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  1. The SARS-CoV-2/COVID-19 pandemic has inflicted medical and socioeconomic havoc, and despite the current availability of vaccines and broad implementation of vaccination programs, more easily accessible and cos...

    Authors: Vu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Roman Sakson, Julia K. Lill, Siva Swapna Kasarla, Dominik Kopczynski, Stefan Loroch, Yulia Flores-Martinez, Benjamin Katschinski, Kerstin Wohlgemuth, Matthias Gunzer, Folker Meyer, Prasad Phapale, Ulf Dittmer, Albert Sickmann…
    Citation: BMC Biology 2022 20:264
  2. Deep-learning–based image segmentation models are required for accurate processing of high-throughput timelapse imaging data of bacterial cells. However, the performance of any such model strictly depends on t...

    Authors: Georgeos Hardo, Maximilian Noka and Somenath Bakshi
    Citation: BMC Biology 2022 20:263
  3. During range expansion in spatially distributed habitats, organisms differ from one another in terms of their patterns of localization versus propagation. To exploit locations or explore the landscape? This is...

    Authors: Miles T. Wetherington, Krisztina Nagy, László Dér, Ágnes Ábrahám, Janneke Noorlag, Peter Galajda and Juan E. Keymer
    Citation: BMC Biology 2022 20:262
  4. Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular fola...

    Authors: Xiguang Xu, Zachary Johnson, Amanda Wang, Rachel L. Padget, James W. Smyth and Hehuang Xie
    Citation: BMC Biology 2022 20:261
  5. One of the ways genomes respond to stress is by producing extrachromosomal circular DNAs (eccDNAs). EccDNAs can contain genes and dramatically increase their copy number. They can also reinsert into the genome...

    Authors: Pierre M. Joubert and Ksenia V. Krasileva
    Citation: BMC Biology 2022 20:260
  6. Satellite DNAs (satDNAs) are tandemly repeated non-coding DNA sequences that belong to the most abundant and the fastest evolving parts of the eukaryotic genome. A satellitome represents the collection of diff...

    Authors: Evelin Despot-Slade, Saša Širca, Brankica Mravinac, Philippe Castagnone-Sereno, Miroslav Plohl and Nevenka Meštrović
    Citation: BMC Biology 2022 20:259
  7. Commensal microorganisms have a significant impact on the physiology of host animals, including Drosophila. Lactobacillus and Acetobacter, the two most common commensal bacteria in Drosophila, stimulate fly devel...

    Authors: Jaegeun Lee, Hyun Myoung Yun, Gangsik Han, Gang Jun Lee, Che Ok Jeon and Seogang Hyun
    Citation: BMC Biology 2022 20:258
  8. RNA G-quadruplexes (rG4s) are non-canonical structural motifs that have diverse functional and regulatory roles, for instance in transcription termination, alternative splicing, mRNA localization and stabiliza...

    Authors: Jieyu Zhao, Eugene Yui-Ching Chow, Pui Yan Yeung, Qiangfeng Cliff Zhang, Ting-Fung Chan and Chun Kit Kwok
    Citation: BMC Biology 2022 20:257
  9. Plants are continuously challenged with biotic stress from environmental pathogens, and precise regulation of defense responses is critical for plant survival. Defense systems require considerable amounts of e...

    Authors: Qin Zhou, Yingnan Sun, Xiwang Zhao, Yue Yu, Weijia Cheng, Li Lu, Zhaohui Chu and Xiangsong Chen
    Citation: BMC Biology 2022 20:256
  10. Combinatorial gene regulation by multiple microRNAs (miRNAs) is widespread and closely spaced target sites often act cooperatively to achieve stronger repression (“neighborhood” miRNA cotargeting). While miRNA...

    Authors: Hiroki Kitai, Noritoshi Kato, Koichi Ogami, Shintaro Komatsu, Yu Watanabe, Seiko Yoshino, Eri Koshi, Shoma Tsubota, Yoshio Funahashi, Takahiro Maeda, Kazuhiro Furuhashi, Takuji Ishimoto, Tomoki Kosugi, Shoichi Maruyama, Kenji Kadomatsu and Hiroshi I. Suzuki
    Citation: BMC Biology 2022 20:248
  11. To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain wate...

    Authors: Li-Ming Hsu, Jen-Tsung Yang, Xuyun Wen, Xia Liang, Leng-Chieh Lin, Yen-Chu Huang and Yuan-Hsiung Tsai
    Citation: BMC Biology 2022 20:255
  12. Heat stress is a major abiotic stress affecting the growth and development of plants, including crop species. Plants have evolved various adaptive strategies to help them survive heat stress, including maintai...

