Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado and Rafael R. Daga
    Citation: BMC Biology 2024 22:71
    Content type: Research article Published on:

  3. Eriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The higher-level phylogeny of eriophyoid mites, however, remains unresolved due to the limited n...

    Authors: Qi Zhang, Yi-Wen Lu, Xin-Yu Liu, Ye Li, Wei-Nan Gao, Jing-Tao Sun, Xiao-Yue Hong, Renfu Shao and Xiao-Feng Xue
    Citation: BMC Biology 2024 22:70
    Content type: Research article Published on:

  4. Recently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME). Nevertheless, researches on the clinical significance of TIME-related lncRNAs are li...

    Authors: Yuqing Ren, Ruhao Wu, Chunwei Li, Long Liu, Lifeng Li, Siyuan Weng, Hui Xu, Zhe Xing, Yuyuan Zhang, Libo Wang, Zaoqu Liu and Xinwei Han
    Citation: BMC Biology 2024 22:69
    Content type: Research article Published on:

  5. The brown planthopper (BPH) is a kind of piercing-sucking insect specific to rice, with the damage tops the list of pathogens and insects in recent years. microRNAs (miRNAs) are pivotal regulators of plant–env...

    Authors: Bo Sun, Yanjie Shen, Lin Zhu, Xiaofang Yang, Xue Liu, Dayong Li, Mulan Zhu, Xuexia Miao and Zhenying Shi
    Citation: BMC Biology 2024 22:68
    Content type: Research article Published on:

  6. Insects have evolved complex visual systems and display an astonishing range of adaptations for diverse ecological niches. Species of Drosophila melanogaster subgroup exhibit extensive intra- and interspecific di...

    Authors: Alexandra D. Buffry, John P. Currea, Franziska A. Franke-Gerth, Ravindra Palavalli-Nettimi, Andrew J. Bodey, Christoph Rau, Nazanin Samadi, Stefan J. Gstöhl, Christian M. Schlepütz, Alistair P. McGregor, Lauren Sumner-Rooney, Jamie Theobald and Maike Kittelmann
    Citation: BMC Biology 2024 22:67
    Content type: Research article Published on:

  7. Antibody drug conjugates (ADCs) constitute a promising class of targeted anti-tumor therapeutics that harness the selectivity of monoclonal antibodies with the potency of cytotoxic drugs. ADC development is be...

    Authors: Trevor S. Anderson, Amanda L. McCormick, Savanna L. Smith and Devin B. Lowe
    Citation: BMC Biology 2024 22:66
    Content type: Research article Published on:

  8. DNA methylation has been documented to play vital roles in diseases and biological processes. In bovine, little is known about the regulatory roles of DNA methylation alterations on production and health trait...

    Authors: Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Marc-André Sirard and Eveline M. Ibeagha-Awemu
    Citation: BMC Biology 2024 22:65
    Content type: Research article Published on:

  10. Obligate blood-feeding insects obtain the nutrients and water necessary to ensure survival from the vertebrate blood. The internal taste sensilla, situated in the pharynx, evaluate the suitability of the inges...

    Authors: Isabel Ortega-Insaurralde, José Manuel Latorre-Estivalis, Andre Luis Costa-da-Silva, Agustina Cano, Teresita C. Insausti, Héctor Salas Morales, Gina Pontes, Martín Berón de Astrada, Sheila Ons, Matthew DeGennaro and Romina B. Barrozo
    Citation: BMC Biology 2024 22:63
    Content type: Research article Published on:

  12. Ecosystems are brimming with myriad compounds, including some at very low concentrations that are indispensable for insect survival and reproduction. Screening strategies for identifying active compounds are t...

    Authors: Yipeng Liu, Sai Zhang, Song Cao, Emmanuelle Jacquin-Joly, Qiong Zhou, Yang Liu and Guirong Wang
    Citation: BMC Biology 2024 22:61
    Content type: Research article Published on:

  13. Mitochondria participate in various cellular processes including energy metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses, inflammation and immunity. However, the role o...

