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  1. Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington’s disease (HD), the c...

    Authors: S. Fernández-García, J. G. Orlandi, G. A. García-Díaz Barriga, M. J. Rodríguez, M. Masana, J. Soriano and J. Alberch

    Citation: BMC Biology 2020 18:58

    Content type: Research article

    Published on:

  2. Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs). Recently, WGD w...

    Authors: Dick Roelofs, Arthur Zwaenepoel, Tom Sistermans, Joey Nap, Andries A. Kampfraath, Yves Van de Peer, Jacintha Ellers and Ken Kraaijeveld

    Citation: BMC Biology 2020 18:57

    Content type: Research article

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  3. Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis ...

    Authors: Timothy G. Stephens, Raúl A. González-Pech, Yuanyuan Cheng, Amin R. Mohamed, David W. Burt, Debashish Bhattacharya, Mark A. Ragan and Cheong Xin Chan

    Citation: BMC Biology 2020 18:56

    Content type: Research article

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  4. The cline of human genetic diversity observable across Europe is recapitulated at a micro-geographic scale by variation within the Italian population. Besides resulting from extensive gene flow, this might be ...

    Authors: Marco Sazzini, Paolo Abondio, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Matteo Ragno, Cristina Giuliani, Sara De Fanti, Claudia Ojeda-Granados, Alessio Boattini, Julien Marquis, Armand Valsesia, Jerome Carayol, Frederic Raymond, Chiara Pirazzini, Elena Marasco, Alberto Ferrarini…

    Citation: BMC Biology 2020 18:51

    Content type: Research article

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  5. For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been ...

    Authors: John J. Wright, Justin G. Fedor, Judy Hirst and Maxie M. Roessler

    Citation: BMC Biology 2020 18:54

    Content type: Research article

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  7. Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translationa...

    Authors: Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French and Benjamin Franklin Voight

    Citation: BMC Biology 2020 18:52

    Content type: Research article

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  8. The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and con...

    Authors: Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari and John M. Marshall

    Citation: BMC Biology 2020 18:50

    Content type: Research article

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  9. Mitochondria are essential organelles partially regulated by their own genomes. The mitochondrial genome maintenance and inheritance differ from the nuclear genome, potentially uncoupling their evolutionary tr...

    Authors: Matteo De Chiara, Anne Friedrich, Benjamin Barré, Michael Breitenbach, Joseph Schacherer and Gianni Liti

    Citation: BMC Biology 2020 18:49

    Content type: Research article

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  11. Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largel...

    Authors: Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco…

    Citation: BMC Biology 2020 18:47

    Content type: Research article

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  12. One hundred years ago, marine organisms were the dominant systems for the study of developmental biology. The challenges in rearing these organisms outside of a marine setting ultimately contributed to a shift...

    Authors: Jonathan Q. Henry, Maryna P. Lesoway and Kimberly J. Perry

    Citation: BMC Biology 2020 18:46

    Content type: Methodology article

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  13. The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experie...

    Authors: Elizabeth A. O’Brien, Kathleen S. Ensbey, Bryan W. Day, Paul A. Baldock and Guy Barry

    Citation: BMC Biology 2020 18:45

    Content type: Research article

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  14. Upon water uptake and release of seed dormancy, embryonic plant cells expand, while being mechanically constrained by the seed coat. Cortical microtubules (CMTs) are key players of cell elongation in plants: t...

    Authors: Huifang Yan, Nicole Chaumont, Jean François Gilles, Susanne Bolte, Olivier Hamant and Christophe Bailly

    Citation: BMC Biology 2020 18:44

    Content type: Research article

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  15. In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC ne...

    Authors: Alfonso Soler-Bistué, Sebastián Aguilar-Pierlé, Marc Garcia-Garcerá, Marie-Eve Val, Odile Sismeiro, Hugo Varet, Rodrigo Sieira, Evelyne Krin, Ole Skovgaard, Diego J. Comerci, Eduardo P. C. Rocha and Didier Mazel

    Citation: BMC Biology 2020 18:43

    Content type: Research article

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  16. Many long noncoding RNAs (lncRNAs) have been implicated in general and cell type-specific molecular regulation. Here, we asked what underlies the fundamental basis for the seemingly random appearance of nuclea...

