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  1. Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nu...

    Authors: Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry and Mary Kathryn Sewell-Loftin
    Citation: BMC Biology 2023 21:290
  2. Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotect...

    Authors: Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger and Adam R. Konopka
    Citation: BMC Biology 2023 21:287
  3. Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and agricultural species. Genotyping-by-sequencing, a method which uses low-coverage sequen...

    Authors: H. J. Lamb, L. T. Nguyen, J. P. Copley, B. N. Engle, B. J. Hayes and E. M. Ross
    Citation: BMC Biology 2023 21:286
  4. Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM ...

    Authors: Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang and Ran Huo
    Citation: BMC Biology 2023 21:285
  5. Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remain a conspicuous gap in molecular studies of marine adaptation in vertebrates.

    Authors: Alastair J. Ludington, Jillian M. Hammond, James Breen, Ira W. Deveson and Kate L. Sanders
    Citation: BMC Biology 2023 21:284
  6. Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. These levels of organisation all exist within the same system, with diversity patterns eme...

    Authors: Thomas Keggin, Conor Waldock, Alexander Skeels, Oskar Hagen, Camille Albouy, Stéphanie Manel and Loïc Pellissier
    Citation: BMC Biology 2023 21:282
  7. Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fg...

    Authors: Rheannon O. Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie and Patrick S. Western
    Citation: BMC Biology 2023 21:281
  8. Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal mi...

    Authors: Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang and Weihong Jiang
    Citation: BMC Biology 2023 21:280
  9. The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasites is rarely studied. Divalent metal transporter (DMT1) is a critical iron transporter...

    Authors: Mengjiao Zhong and Bing Zhou
    Citation: BMC Biology 2023 21:279
  10. Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.

    Authors: Madeleine Birgersson, Rajitha Indukuri, Linnéa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer and Cecilia Williams
    Citation: BMC Biology 2023 21:277
  11. Many organisms rely on mineral nutrients taken directly from the soil or aquatic environment, and therefore, developed mechanisms to cope with the limitation of a given essential nutrient. For example, photosy...

    Authors: Stéphanie Bolik, Alexander Schlaich, Tetiana Mukhina, Alberto Amato, Olivier Bastien, Emanuel Schneck, Bruno Demé and Juliette Jouhet
    Citation: BMC Biology 2023 21:275
  12. Aedes aegypti (Ae. aegypti) is the major vector that transmits many diseases including dengue, Zika, and filariasis in tropical and subtropical regions. Due to the growing resistance to chemical-based insecticide...

    Authors: Heng Zhang, Emma Trueman, Xinjun Hou, De Xian Chew, Lu Deng, Jonathan Liew, Tania Chia, Zhiyong Xi, Cheong Huat Tan and Yu Cai
    Citation: BMC Biology 2023 21:274
  13. Sex differences in microRNA (miRNA) expression profiles have been found across multiple tissues. Skeletal muscle is one of the most sex-biased tissues of the body. MiRNAs are necessary for development and have...

    Authors: Danielle Hiam, Shanie Landen, Macsue Jacques, Sarah Voisin, Séverine Lamon and Nir Eynon
    Citation: BMC Biology 2023 21:273
  14. Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While a plethora of studies have connected a significant fraction of human D...

    Authors: Dongyang Xu, Lu Tang, Junjun Zhou, Fang Wang, Huifen Cao, Yu Huang and Philipp Kapranov
    Citation: BMC Biology 2023 21:271
  15. Microbiome analysis is becoming a standard component in many scientific studies, but also requires extensive quality control of the 16S rRNA gene sequencing data prior to analysis. In particular, when investig...

    Authors: Claudia Hülpüsch, Luise Rauer, Thomas Nussbaumer, Vera Schwierzeck, Madhumita Bhattacharyya, Veronika Erhart, Claudia Traidl-Hoffmann, Matthias Reiger and Avidan U. Neumann
    Citation: BMC Biology 2023 21:269
  16. Mayflies are basal winged insects of crucial importance for the understanding of the early evolution of Pterygota. Unlike all other insects, they have two successive winged stages, the subimago and the imago. ...

    Authors: Eduardo Domínguez, Thomas van de Kamp, István Mikó, M. Gabriela Cuezzo and Arnold H. Staniczek
    Citation: BMC Biology 2023 21:268
  17. The red junglefowl, the wild outgroup of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of c...