    Authors: Laura Vesala, Yuliya Basikhina, Tea Tuomela, Anssi Nurminen, Emilia Siukola, Pedro F. Vale and Tiina S. Salminen
    Citation: BMC Biology 2024 22:60
    Content type: Research article Published on:

  14. Hmong–Mien (HM) speakers are linguistically related and live primarily in China, but little is known about their ancestral origins or the evolutionary mechanism shaping their genomic diversity. In particular, ...

    Authors: Yang Gao, Xiaoxi Zhang, Hao Chen, Yan Lu, Sen Ma, Yajun Yang, Menghan Zhang and Shuhua Xu
    Citation: BMC Biology 2024 22:59
    Content type: Research article Published on:

  15. Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the dif...

    Authors: Camille Fourneaux, Laëtitia Racine, Catherine Koering, Sébastien Dussurgey, Elodie Vallin, Alice Moussy, Romuald Parmentier, Fanny Brunard, Daniel Stockholm, Laurent Modolo, Franck Picard, Olivier Gandrillon, Andras Paldi and Sandrine Gonin-Giraud
    Citation: BMC Biology 2024 22:58
    Content type: Research article Published on:

  16. Authors: Zhikang Hu, Zhengqi Fan, Sijia Li, Minyan Wang, Mingchuan Huang, Xianjin Ma, Weixin Liu, Yupeng Wang, Yifan Yu, Yaxuan Li, Yingkun Sun, Xinlei Li, Jiyuan Li and Hengfu Yin
    Citation: BMC Biology 2024 22:57
    Content type: Author Correction Published on:

    The original article was published in BMC Biology 2024 22:50

  17. RNA-seq is a fundamental technique in genomics, yet reference bias, where transcripts derived from non-reference alleles are quantified less accurately, can undermine the accuracy of RNA-seq quantification and...

    Authors: Benedict Coombes, Thomas Lux, Eduard Akhunov and Anthony Hall
    Citation: BMC Biology 2024 22:56
    Content type: Research article Published on:

  18. The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the precision medicine era and complete understanding of their genetic formation, admixture...

    Authors: Qiuxia Sun, Mengge Wang, Tao Lu, Shuhan Duan, Yan Liu, Jing Chen, Zhiyong Wang, Yuntao Sun, Xiangping Li, Shaomei Wang, Liuyi Lu, Liping Hu, Libing Yun, Junbao Yang, Jiangwei Yan, Shengjie Nie…
    Citation: BMC Biology 2024 22:55
    Content type: Research article Published on:

  19. Gut bacteria are beneficial to the host, many of which must be passed on to host offspring. During metamorphosis, the midgut of holometabolous insects undergoes histolysis and remodeling, and thus risks losing...

    Authors: Pei Xiong, Wen-Wen Wang, Xu-Sheng Liu, Yu-Feng Wang and Jia-Lin Wang
    Citation: BMC Biology 2024 22:54
    Content type: Research article Published on:

  20. Plant diseases are driven by an intricate set of defense mechanisms counterbalanced by the expression of host susceptibility factors promoted through the action of pathogen effectors. In spite of their central...

    Authors: Florian Rocher, Samir Dou, Géraldine Philippe, Marie-Laure Martin, Philippe Label, Thierry Langin and Ludovic Bonhomme
    Citation: BMC Biology 2024 22:53
    Content type: Research article Published on:

  21. Capsella bursa-pastoris, a cosmopolitan weed of hybrid origin, is an emerging model object for the study of early consequences of polyploidy, being a fast growing annual and a close relative of Arabidopsis thalia...

    Authors: Aleksey A. Penin, Artem S. Kasianov, Anna V. Klepikova, Denis O. Omelchenko, Maksim S. Makarenko and Maria D. Logacheva
    Citation: BMC Biology 2024 22:52
    Content type: Research article Published on:

  22. Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, both at the cellular and molecular levels. Here, we identify a novel role for Sorbs1, the ...