    Authors: Markus Grosch, Sebastian Ittermann, Ejona Rusha, Tobias Greisle, Chaido Ori, Dong-Jiunn Jeffery Truong, Adam C. O’Neill, Anna Pertek, Gil Gregor Westmeyer and Micha Drukker

    Citation: BMC Biology 2020 18:42

    Content type: Research article

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  18. 5-Methylcytosine (m5C) is a prevalent base modification in tRNA and rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it serves incompletely understood molecular functions. In pu...

    Authors: Ulrike Schumann, He-Na Zhang, Tennille Sibbritt, Anyu Pan, Attila Horvath, Simon Gross, Susan J. Clark, Li Yang and Thomas Preiss

    Citation: BMC Biology 2020 18:40

    Content type: Research article

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  19. The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple c...

    Authors: Tess Cherlin, Rogan Magee, Yi Jing, Venetia Pliatsika, Phillipe Loher and Isidore Rigoutsos

    Citation: BMC Biology 2020 18:38

    Content type: Research article

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  20. The origin of animals from their unicellular ancestor was one of the most important events in evolutionary history, but the nature and the order of events leading up to the emergence of multicellular animals a...

    Authors: Denis V. Tikhonenkov, Elisabeth Hehenberger, Anton S. Esaulov, Olga I. Belyakova, Yuri A. Mazei, Alexander P. Mylnikov and Patrick J. Keeling

    Citation: BMC Biology 2020 18:39

    Content type: Research article

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  21. Metagenomics studies leverage genomic reference databases to generate discoveries in basic science and translational research. However, current microbial studies use disparate reference databases that lack con...

    Authors: Caitlin Loeffler, Aaron Karlsberg, Lana S. Martin, Eleazar Eskin, David Koslicki and Serghei Mangul

    Citation: BMC Biology 2020 18:37

    Content type: Comment

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  22. Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular t...

    Authors: Elena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova and Enni Markkanen

    Citation: BMC Biology 2020 18:36

    Content type: Research article

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  23. The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the em...

    Authors: Giulio Chiesa, Szilvia Kiriakov and Ahmad S. Khalil

    Citation: BMC Biology 2020 18:35

    Content type: Review

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  24. The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterat...

    Authors: Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Marta Marzullo, Laura Ciapponi, Aram Megighian, Monica Nizzardo and Fabian Feiguin

    Citation: BMC Biology 2020 18:34

    Content type: Research article

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  25. Current therapies for multiple myeloma (MM) are associated with toxicity and resistance, highlighting the need for novel effective therapeutics. Berberine (BBR), a botanical alkaloid derived from several Berbe...

    Authors: Chunming Gu, Zhao Yin, Hong Nie, Yanjun Liu, Juhua Yang, Guiping Huang, Jianping Shen, Liguo Chen and Jia Fei

    Citation: BMC Biology 2020 18:33

    Content type: Research article

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  26. Nuclear factor-κB (NF-κB) plays a prominent role in promoting inflammation and resistance to DNA damaging therapy. We searched for proteins that modulate the NF-κB response as a prerequisite to identifying nov...

    Authors: Szymon J. Szymura, Giovanna M. Bernal, Longtao Wu, Zhongqin Zhang, Clayton D. Crawley, David J. Voce, Paige-Ashley Campbell, Diana E. Ranoa, Ralph R. Weichselbaum and Bakhtiar Yamini

    Citation: BMC Biology 2020 18:32

    Content type: Research article

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  27. Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identi...

    Authors: Yu Toyoshima, Stephen Wu, Manami Kanamori, Hirofumi Sato, Moon Sun Jang, Suzu Oe, Yuko Murakami, Takayuki Teramoto, Chanhyun Park, Yuishi Iwasaki, Takeshi Ishihara, Ryo Yoshida and Yuichi Iino

    Citation: BMC Biology 2020 18:30

    Content type: Methodology article

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  28. Metabolic activity alternates between high and low states during different stages of an organism’s life cycle. During the transition from growth to quiescence, a major metabolic shift often occurs from oxidati...

