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  1. Content type: Research article

    The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making...

    Authors: Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun and Brett Nixon

    Citation: BMC Biology 2019 17:35

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  2. Content type: Research article

    Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation ...

    Authors: Liliane Abuin, Lucia L. Prieto-Godino, Haiyun Pan, Craig Gutierrez, Lan Huang, Rongsheng Jin and Richard Benton

    Citation: BMC Biology 2019 17:34

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  3. Content type: Research article

    Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiolo...

    Authors: Lawrance Chandra, Dana C. Borcherding, Dawn Kingsbury, Todd Atherly, Yoko M. Ambrosini, Agnes Bourgois-Mochel, Wang Yuan, Michael Kimber, Yijun Qi, Qun Wang, Michael Wannemuehler, N. Matthew Ellinwood, Elizabeth Snella, Martin Martin, Melissa Skala, David Meyerholz…

    Citation: BMC Biology 2019 17:33

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  4. Content type: Research article

    Epigenetic mechanisms play fundamental roles in brain function and behavior and stressors such as social isolation can alter animal behavior via epigenetic mechanisms. However, due to cellular heterogeneity, i...

    Authors: Pavan Agrawal, Phuong Chung, Ulrike Heberlein and Clement Kent

    Citation: BMC Biology 2019 17:30

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  5. Content type: Research article

    Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as...

    Authors: Vanessa R. Marcelino, Michelle Wille, Aeron C. Hurt, Daniel González-Acuña, Marcel Klaassen, Timothy E. Schlub, John-Sebastian Eden, Mang Shi, Jonathan R. Iredell, Tania C. Sorrell and Edward C. Holmes

    Citation: BMC Biology 2019 17:31

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  6. Content type: Research article

    The processing of optic flow in the pretectum/accessory optic system allows animals to stabilize retinal images by executing compensatory optokinetic and optomotor behavior. The success of this behavior depend...

    Authors: Kun Wang, Julian Hinz, Väinö Haikala, Dierk F. Reiff and Aristides B. Arrenberg

    Citation: BMC Biology 2019 17:29

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  7. Content type: Research article

    Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The...

    Authors: Hak-Min Kim, Jessica A. Weber, Nayoung Lee, Seung Gu Park, Yun Sung Cho, Youngjune Bhak, Nayun Lee, Yeonsu Jeon, Sungwon Jeon, Victor Luria, Amir Karger, Marc W. Kirschner, Ye Jin Jo, Seonock Woo, Kyoungsoon Shin, Oksung Chung…

    Citation: BMC Biology 2019 17:28

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  8. Content type: Comment

    Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journa...

    Authors: Michael P. Milham and Arno Klein

    Citation: BMC Biology 2019 17:27

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  9. Content type: Correction

    Upon publication of the original article [1], the authors noticed that they omitted Additional file 16: Table S10 from the Additional file list. Additional file 16: Table S10 can be found attached to this Corr...

    Authors: Zhibo Cui, Aizi Tong, Yiqiong Huo, Zhiqiang Yan, Wenqi Yang, Xianli Yang and Xiao-Xue Wang

    Citation: BMC Biology 2019 17:25

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    The original article was published in BMC Biology 2017 15:80

  10. Content type: Research article

    The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and...

    Authors: Basten L. Snoek, Rita J. M. Volkers, Harm Nijveen, Carola Petersen, Philipp Dirksen, Mark G. Sterken, Rania Nakad, Joost A. G. Riksen, Philip Rosenstiel, Jana J. Stastna, Bart P. Braeckman, Simon C. Harvey, Hinrich Schulenburg and Jan E. Kammenga

    Citation: BMC Biology 2019 17:24

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  11. Content type: Research article

    Female mammals have a limited reproductive lifespan determined by the size of the primordial follicle pool established perinatally. Over two thirds of fetal oocytes are abolished via programmed cell death duri...

    Authors: Jia Wen, Hao Yan, Meina He, Tuo Zhang, Xinyi Mu, Haibin Wang, Hua Zhang, Guoliang Xia and Chao Wang

    Citation: BMC Biology 2019 17:23

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  12. Content type: Research article

    Although the overall brain organization is shared in vertebrates, there are significant differences within subregions among different groups, notably between Sarcopterygii (lobe-finned fish) and Actinopterygii...