    Authors: Alexandra Veloso, Anouk Bleuart, Louise Conrard, Tanguy Orban, Jonathan Bruyr, Pauline Cabochette, Raoul F. V. Germano, Giel Schevenels, Alice Bernard, Egor Zindy, Sofie Demeyer, Benoit Vanhollebeke, Franck Dequiedt and Maud Martin
    Citation: BMC Biology 2024 22:51
    Content type: Research article Published on:

  23. The formation and domestication of ornamental traits are influenced by various aspects, such as the recognition of esthetic values and cultural traditions. Camellia japonica is widely appreciated and domesticated...

    Authors: Zhikang Hu, Zhengqi Fan, Sijia Li, Minyan Wang, Mingchuan Huang, Xianjin Ma, Weixin Liu, Yupeng Wang, Yifan Yu, Yaxuan Li, Yingkun Sun, Xinlei Li, Jiyuan Li and Hengfu Yin
    Citation: BMC Biology 2024 22:50
    Content type: Research article Published on:

    The Author Correction to this article has been published in BMC Biology 2024 22:57

  24. Resolving the phylogeny of rapidly radiating lineages presents a challenge when building the Tree of Life. An Old World avian family Prunellidae (Accentors) comprises twelve species that rapidly diversified at...

    Authors: Zhiyong Jiang, Wenqing Zang, Per G. P. Ericson, Gang Song, Shaoyuan Wu, Shaohong Feng, Sergei V. Drovetski, Gang Liu, Dezhi Zhang, Takema Saitoh, Per Alström, Scott V. Edwards, Fumin Lei and Yanhua Qu
    Citation: BMC Biology 2024 22:49
    Content type: Research article Published on:

  25. Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. De...

    Authors: Andrea Coschiera, Masahito Yoshihara, Gilbert Lauter, Sini Ezer, Mariangela Pucci, Haonan Li, Alan Kavšek, Christian G. Riedel, Juha Kere and Peter Swoboda
    Citation: BMC Biology 2024 22:48
    Content type: Research article Published on:

  26. Crocodilians are one of the oldest extant vertebrate lineages, exhibiting a combination of evolutionary success and morphological resilience that has persisted throughout the history of life on Earth. This abi...

    Authors: Vanessa C. Sales-Oliveira, Rodrigo Zeni dos Santos, Caio Augusto Gomes Goes, Rodrigo Milan Calegari, Manuel A. Garrido-Ramos, Marie Altmanová, Tariq Ezaz, Thomas Liehr, Fabio Porto-Foresti, Ricardo Utsunomia and Marcelo B. Cioffi
    Citation: BMC Biology 2024 22:47
    Content type: Research article Published on:

  27. Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The ass...

    Authors: Troy A. Kervin and Michael Overduin
    Citation: BMC Biology 2024 22:46
    Content type: Opinion Published on:

  28. Most disease resistance (R) genes in plants encode proteins that contain leucine-rich-repeat (LRR) and nucleotide-binding site (NBS) domains, which belong to the NBS-LRR family. The sequenced genomes of Fusarium ...

    Authors: Yunpeng Cao, Wanzhen Mo, Yanli Li, Yao Xiong, Han Wang, Yingjie Zhang, Mengfei Lin, Lin Zhang and Xiaoxu Li
    Citation: BMC Biology 2024 22:45
    Content type: Research article Published on:

  29. Circular RNAs (circRNAs) can regulate microRNA activity and are related to various diseases, such as cancer. Functional research on circRNAs is the focus of scientific research. Accurate identification of circ...

    Authors: Mengting Niu, Chunyu Wang, Yaojia Chen, Quan Zou, Ren Qi and Lei Xu
    Citation: BMC Biology 2024 22:44
    Content type: Research article Published on:

  30. High tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an anti-PD-1, received FDA-approval for the treatment of unresectable/metastatic t...