    Authors: Edward S. Rice, Antton Alberdi, James Alfieri, Giridhar Athrey, Jennifer R. Balacco, Philippe Bardou, Heath Blackmon, Mathieu Charles, Hans H. Cheng, Olivier Fedrigo, Steven R. Fiddaman, Giulio Formenti, Laurent A. F. Frantz, M. Thomas P. Gilbert, Cari J. Hearn, Erich D. Jarvis…
    Citation: BMC Biology 2023 21:267
  18. Unlike most free-living platyhelminths, catenulids, the sister group to all remaining flatworms, do not have eyes. Instead, the most prominent sensory structures in their heads are statocysts or sensory pits. ...

    Authors: Ludwik Gąsiorowski, Isabel Lucia Dittmann, Jeremias N. Brand, Torben Ruhwedel, Wiebke Möbius, Bernhard Egger and Jochen C. Rink
    Citation: BMC Biology 2023 21:266
  19. Lepidoptera is one of the most species-rich animal groups, with substantial karyotype variations among species due to chromosomal rearrangements. Knowledge of the evolutionary patterns of lepidopteran chromoso...

    Authors: Xi Chen, Zuoqi Wang, Chaowei Zhang, Jingheng Hu, Yueqi Lu, Hang Zhou, Yang Mei, Yuyang Cong, Fangyuan Guo, Yaqin Wang, Kang He, Ying Liu and Fei Li
    Citation: BMC Biology 2023 21:265
  20. Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating c...

    Authors: Miao Wang, Bing He, Yueling Hao, Divyaa Srinivasan, Jatin Shrinet and Peter Fraser
    Citation: BMC Biology 2023 21:264
  21. RNA editing by adenosine deaminase acting on RNA (ADAR) occurs in all metazoans and fulfils several functions. Here, we examined effects of acclimation temperature (27 °C, 18 °C,13 °C) on editing patterns in six ...

    Authors: Wenhao Li, Mengdi Bu, Ruiqin Hu, Shouwen Jiang, Liangbiao Chen and George N. Somero
    Citation: BMC Biology 2023 21:262
  22. Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activi...

    Authors: Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis and Thomas Klein
    Citation: BMC Biology 2023 21:260
  23. The endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCS) are extensively studied in aerobic eukaryotes; however, little is known about MCS in anaerobes with reduced forms of mitochondria named ...

    Authors: Jitka Kučerová, Alois Zdrha, Abhishek Shinde, Karel Harant, Ivan Hrdý and Jan Tachezy
    Citation: BMC Biology 2023 21:259
  24. Mutualistic interactions, which constitute some of the most advantageous interactions among fish species, are highly vulnerable to environmental changes. A key mutualistic interaction is the cleaning service r...

    Authors: S. Ramírez-Calero, J. R. Paula, E. Otjacques, T. Ravasi, R. Rosa and C. Schunter
    Citation: BMC Biology 2023 21:258
  25. Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variati...

    Authors: Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang and Martha Constantine-Paton
    Citation: BMC Biology 2023 21:232
  26. Over evolutionary timescales, genomic loci can switch between functional and non-functional states through processes such as pseudogenization and de novo gene birth. Particularly, de novo gene birth is a wides...

    Authors: Somya Mani and Tsvi Tlusty
    Citation: BMC Biology 2023 21:257
  27. Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be inf...

    Authors: Pia Kahnau, Paul Mieske, Jenny Wilzopolski, Otto Kalliokoski, Silvia Mandillo, Sabine M. Hölter, Vootele Voikar, Adriana Amfim, Sylvia Badurek, Aleksandra Bartelik, Angela Caruso, Maša Čater, Elodie Ey, Elisabetta Golini, Anne Jaap, Dragan Hrncic…
    Citation: BMC Biology 2023 21:256
  28. SHANKs are major scaffolding proteins at postsynaptic densities (PSDs) in the central nervous system. Mutations in all three family members have been associated with neurodevelopmental disorders such as autism...

    Authors: Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Schön and Tobias M. Boeckers
    Citation: BMC Biology 2023 21:254
  29. Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecu...

    Authors: Dandan Zhu, Haihong Wang, Wei Wu, Shuaipeng Geng, Guolin Zhong, Yunfei Li, Han Guo, Guanghui Long, Qingqi Ren, Yi Luan, Chaohui Duan, Bing Wei, Jie Ma, Shiyong Li, Jun Zhou and Mao Mao
    Citation: BMC Biology 2023 21:253
  30. Diets high in saturated fat and sugar, termed “Western diets,” have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s disease (PD) is th...