    Authors: Sider Penkov, Bharath Kumar Raghuraman, Cihan Erkut, Jana Oertel, Roberta Galli, Eduardo Jacobo Miranda Ackerman, Daniela Vorkel, Jean-Marc Verbavatz, Edmund Koch, Karim Fahmy, Andrej Shevchenko and Teymuras V. Kurzchalia

    Citation: BMC Biology 2020 18:31

    Content type: Research article

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  30. Phosphoinositide lipids provide spatial landmarks during polarized cell growth and migration. Yet how phosphoinositide gradients are oriented in response to extracellular cues and environmental conditions is n...

    Authors: Deike J. Omnus, Angela Cadou, Ffion B. Thomas, Jakob M. Bader, Nathaniel Soh, Gary H. C. Chung, Andrew N. Vaughan and Christopher J. Stefan

    Citation: BMC Biology 2020 18:28

    Content type: Research article

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  31. CRISPR gene drive systems allow the rapid spread of a genetic construct throughout a population. Such systems promise novel strategies for the management of vector-borne diseases and invasive species by suppre...

    Authors: Jackson Champer, Isabel K. Kim, Samuel E. Champer, Andrew G. Clark and Philipp W. Messer

    Citation: BMC Biology 2020 18:27

    Content type: Research article

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  32. Aedes aegypti is the principal mosquito vector of Zika, dengue, and yellow fever viruses. Two subspecies of Ae. aegypti exhibit phenotypic divergence with regard to habitat, host preference, and vectorial capacit...

    Authors: Seth N. Redmond, Atashi Sharma, Igor Sharakhov, Zhijian Tu, Maria Sharakhova and Daniel E. Neafsey

    Citation: BMC Biology 2020 18:26

    Content type: Research article

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  34. Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that biva...

    Authors: Donnchadh S. Dunican, Heidi K. Mjoseng, Leanne Duthie, Ilya M. Flyamer, Wendy A. Bickmore and Richard R. Meehan

    Citation: BMC Biology 2020 18:25

    Content type: Research article

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  35. Contaminant DNA is a well-known confounding factor in molecular biology and in genomic repositories. Strikingly, analysis workflows for whole-genome sequencing (WGS) data commonly do not account for errors pot...

    Authors: Galo A. Goig, Silvia Blanco, Alberto L. Garcia-Basteiro and Iñaki Comas

    Citation: BMC Biology 2020 18:24

    Content type: Research article

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  36. The Euglenozoa are a protist group with an especially rich history of evolutionary diversity. They include diplonemids, representing arguably the most species-rich clade of marine planktonic eukaryotes; trypan...

    Authors: Anzhelika Butenko, Fred R. Opperdoes, Olga Flegontova, Aleš Horák, Vladimír Hampl, Patrick Keeling, Ryan M. R. Gawryluk, Denis Tikhonenkov, Pavel Flegontov and Julius Lukeš

    Citation: BMC Biology 2020 18:23

    Content type: Research article

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  37. Comparative analyses have indicated that the mitochondrion of the last eukaryotic common ancestor likely possessed all the key core structures and functions that are widely conserved throughout the domain Euca...

    Authors: Michael W. Gray, Gertraud Burger, Romain Derelle, Vladimír Klimeš, Michelle M. Leger, Matt Sarrasin, Čestmír Vlček, Andrew J. Roger, Marek Eliáš and B. Franz Lang

    Citation: BMC Biology 2020 18:22

    Content type: Research article

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  38. Recent developments within micro-computed tomography (μCT) imaging have combined to extend our capacity to image tissue in three (3D) and four (4D) dimensions at micron and sub-micron spatial resolutions, open...

    Authors: Shelley D. Rawson, Jekaterina Maksimcuka, Philip J. Withers and Sarah H. Cartmell

    Citation: BMC Biology 2020 18:21

    Content type: Review

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  39. The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair...

    Authors: Beáta Lizák, Julia Birk, Melinda Zana, Gergely Kosztyi, Denise V. Kratschmar, Alex Odermatt, Richard Zimmermann, Miklós Geiszt, Christian Appenzeller-Herzog and Gábor Bánhegyi

    Citation: BMC Biology 2020 18:19

    Content type: Research article

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  40. Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural gene...

    Authors: J. Alexander-Floyd, S. Haroon, M. Ying, A. A. Entezari, C. Jaeger, M. Vermulst and T. Gidalevitz

    Citation: BMC Biology 2020 18:18

    Content type: Research article

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  41. The Afrikaner population of South Africa is the descendants of European colonists who started to colonize the Cape of Good Hope in the 1600s. In the early days of the colony, mixed unions between European male...