    Authors: Célia Dupain, Tom Gutman, Elodie Girard, Choumouss Kamoun, Grégoire Marret, Zahra Castel-Ajgal, Marie-Paule Sablin, Cindy Neuzillet, Edith Borcoman, Ségolène Hescot, Céline Callens, Olfa Trabelsi-Grati, Samia Melaabi, Roseline Vibert, Samantha Antonio, Coralie Franck…
    Citation: BMC Biology 2024 22:43
    Content type: Research article Published on:

  31. The adaptive mechanisms of agricultural pests are the key to understanding the evolution of the pests and to developing new control strategies. However, there are few studies on the genetic basis of adaptation...

    Authors: Ping Wang, Minghui Jin, Chao Wu, Yan Peng, Yanjin He, Hanyue Wang and Yutao Xiao
    Citation: BMC Biology 2024 22:42
    Content type: Research article Published on:

  32. Prior to soil formation, phosphate liberated by rock weathering is often sequestered into highly insoluble lanthanide phosphate minerals. Dissolution of these minerals releases phosphate and lanthanides to the...

    Authors: Marcos Y. Voutsinos, Jacob A. West-Roberts, Rohan Sachdeva, John W. Moreau and Jillian F. Banfield
    Citation: BMC Biology 2024 22:41
    Content type: Research article Published on:

  33. Threshold-dependent gene drives (TDGDs) could be used to spread desirable traits through a population, and are likely to be less invasive and easier to control than threshold-independent gene drives. Engineere...

    Authors: Anna Janzen, Ratnasri Pothula, Adam Sychla, Nathan R. Feltman and Michael J. Smanski
    Citation: BMC Biology 2024 22:40
    Content type: Research article Published on:

  34. Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a host, a practice known as surrogacy. The gametes produced by surrogates are often analysed...

    Authors: Rigolin Nayak, Roman Franěk, Audrey Laurent and Martin Pšenička
    Citation: BMC Biology 2024 22:39
    Content type: Research article Published on:

  35. Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these defenses in crops through breeding. However, many crops harbor only a fraction of the g...

    Authors: Noah P. Winters, Eric K. Wafula, Benjamin J. Knollenberg, Tuomas Hämälä, Prakash R. Timilsena, Melanie Perryman, Dapeng Zhang, Lena L. Sheaffer, Craig A. Praul, Paula E. Ralph, Sarah Prewitt, Mariela E. Leandro-Muñoz, Diego A. Delgadillo-Duran, Naomi S. Altman, Peter Tiffin, Siela N. Maximova…
    Citation: BMC Biology 2024 22:38
    Content type: Research article Published on:

  36. In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection...

    Authors: Alfa Dhakal, Chinnu Salim, Mary Skelly, Yarden Amichan, Ayelet T. Lamm and Heather A. Hundley
    Citation: BMC Biology 2024 22:37
    Content type: Research article Published on:

  37. The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointe...

    Authors: S. Öling, E. Struck, M. Noreen-Thorsen, M. Zwahlen, K. von Feilitzen, J. Odeberg, F. Pontén, C. Lindskog, M. Uhlén, P. Dusart and L. M. Butler
    Citation: BMC Biology 2024 22:36
    Content type: Research article Published on:

  38. Social behavior and social organization have major influences on individual health and fitness. Yet, biomedical research focuses on studying a few genotypes under impoverished social conditions. Understanding ...

    Authors: Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett, Caitlin H. Miller, Summer X. Hardy, Matthew K. Arthur, Adam M. Greenstein, Melanie S. Colvin, Lucie M. Michel, Andrew H. Moeller and Michael J. Sheehan
    Citation: BMC Biology 2024 22:35
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Biology 2024 22:72

  39. Viviparity—live birth—is a complex and innovative mode of reproduction that has evolved repeatedly across the vertebrate Tree of Life. Viviparous species exhibit remarkable levels of reproductive diversity, bo...