    Authors: Solal Bloch, Manon Thomas, Ingrid Colin, Sonya Galant, Elodie Machado, Pierre Affaticati, Arnim Jenett and Kei Yamamoto

    Citation: BMC Biology 2019 17:22

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  13. Content type: Research article

    Microbial communities are susceptible to the public goods dilemma, whereby individuals can gain an advantage within a group by utilizing, but not sharing the cost of producing, public goods. In bacteria, the d...

    Authors: Kelei Zhao, Linjie Liu, Xiaojie Chen, Ting Huang, Lianming Du, Jiafu Lin, Yang Yuan, Yingshun Zhou, Bisong Yue, Kun Wei and Yiwen Chu

    Citation: BMC Biology 2019 17:20

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  14. Content type: Research article

    Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species ca...

    Authors: Courtney W. Stairs, Anna Kokla, Ásgeir Ástvaldsson, Jon Jerlström-Hultqvist, Staffan Svärd and Thijs J. G. Ettema

    Citation: BMC Biology 2019 17:19

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  15. Content type: Research article

    Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelm...

    Authors: Antony P. Page, Mark Roberts, Marie-Anne Félix, Derek Pickard, Andrew Page and William Weir

    Citation: BMC Biology 2019 17:10

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  16. Content type: Question and Answer

    Farmers around the world have recently experienced significant crop losses due to severe heat and drought. Such extreme weather events and the need to feed a rapidly growing population have raised concerns for...

    Authors: Kai P. Voss-Fels, Andreas Stahl and Lee T. Hickey

    Citation: BMC Biology 2019 17:18

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  17. Content type: Comment

    Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shape...

    Authors: Timothy E. Saunders and Philip W. Ingham

    Citation: BMC Biology 2019 17:17

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  18. Content type: Research article

    Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminth...

    Authors: Gregory A. Cary, Andrew Wolff, Olga Zueva, Joseph Pattinato and Veronica F. Hinman

    Citation: BMC Biology 2019 17:16

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  19. Content type: Commentary

    A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 tha...

    Authors: Nicholas J. Gay

    Citation: BMC Biology 2019 17:15

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    The original article was published in BMC Biology 2018 16:149

  20. Content type: Research article

    Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in...

    Authors: Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P. Ponting, Eric A. Miska and Wilfried Haerty

    Citation: BMC Biology 2019 17:14

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  21. Content type: Research article

    Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition. Unli...

    Authors: Ginger L. Hunter, Li He, Norbert Perrimon, Guillaume Charras, Edward Giniger and Buzz Baum

    Citation: BMC Biology 2019 17:12

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  22. Content type: Research article

    Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gr...

    Authors: ThankGod E. Ebenezer, Martin Zoltner, Alana Burrell, Anna Nenarokova, Anna M. G. Novák Vanclová, Binod Prasad, Petr Soukal, Carlos Santana-Molina, Ellis O’Neill, Nerissa N. Nankissoor, Nithya Vadakedath, Viktor Daiker, Samson Obado, Sara Silva-Pereira, Andrew P. Jackson, Damien P. Devos…

    Citation: BMC Biology 2019 17:11

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  23. Content type: Research article

    CRISPR-Cas12a (formerly Cpf1) is an RNA-guided endonuclease with distinct features that have expanded genome editing capabilities. Cas12a-mediated genome editing is temperature sensitive in plants, but a lack ...

    Authors: Aimee A. Malzahn, Xu Tang, Keunsub Lee, Qiurong Ren, Simon Sretenovic, Yingxiao Zhang, Hongqiao Chen, Minjeong Kang, Yu Bao, Xuelian Zheng, Kejun Deng, Tao Zhang, Valeria Salcedo, Kan Wang, Yong Zhang and Yiping Qi

    Citation: BMC Biology 2019 17:9

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  24. Content type: Research article

    In socially monogamous species, reproduction is not always confined to paired males and females. Extra-pair males commonly also reproduce with paired females, which is traditionally thought to be costly to the...