    Authors: Katherine S. Morton, Jessica H. Hartman, Nathan Heffernan, Ian T. Ryde, Isabel W. Kenny-Ganzert, Lingfeng Meng, David R. Sherwood and Joel N. Meyer
    Citation: BMC Biology 2023 21:252
  31. The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene’s DNA copy number. Y...

    Authors: Samuel Hunter, Jo Hendrix, Justin Freeman, Robin D. Dowell and Mary A. Allen
    Citation: BMC Biology 2023 21:228
  32. Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the sco...

    Authors: Tram Anh Nguyen, Jia Wei Joel Heng, Yan Ting Ng, Rui Sun, Shira Fisher, Gokce Oguz, Pornchai Kaewsapsak, Shifeng Xue, Bruno Reversade, Adaikalavan Ramasamy, Eli Eisenberg and Meng How Tan
    Citation: BMC Biology 2023 21:251
  33. Nme2ABE8e has been constructed and characterized as a compact, accurate adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM: N4CC) but low editing efficiency at challenging...

    Authors: Ding Zhao, Xun Gao, Jiale Zhou, Jinze Li, Yuqiang Qian, Di Wang, Wenchao Niu, Tao Zhang, Mingyang Hu, Haoyang Xiong, Liangxue Lai and Zhanjun Li
    Citation: BMC Biology 2023 21:250
  34. Shifts in dynamic equilibria of the abundance of cellular molecules in plant-pathogen interactions need further exploration. We induced PTI in optimally growing Arabidopsis thaliana seedlings for 16 h, returning ...

    Authors: Mohammad Abukhalaf, Carsten Proksch, Domenika Thieme, Jörg Ziegler and Wolfgang Hoehenwarter
    Citation: BMC Biology 2023 21:249
  35. Open-top light-sheet microscopy (OT-LSM) is a specialized microscopic technique for the high-throughput cellular imaging of optically cleared, large-sized specimens, such as the brain. Despite the development ...

    Authors: Soohyun Park, Myeongsu Na, Sunghoe Chang and Ki Hean Kim
    Citation: BMC Biology 2023 21:248
  36. Leptosphaeria maculans “brassicae” (Lmb) and Leptosphaeria biglobosa “brassicae” (Lbb) make up a species complex involved in the stem canker (blackleg) disease of rapeseed (Brassica napus). They coinfect rapeseed...

    Authors: Elise J. Gay, Noémie Jacques, Nicolas Lapalu, Corinne Cruaud, Valerie Laval, Marie-Hélène Balesdent and Thierry Rouxel
    Citation: BMC Biology 2023 21:247
  37. The exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay (NMD). It is assembled by the splicing machinery onto mRNA in a sequence-...

    Authors: Lucía Morillo, Toni Paternina, Quentin Alasseur, Auguste Genovesio, Schraga Schwartz and Hervé Le Hir
    Citation: BMC Biology 2023 21:246
  38. Sterile-fertile heteroblasty is a common phenomenon observed in ferns, where the leaf shape of a fern sporophyll, responsible for sporangium production, differs from that of a regular trophophyll. However, due...

    Authors: Yue Zhang, Yves Van de Peer, Bei Lu, Sisi Zhang, Jingru Che, Jinming Chen, Kathleen Marchal and Xingyu Yang
    Citation: BMC Biology 2023 21:244
  39. Epigenetic modifications that exhibit circadian oscillations also promote circadian oscillations of gene expression. Brassica napus is a heterozygous polyploid species that has undergone distant hybridization and...

    Authors: Zhifei Xue, Baibai Gao, Guoting Chen, Jie Liu, Weizhi Ouyang, Mohamed Frahat Foda, Qing Zhang, Xiwen Zhang, Wei Zhang, Mingyue Guo, Xingwang Li and Bin Yi
    Citation: BMC Biology 2023 21:241
  40. PFTK1/Eip63E is a member of the cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E expresses primarily in postnatal and adult nervous system in Drosophila ...

    Authors: Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul R. Albert, David S. Park and Alvin Joselin
    Citation: BMC Biology 2023 21:240
  41. Melanin plays important roles in morphological development, survival, host–pathogen interactions and in the virulence of phytopathogenic fungi. In Verticillum dahliae, increases in melanin are recognized as marke...

    Authors: Huan Li, Ruo-Cheng Sheng, Chen-Ning Zhang, Li-Chao Wang, Min Li, Ya-Hong Wang, Yu-Hang Qiao, Steven J. Klosterman, Jie-Yin Chen, Zhi-Qiang Kong, Krishna V. Subbarao, Feng-Mao Chen and Dan-Dan Zhang
    Citation: BMC Biology 2023 21:237
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