    Authors: Rhiannon V. Eastment, Bob B. M. Wong and Matthew D. McGee
    Citation: BMC Biology 2024 22:34
    Content type: Research article Published on:

  40. Ribosomal protein SA (RPSA) of human brain microvascular endothelial cells (HBMECs) can transfer from the cytosol to the cell surface and act as a receptor for some pathogens, including Streptococcus suis serotyp...

    Authors: Hexiang Jiang, Yi Sun, Fengyang Li, Xibing Yu, Siyu Lei, Sulan Du, Tong Wu, Xuan Jiang, Junhui Zhu, Jun Wang, Yalu Ji, Na Li, Xin Feng, Jingmin Gu, Wenyu Han, Lei Zeng…
    Citation: BMC Biology 2024 22:33
    Content type: Research article Published on:

  42. The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which cause extreme virulence in chicken and human. ...

    Authors: Jiaxiang Hu, Linfei Song, Mengfei Ning, Xinyu Niu, Mengying Han, Chuze Gao, Xingwei Feng, Han Cai, Te Li, Fangtao Li, Huifang Li, Daoqing Gong, Weitao Song, Long Liu, Juan Pu, Jinhua Liu…
    Citation: BMC Biology 2024 22:31
    Content type: Research article Published on:

  43. Despite the increasing number of epigenomic studies in plants, little is known about the forces that shape the methylome in long-lived woody perennials. The Lombardy poplar offers an ideal opportunity to inves...

    Authors: An Vanden Broeck, Tim Meese, Pieter Verschelde, Karen Cox, Berthold Heinze, Dieter Deforce, Ellen De Meester and Filip Van Nieuwerburgh
    Citation: BMC Biology 2024 22:30
    Content type: Research article Published on:

  44. Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) cha...

    Authors: Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao and Ping Li
    Citation: BMC Biology 2024 22:29
    Content type: Research article Published on:

  45. The human brain can rapidly represent sets of similar stimuli by their ensemble summary statistics, like the average orientation or size. Classic models assume that ensemble statistics are computed by integrat...

    Authors: Natalia A. Tiurina, Yuri A. Markov, David Whitney and David Pascucci
    Citation: BMC Biology 2024 22:28
    Content type: Research article Published on:

  46. Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and me...

    Authors: E. C. Solar Venero, M. B. Galeano, A. Luqman, M. M. Ricardi, F. Serral, D. Fernandez Do Porto, S. A. Robaldi, B. A. Z. Ashari, T. H. Munif, D. E. Egoburo, S. Nemirovsky, J. Escalante, B. Nishimura, M. S. Ramirez, F. Götz and P. M. Tribelli
    Citation: BMC Biology 2024 22:27
    Content type: Research article Published on:

  47. The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of genetically altered knock-in mice via CRISPR-Cas9. ...

    Authors: Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley and Benjamin Davies
    Citation: BMC Biology 2024 22:26
    Content type: Research article Published on:

  48. Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM is so difficult to treat is that it is highly infiltrative. Migrasomes are newly discovered membrane ...

    Authors: Seon Yong Lee, Sang-Hun Choi, Yoonji Kim, Hee-Sung Ahn, Young-Gyu Ko, Kyunggon Kim, Sung Wook Chi and Hyunggee Kim
    Citation: BMC Biology 2024 22:23
    Content type: Research article Published on:

  49. Fungal plant pathogens have dynamic genomes that allow them to rapidly adapt to adverse conditions and overcome host resistance. One way by which this dynamic genome plasticity is expressed is through effector...

    Authors: Alex Z. Zaccaron and Ioannis Stergiopoulos
    Citation: BMC Biology 2024 22:25
    Content type: Research article Published on:

  50. Hematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed to acquire nutrients for reproduction. The midgut epith...

    Authors: M. L. Taracena-Agarwal, B. Hixson, S. Nandakumar, A. P. Girard-Mejia, R. Y. Chen, L. Huot, N. Padilla and N. Buchon
    Citation: BMC Biology 2024 22:22
    Content type: Research article Published on:
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