    Authors: Aneesh P. H. Bose, Jonathan M. Henshaw, Holger Zimmermann, Karoline Fritzsche and Kristina M. Sefc

    Citation: BMC Biology 2019 17:2

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  25. Content type: Review

    Photosynthesis and nitrogen fixation became evolutionarily immutable as “frozen metabolic accidents” because multiple interactions between the proteins and protein complexes involved led to their co-evolution ...

    Authors: Dario Leister

    Citation: BMC Biology 2019 17:8

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  26. Content type: Research article

    The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), especially those that are multidrug resistant poses a serious threat to global tuberculosis control. However, the mechanism underlying ...

    Authors: Lianhua Qin, Jie Wang, Junmei Lu, Hua Yang, Ruijuan Zheng, Zhonghua Liu, Xiaochen Huang, Yonghong Feng, Zhongyi Hu and Baoxue Ge

    Citation: BMC Biology 2019 17:7

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  27. Content type: Research article

    Sex determination mechanisms in teleost fish broadly differ from mammals and birds, with sex chromosomes that are far less differentiated and recombination often occurring along the length of the X and Y chrom...

    Authors: Lisui Bao, Changxu Tian, Shikai Liu, Yu Zhang, Ahmed Elaswad, Zihao Yuan, Karim Khalil, Fanyue Sun, Yujia Yang, Tao Zhou, Ning Li, Suxu Tan, Qifan Zeng, Yang Liu, Yueru Li, Yun Li…

    Citation: BMC Biology 2019 17:6

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  28. Content type: Research article

    RNA localization involves cis-motifs that are recognized by RNA-binding proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA localization is critical for many different ce...

    Authors: Sarah A. Middleton, James Eberwine and Junhyong Kim

    Citation: BMC Biology 2019 17:5

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  29. Content type: Research article

    Recent genome studies of modern and ancient samples have proposed that Native Americans derive from a subset of the Eurasian gene pool carried to America by an ancestral Beringian population, from which two we...

    Authors: Viola Grugni, Alessandro Raveane, Linda Ongaro, Vincenza Battaglia, Beniamino Trombetta, Giulia Colombo, Marco Rosario Capodiferro, Anna Olivieri, Alessandro Achilli, Ugo A. Perego, Jorge Motta, Maribel Tribaldos, Scott R. Woodward, Luca Ferretti, Fulvio Cruciani, Antonio Torroni…

    Citation: BMC Biology 2019 17:3

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  30. Content type: Research article

    Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regula...

    Authors: Alba Carreras, Luna Simona Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz M. Mayr, Rosie Perkins…

    Citation: BMC Biology 2019 17:4

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  31. Content type: Methodology article

    Current mesoscale 3D imaging techniques are limited to transparent or cleared samples or require the use of X-rays. This is a severe limitation for many research areas, as the 3D color surface morphology of op...

    Authors: Axelle Kerstens, Nikky Corthout, Benjamin Pavie, Zengjin Huang, Frank Vernaillen, Greetje Vande Velde and Sebastian Munck

    Citation: BMC Biology 2019 17:1

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  32. Content type: Methodology article

    Cultured human cells are pivotal models to study human gene functions, but introducing complete loss of function in diploid or aneuploid cells has been a challenge. The recently developed CRISPR/Cas9-mediated ...

    Authors: Chenzi Zhang, Xiangjun He, Yvonne K. Kwok, Feng Wang, Junyi Xue, Hui Zhao, Kin Wah Suen, Chi Chiu Wang, Jianwei Ren, George G. Chen, Paul B. S. Lai, Jiangchao Li, Yin Xia, Andrew M. Chan, Wai-Yee Chan and Bo Feng

    Citation: BMC Biology 2018 16:151

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  33. Content type: Methodology article

    Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the eff...

    Authors: Matthew A. Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta, Jonathan D. Wrigley, Maria Emanuela Cuomo, Marcello Maresca and Benjamin J. M. Taylor

    Citation: BMC Biology 2018 16:150

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  34. Content type: Research article

    Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recog...