    Authors: Xia Chen, Huidan Xue, Liping Zhu, Huiqin Wang, Hao Long, Jun Zhao, Funing Meng, Yunfei Liu, Yuan Ye, Xiaomin Luo, Zhi Liu, Guanghui Xiao and Shengwei Zhu
    Citation: BMC Biology 2022 20:254
  13. Schema, a concept from cognitive psychology used to explain how new information is integrated with previous experience, is a framework of acquired knowledge within associative network structures as biological ...

    Authors: Shu Liu, Heung Yan Wong, Li Xie, Zafar Iqbal, Zhuogui Lei, Zhongqi Fu, Yuk Yan Lam, Aruna Surendran Ramkrishnan and Ying Li
    Citation: BMC Biology 2022 20:250
  14. Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a pheno...

    Authors: Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch and Liesbet Geris
    Citation: BMC Biology 2022 20:253
  15. Symbiotic associations between bacteria and leguminous plants lead to the formation of root nodules that fix nitrogen needed for sustainable agricultural systems. Symbiosis triggers extensive genome and transc...

    Authors: Sara A. Knaack, Daniel Conde, Sanhita Chakraborty, Kelly M. Balmant, Thomas B. Irving, Lucas Gontijo Silva Maia, Paolo M. Triozzi, Christopher Dervinis, Wendell J. Pereira, Junko Maeda, Henry W. Schmidt, Jean-Michel Ané, Matias Kirst and Sushmita Roy
    Citation: BMC Biology 2022 20:252
  16. Nocardia is a facultative intracellular pathogen that infects the lungs and brains of immunocompromised patients with consequences that can be fatal. The incidence of such infections is rising, immunocompetent in...

    Authors: Xingzhao Ji, Lichao Han, Weiying Zhang, Lina Sun, Shuai Xu, Xiaotong Qiu, Shihong Fan and Zhenjun Li
    Citation: BMC Biology 2022 20:251
  17. The Nile rat (Avicanthis niloticus) is an important animal model because of its robust diurnal rhythm, a cone-rich retina, and a propensity to develop diet-induced diabetes without chemical or genetic modificatio...

    Authors: Huishi Toh, Chentao Yang, Giulio Formenti, Kalpana Raja, Lily Yan, Alan Tracey, William Chow, Kerstin Howe, Lucie A. Bergeron, Guojie Zhang, Bettina Haase, Jacquelyn Mountcastle, Olivier Fedrigo, John Fogg, Bogdan Kirilenko, Chetan Munegowda…
    Citation: BMC Biology 2022 20:245
  18. Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introg...

    Authors: Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci and Renato Polimanti
    Citation: BMC Biology 2022 20:249
  19. Scab, caused by the biotrophic fungus Venturia inaequalis, is the most economically important disease of apples worldwide. During infection, V. inaequalis occupies the subcuticular environment, where it secretes ...

    Authors: Mercedes Rocafort, Joanna K. Bowen, Berit Hassing, Murray P. Cox, Brogan McGreal, Silvia de la Rosa, Kim M. Plummer, Rosie E. Bradshaw and Carl H. Mesarich
    Citation: BMC Biology 2022 20:246
  20. Animals can exhibit remarkable reproductive plasticity in response  to their social surroundings, with profound fitness consequences. The presence of same-sex conspecifics can signal current or future expected...

    Authors: E. K. Fowler, S. Leigh, W. G. Rostant, A. Thomas, A. Bretman and T. Chapman
    Citation: BMC Biology 2022 20:244
  21. Transposable elements (TEs) have been likened to parasites in the genome that reproduce and move ceaselessly in the host, continuously enlarging the host genome. However, the Piwi-interacting RNA (piRNA) pathw...

    Authors: Xuanzeng Liu, Muhammad Majid, Hao Yuan, Huihui Chang, Lina Zhao, Yimeng Nie, Lang He, Xiaojing Liu, Xiaoting He and Yuan Huang
    Citation: BMC Biology 2022 20:243
  22. Adaptive laboratory evolution (ALE) is a powerful method for strain optimization towards abiotic stress factors and for identifying adaptation mechanisms. In this study, the green microalga Picochlorum sp. BPE23 ...

    Authors: Robin Barten, Dirk-Jan M. van Workum, Emma de Bakker, Judith Risse, Michelle Kleisman, Sofia Navalho, Sandra Smit, Rene H. Wijffels, Harm Nijveen and Maria J. Barbosa
    Citation: BMC Biology 2022 20:242
  23. Circadian clocks occur across the kingdoms of life, including some fungi and bacteria present in the root-associated soil known as the rhizosphere. Recent work from Amy Newman and colleagues, published in BMC ...

