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  1. Understanding the evolutionary genetics of modern crop phenotypes has a dual relevance to evolutionary biology and crop improvement. Modern upland cotton (Gossypium hirsutum L.) was developed following thousands ...

    Authors: Ryan A Rapp, Candace H Haigler, Lex Flagel, Ran H Hovav, Joshua A Udall and Jonathan F Wendel
    Citation: BMC Biology 2010 8:139
  2. Polymodal, nociceptive sensory neurons are key cellular elements of the way animals sense aversive and painful stimuli. In Caenorhabditis elegans, the polymodal nociceptive ASH sensory neurons detect aversive sti...

    Authors: Giovanni Esposito, Maria R Amoroso, Carmela Bergamasco, Elia Di Schiavi and Paolo Bazzicalupo
    Citation: BMC Biology 2010 8:138
  3. A new study of divergence in freshwater fish provides strong evidence of rapid, temperature-mediated adaptation. This study is particularly important in the ongoing debate over the extent and significance of e...

    Authors: David Skelly
    Citation: BMC Biology 2010 8:136
  4. White-nose syndrome (WNS) is causing unprecedented declines in several species of North American bats. The characteristic lesions of WNS are caused by the fungus Geomyces destructans, which erodes and replaces th...

    Authors: Paul M Cryan, Carol Uphoff Meteyer, Justin G Boyles and David S Blehert
    Citation: BMC Biology 2010 8:135
  5. Color vision plays a critical role in visual behavior. An animal's capacity for color vision rests on the presence of differentially sensitive cone photoreceptors. Spectral sensitivity is a measure of the visu...

    Authors: Shai Sabbah, Raico Lamela Laria, Suzanne M Gray and Craig W Hawryshyn
    Citation: BMC Biology 2010 8:133
  6. Unrepaired DNA double-stranded breaks (DSBs) cause chromosomal rearrangements, loss of genetic information, neoplastic transformation or cell death. The nonhomologous end joining (NHEJ) pathway, catalyzing seq...

    Authors: Sarah A Maas, Nina M Donghia, Kathleen Tompkins, Oded Foreman and Kevin D Mills
    Citation: BMC Biology 2010 8:132
  7. Several recent papers, including one in BMC Evolutionary Biology, examine the colonization history of house mice. As well as background for the analysis of mouse adaptation, such studies offer a perspective on th...

    Authors: Sofia I Gabriel, Fríða Jóhannesdóttir, Eleanor P Jones and Jeremy B Searle
    Citation: BMC Biology 2010 8:131
  8. The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the...

    Authors: Linda M Nevin, Estuardo Robles, Herwig Baier and Ethan K Scott
    Citation: BMC Biology 2010 8:126
  9. A growing body of evidence has shown that Krüppel-like transcription factors play a crucial role in maintaining embryonic stem cell (ESC) pluripotency and in governing ESC fate decisions. Krüppel-like factor 5...

    Authors: Silvia Parisi, Luca Cozzuto, Carolina Tarantino, Fabiana Passaro, Simona Ciriello, Luigi Aloia, Dario Antonini, Vincenzo De Simone, Lucio Pastore and Tommaso Russo
    Citation: BMC Biology 2010 8:128
  10. The recent identification of the gammaretrovirus XMRV and a second gammaretrovirus of a different subtype in chronic fatigue syndrome has aroused much interest, not least among sufferers. However, it remains h...

    Authors: Robin A Weiss
    Citation: BMC Biology 2010 8:124
  11. An increasing number of publications demonstrate conservation of function of cis-regulatory elements without sequence similarity. In invertebrates such functional conservation has only been shown for closely r...

    Authors: Savita Ayyar, Barbara Negre, Pat Simpson and Angelika Stollewerk
    Citation: BMC Biology 2010 8:127
  12. Abdominal wounding by traumatic insemination and the lack of a long distance attraction pheromone set the scene for unusual sexual signalling systems. Male bed bugs (Cimex lectularius) mount any large, newly fed ...

    Authors: Vincent Harraca, Camilla Ryne and Rickard Ignell
    Citation: BMC Biology 2010 8:121
  13. A recent study in BMC Biology has determined that the immature stage of the bed bug (the nymph) signals its reproductive status to adult males using pheromones and thus avoids the trauma associated with copulatio...

    Authors: Kenneth F Haynes, Mark H Goodman and Michael F Potter
    Citation: BMC Biology 2010 8:117
  14. This paper is a response to Gray MM, Sutter NB, Ostrander EA, Wayne RK: The IGF1 small dog haplotype is derived from Middle Eastern grey wolves. BMC Biology 2010, 8:16.