    Authors: Ailís O’Carroll, Brieuc Chauvin, James W. P. Brown, Ava Meagher, Joanne Coyle, Jurgen Schill, Akshay Bhumkhar, Dominic J. B. Hunter, Thomas Ve, Bostjan Kobe, Emma Sierecki and Yann Gambin

    Citation: BMC Biology 2018 16:149

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    The Commentary to this article has been published in BMC Biology 2019 17:15

  35. Content type: Research article

    Many physiological processes in our body are controlled by the biological clock and show circadian rhythmicity. It is generally accepted that a robust rhythm is a prerequisite for optimal functioning and that ...

    Authors: Christian Tudorache, Hans Slabbekoorn, Yuri Robbers, Eline Hin, Johanna H. Meijer, Herman P. Spaink and Marcel J. M. Schaaf

    Citation: BMC Biology 2018 16:148

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  36. Content type: Research article

    The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studie...

    Authors: Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell and Jeremy M. Van Raamsdonk

    Citation: BMC Biology 2018 16:147

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  37. Content type: Research article

    Increases in biological complexity and the origins of life’s hierarchical organization are described by the “major transitions” framework. A crucial component of this paradigm is that after the transition in c...

    Authors: Matthew D. Herron, Seyed A. Zamani-Dahaj and William C. Ratcliff

    Citation: BMC Biology 2018 16:145

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  38. Content type: Research article

    The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. rein...

    Authors: Yuehui Tian, Shiqiang Gao, Eva Laura von der Heyde, Armin Hallmann and Georg Nagel

    Citation: BMC Biology 2018 16:144

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  39. Content type: Research article

    Activity in populations of neurons often takes the form of assemblies, where specific groups of neurons tend to activate at the same time. However, in calcium imaging data, reliably identifying these assemblie...

    Authors: Jan Mölter, Lilach Avitan and Geoffrey J. Goodhill

    Citation: BMC Biology 2018 16:143

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    The Correction to this article has been published in BMC Biology 2019 17:21

  40. Content type: Commentary

    The capture and enslavement of eukaryotic algae by unicellular predators to acquire photosynthesis was a major driving force in early eukaryotic diversification. A genome presented in BMC Biology provides a glimp...

    Authors: Geoffrey Ian McFadden

    Citation: BMC Biology 2018 16:140

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    The original article was published in BMC Biology 2018 16:137

  41. Content type: Research article

    The evolution of photosynthesis has been a major driver in eukaryotic diversification. Eukaryotes have acquired plastids (chloroplasts) either directly via the engulfment and integration of a photosynthetic cy...

    Authors: Ugo Cenci, Shannon J. Sibbald, Bruce A. Curtis, Ryoma Kamikawa, Laura Eme, Daniel Moog, Bernard Henrissat, Eric Maréchal, Malika Chabi, Christophe Djemiel, Andrew J. Roger, Eunsoo Kim and John M. Archibald

    Citation: BMC Biology 2018 16:137

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    The Commentary to this article has been published in BMC Biology 2018 16:140

  42. Content type: Research article

    Mammalian cells are flexible and can rapidly change shape when they contract, adhere, or migrate. The nucleus must be stiff enough to withstand cytoskeletal forces, but flexible enough to remodel as the cell c...

    Authors: Elsie C. Jacobson, Jo K. Perry, David S. Long, Ada L. Olins, Donald E. Olins, Bryon E. Wright, Mark H. Vickers and Justin M. O’Sullivan

    Citation: BMC Biology 2018 16:142

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  43. Content type: Research article

    Bacteria and mitochondria contain translocases that function to transport proteins across or insert proteins into their inner and outer membranes. Extant mitochondria retain some bacterial-derived translocases...

    Authors: Markéta Petrů, Jeremy Wideman, Kristoffer Moore, Felicity Alcock, Tracy Palmer and Pavel Doležal

    Citation: BMC Biology 2018 16:141

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  44. Content type: Methodology article

    Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other su...

    Authors: Wei Qin, Xiaochan Lu, Yunxing Liu, Haipeng Bai, Song Li and Shuo Lin

    Citation: BMC Biology 2018 16:139

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  45. Content type: Research article

    Characterizing recurring sequence patterns in human promoters has been a challenging undertaking even nowadays where a near-complete overview of promoters exists. However, with the more recent availability of ...

    Authors: Xinyi Yang and Martin Vingron

    Citation: BMC Biology 2018 16:138

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