    Authors: Xinming Xu and Antony N. Dodd
    Citation: BMC Biology 2022 20:241

    The original article was published in BMC Biology 2022 20:235

  24. The centrosome is one of the most important non-membranous organelles regulating microtubule organization and progression of cell mitosis. The coiled-coil alpha-helical rod protein 1 (CCHCR1, also known as HCR...

    Authors: Zhenguang Ying, Kaifang Wang, Junfeng Wu, Mingyu Wang, Jing Yang, Xia Wang, Guowei Zhou, Haibin Chen, Hongwu Xu, Stephen Cho Wing Sze, Feng Gao, Chunman Li and Ou Sha
    Citation: BMC Biology 2022 20:240
  25. In fungal plant pathogens, genome rearrangements followed by selection pressure for adaptive traits have facilitated the co-evolutionary arms race between hosts and their pathogens. Pyrenophora tritici-repentis (...

    Authors: Ryan Gourlie, Megan McDonald, Mohamed Hafez, Rodrigo Ortega-Polo, Kristin E. Low, D. Wade Abbott, Stephen E. Strelkov, Fouad Daayf and Reem Aboukhaddour
    Citation: BMC Biology 2022 20:239
  26. By 2016, signs of emergence of Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently, the independent evolution of artemisinin resistance has al...

    Authors: Inés Bouzón-Arnáiz, Yunuen Avalos-Padilla, Arnau Biosca, Omar Caño-Prades, Lucía Román-Álamo, Javier Valle, David Andreu, Diana Moita, Miguel Prudêncio, Elsa M. Arce, Diego Muñoz-Torrero and Xavier Fernàndez-Busquets
    Citation: BMC Biology 2022 20:197
  27. Lipid homeostasis is an evolutionarily conserved process that is crucial for energy production, storage and consumption. Drosophila larvae feed continuously to achieve the roughly 200-fold increase in size and ac...

    Authors: Magdalena Fernandez-Acosta, Juan I. Romero, Guillermo Bernabó, Giovanna M. Velázquez-Campos, Nerina Gonzalez, M. Lucía Mares, Santiago Werbajh, L. Amaranta Avendaño-Vázquez, Gerald N. Rechberger, Ronald P. Kühnlein, Cristina Marino-Buslje, Rafael Cantera, Carolina Rezaval and M. Fernanda Ceriani
    Citation: BMC Biology 2022 20:233
  28. Authors: Sergio E. Palma-Vera, Henry Reyer, Martina Langhammer, Norbert Reinsch, Lorena Derezanin, Joerns Fickel, Saber Qanbari, Joachim M. Weitzel, Soeren Franzenburg, Georg Hemmrich-Stanisak and Jennifer Schoen
    Citation: BMC Biology 2022 20:238

    The original article was published in BMC Biology 2022 20:52

  29. Authors: Jenifer Vallejo, Ryosuke Saigusa, Rishab Gulati, Sujit Silas Armstrong Suthahar, Vasantika Suryawanshi, Ahmad Alimadadi, Christopher P. Durant, Yanal Ghosheh, Payel Roy, Erik Ehinger, Tanyaporn Pattarabanjird, David B. Hanna, Alan L. Landay, Russell P. Tracy, Jason M. Lazar, Wendy J. Mack…
    Citation: BMC Biology 2022 20:237

    The original article was published in BMC Biology 2022 20:193

  30. The Fusarium solani species complex (FSSC) comprises fungal pathogens responsible for mortality in a diverse range of animals and plants, but their genome diversity and transcriptome responses in animal pathogeni...

    Authors: Daphne Z. Hoh, Hsin-Han Lee, Naohisa Wada, Wei-An Liu, Min R. Lu, Cheng-Kuo Lai, Huei-Mien Ke, Pei-Feng Sun, Sen-Lin Tang, Wen-Hsin Chung, Ying-Lien Chen, Chia-Lin Chung and Isheng Jason Tsai
    Citation: BMC Biology 2022 20:236
  31. Recent studies demonstrated that microbiota inhabiting the plant rhizosphere exhibit diel changes in abundance. To investigate the impact of plant circadian rhythms on bacterial and fungal rhythms in the rhizo...

    Authors: Amy Newman, Emma Picot, Sian Davies, Sally Hilton, Isabelle A. Carré and Gary D. Bending
    Citation: BMC Biology 2022 20:235

    The Commentary to this article has been published in BMC Biology 2022 20:241

  32. Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in ro...