    Authors: N. Hollfelder, J. C. Erasmus, R. Hammaren, M. Vicente, M. Jakobsson, J. M. Greeff and C. M. Schlebusch

    Citation: BMC Biology 2020 18:16

    Content type: Research article

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  42. In insects, continuous growth requires the periodic replacement of the exoskeleton. Once the remains of the exoskeleton from the previous stage have been shed during ecdysis, the new one is rapidly sclerotized...

    Authors: Justin Flaven-Pouchon, Javier V. Alvarez, Candy Rojas and John Ewer

    Citation: BMC Biology 2020 18:17

    Content type: Research article

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  43. In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient ...

    Authors: Anzer Khan, Simona Paro, Leeanne McGurk, Nagraj Sambrani, Marion C. Hogg, James Brindle, Giuseppa Pennetta, Liam P. Keegan and Mary A. O’Connell

    Citation: BMC Biology 2020 18:15

    Content type: Research article

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  44. The Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research.

    Authors: Katrina M. Morris, Matthew M. Hindle, Simon Boitard, David W. Burt, Angela F. Danner, Lel Eory, Heather L. Forrest, David Gourichon, Jerome Gros, LaDeana W. Hillier, Thierry Jaffredo, Hanane Khoury, Rusty Lansford, Christine Leterrier, Andrew Loudon, Andrew S. Mason…

    Citation: BMC Biology 2020 18:14

    Content type: Research article

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  45. Hybridisation and introgression play key roles in the evolutionary history of animal species. They are commonly observed within several orders in wild birds. The domestic chicken Gallus gallus domesticus is the m...

    Authors: Raman Akinyanju Lawal, Simon H. Martin, Koen Vanmechelen, Addie Vereijken, Pradeepa Silva, Raed Mahmoud Al-Atiyat, Riyadh Salah Aljumaah, Joram M. Mwacharo, Dong-Dong Wu, Ya-Ping Zhang, Paul M. Hocking, Jacqueline Smith, David Wragg and Olivier Hanotte

    Citation: BMC Biology 2020 18:13

    Content type: Research article

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  46. The gene content of a species largely governs its ecological interactions and adaptive potential. A species is therefore defined by both core genes shared between all individuals and accessory genes segregatin...

    Authors: Thomas Badet, Ursula Oggenfuss, Leen Abraham, Bruce A. McDonald and Daniel Croll

    Citation: BMC Biology 2020 18:12

    Content type: Research article

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  47. The invasive benthic round goby (Neogobius melanostomus) is the most successful temperate invasive fish and has spread in aquatic ecosystems on both sides of the Atlantic. Invasive species constitute powerful in ...

    Authors: Irene Adrian-Kalchhauser, Anders Blomberg, Tomas Larsson, Zuzana Musilova, Claire R. Peart, Martin Pippel, Monica Hongroe Solbakken, Jaanus Suurväli, Jean-Claude Walser, Joanna Yvonne Wilson, Magnus Alm Rosenblad, Demian Burguera, Silvia Gutnik, Nico Michiels, Mats Töpel, Kirill Pankov…

    Citation: BMC Biology 2020 18:11

    Content type: Research article

    Published on:

  48. The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it...

    Authors: Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers and Didier Picard

    Citation: BMC Biology 2020 18:10

    Content type: Research article

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  49. It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid ...

    Authors: Attila Köfalvi, Estefanía Moreno, Arnau Cordomí, Ning-Sheng Cai, Victor Fernández-Dueñas, Samira G. Ferreira, Ramón Guixà-González, Marta Sánchez-Soto, Hideaki Yano, Verònica Casadó-Anguera, Rodrigo A. Cunha, Ana Maria Sebastião, Francisco Ciruela, Leonardo Pardo, Vicent Casadó and Sergi Ferré

    Citation: BMC Biology 2020 18:9

    Content type: Research article

    Published on:

  50. Two-pore channels (TPCs) release Ca2+ from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoeba Dictyostelium discoideum proliferates...

    Authors: Fu-Sheng Chang, Yuntao Wang, Phillip Dmitriev, Julian Gross, Antony Galione and Catherine Pears

    Citation: BMC Biology 2020 18:8

    Content type: Research article

    Published on:

Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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