    Authors: Rebecca Z. Weber, Geertje Mulders, Julia Kaiser, Christian Tackenberg and Ruslan Rust
    Citation: BMC Biology 2022 20:232
  33. Antarctica harbors the bulk of the species diversity of the dominant teleost fish suborder—Notothenioidei. However, the forces that shape their evolution are still under debate.

    Authors: Ying Lu, Wenhao Li, Yalin Li, Wanying Zhai, Xuming Zhou, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu, Adelino V. M. Canário…
    Citation: BMC Biology 2022 20:231
  34. The nose of most animals comprises multiple sensory subsystems, which are defined by the expression of different olfactory receptor families. Drosophila melanogaster antennae contain two morphologically and funct...

    Authors: Marta Scalzotto, Renny Ng, Steeve Cruchet, Michael Saina, Jan Armida, Chih-Ying Su and Richard Benton
    Citation: BMC Biology 2022 20:230
  35. One-carbon metabolism, which includes the folate and methionine cycles, involves the transfer of methyl groups which are then utilised as a part of multiple physiological processes including redox defence. Dur...

    Authors: Alan D. Winter, Elissa Tjahjono, Leonardo J. Beltrán, Iain L. Johnstone, Neil J. Bulleid and Antony P. Page
    Citation: BMC Biology 2022 20:228
  36. Cryptophytes are ecologically important algae of interest to evolutionary cell biologists because of the convoluted history of their plastids and nucleomorphs, which are derived from red algal secondary endosy...

    Authors: Jong Im Kim, Goro Tanifuji, Minseok Jeong, Woongghi Shin and John M. Archibald
    Citation: BMC Biology 2022 20:227
  37. Candida glabrata is an opportunistic yeast pathogen thought to have a large genetic and phenotypic diversity and a highly plastic genome. However, the lack of chromosome-level genome assemblies representing this...

    Authors: Marina Marcet-Houben, María Alvarado, Ewa Ksiezopolska, Ester Saus, Piet W. J. de Groot and Toni Gabaldón
    Citation: BMC Biology 2022 20:226
  38. Shotgun metagenomic sequencing has greatly expanded the understanding of microbial communities in various biological niches. However, it is still challenging to efficiently convert sub-nanogram DNA to high-qua...

    Authors: Chun Wang, Li Zhang, Xuan Jiang, Wentai Ma, Hui Geng, Xue Wang and Mingkun Li
    Citation: BMC Biology 2022 20:225
  39. Fungi produce a wide range of specialized metabolites (SMs) involved in biotic interactions. Pathways for the production of SMs are often encoded in clusters of tightly arranged genes identified as biosyntheti...

    Authors: Nikhil Kumar Singh, Sabina Moser Tralamazza, Leen Nanchira Abraham, Gaétan Glauser and Daniel Croll
    Citation: BMC Biology 2022 20:224
  40. The process of early development varies across the species-rich phylum Arthropoda. Owing to the limited research strategies for dissecting lineage-specific processes of development in arthropods, little is kno...

    Authors: Sawa Iwasaki-Yokozawa, Ryota Nanjo, Yasuko Akiyama-Oda and Hiroki Oda
    Citation: BMC Biology 2022 20:223
  41. Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and ...

    Authors: Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li and Valerie C. L. Lin
    Citation: BMC Biology 2022 20:222
  42. Feature-based attention prioritizes the processing of the attended feature while strongly suppressing the processing of nearby ones. This creates a non-linearity or “attentional suppressive surround” predicted...

    Authors: Sang-Ah Yoo, Julio C. Martinez-Trujillo, Stefan Treue, John K. Tsotsos and Mazyar Fallah
    Citation: BMC Biology 2022 20:220
  43. Hypoxia naturally happens in embryogenesis and thus serves as an important environmental factor affecting embryo development. Hif-1α, an essential hypoxia response factor, was mostly considered to mediate or s...

    Authors: Xiaopeng Shen, Meng Li, Chunguang Wang, Zhongxian Liu, Kun Wu, Ao Wang, Chao Bi, Shan Lu, Hongan Long and Guoping Zhu
    Citation: BMC Biology 2022 20:219
  44. Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such a...

    Authors: Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali and Denis Vivien
    Citation: BMC Biology 2022 20:218
  45. Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerizatio...

    Authors: Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet and Isabelle M. L. Billas
    Citation: BMC Biology 2022 20:217
  46. Eudicots are the most diverse group of flowering plants that compromise five well-defined lineages: core eudicots, Ranunculales, Proteales, Trochodendrales, and Buxales. However, the phylogenetic relationships...

    Authors: Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu and Yongzhi Yang
    Citation: BMC Biology 2022 20:216