    Authors: Cornelya FC Klütsch and M Dominique Crapon de Caprona
    Citation: BMC Biology 2010 8:119
  15. Insects, like most organisms, have an internal circadian clock that oscillates with a daily rhythmicity, and a timing mechanism that mediates seasonal events, including diapause. In research published in BMC B...

    Authors: William E Bradshaw and Christina M Holzapfel
    Citation: BMC Biology 2010 8:115
  16. Relaxed molecular clock models allow divergence time dating and "relaxed phylogenetic" inference, in which a time tree is estimated in the face of unequal rates across lineages. We present a new method for rel...

    Authors: Alexei J Drummond and Marc A Suchard
    Citation: BMC Biology 2010 8:114
  17. Hormones are critical for early gonadal development in nonmammalian vertebrates, and oestrogen is required for normal ovarian development. In contrast, mammals determine sex by the presence or absence of the SRY ...

    Authors: Andrew J Pask, Natalie E Calatayud, Geoff Shaw, William M Wood and Marilyn B Renfree
    Citation: BMC Biology 2010 8:113
  18. Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by ...

    Authors: Lindsey Mork and Blanche Capel
    Citation: BMC Biology 2010 8:110
  19. Human cases of plague (Yersinia pestis) infection originate, ultimately, in the bacterium's wildlife host populations. The epidemiological dynamics of the wildlife reservoir therefore determine the abundance, dis...

    Authors: Kyrre Linné Kausrud, Mike Begon, Tamara Ben Ari, Hildegunn Viljugrein, Jan Esper, Ulf Büntgen, Herwig Leirs, Claudia Junge, Bao Yang, Meixue Yang, Lei Xu and Nils Chr Stenseth
    Citation: BMC Biology 2010 8:112
  20. Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis sugg...

    Authors: Jörg Barke, Ryan F Seipke, Sabine Grüschow, Darren Heavens, Nizar Drou, Mervyn J Bibb, Rebecca JM Goss, Douglas W Yu and Matthew I Hutchings
    Citation: BMC Biology 2010 8:109
  21. Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carb...

    Authors: Robert A Cross
    Citation: BMC Biology 2010 8:107
  22. CTCF is a versatile zinc finger DNA-binding protein that functions as a highly conserved epigenetic transcriptional regulator. CTCF is known to act as a chromosomal insulator, bind promoter regions, and facili...

    Authors: William A MacDonald, Debashish Menon, Nicholas J Bartlett, G Elizabeth Sperry, Vanya Rasheva, Victoria Meller and Vett K Lloyd
    Citation: BMC Biology 2010 8:105
  23. The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible...

    Authors: Chunhui Hou and Victor G Corces
    Citation: BMC Biology 2010 8:104
  24. The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafi...

    Authors: Christopher W Wilson and Didier YR Stainier
    Citation: BMC Biology 2010 8:102
  25. Whilst parthenogenesis has evolved multiple times from sexual invertebrate and vertebrate lineages, the drivers and consequences of the sex-asex transition remain mostly uncertain. A model by Stouthamer et al. re...

    Authors: Kayla C King and Gregory DD Hurst
    Citation: BMC Biology 2010 8:101
  26. The evolution of multicellular motile organisms from unicellular ancestors required the utilization of previously evolved tactic behavior in a multicellular context. Volvocine green algae are uniquely suited f...

    Authors: Noriko Ueki, Shigeru Matsunaga, Isao Inouye and Armin Hallmann
    Citation: BMC Biology 2010 8:103
  27. Mitochondria are highly dynamic organelles whose morphology and position within the cell is tightly coupled to metabolic function. There is a limited list of essential proteins that regulate mitochondrial morp...

    Authors: Astrid C Schauss, Huiyan Huang, Seok-Yong Choi, Liqun Xu, Sébastien Soubeyrand, Patricia Bilodeau, Rodolfo Zunino, Peter Rippstein, Michael A Frohman and Heidi M McBride
    Citation: BMC Biology 2010 8:100
  28. Several recent papers illustrate the importance of migration and gene flow in molding the patterns of genetic variation observed in humans today. We place the varied demographic processes covered by these term...

    Authors: Murray P Cox and Michael F Hammer
    Citation: BMC Biology 2010 8:98
  29. Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor ...

    Authors: Philipp Alberts and Daniela Rotin
    Citation: BMC Biology 2010 8:94
  30. Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria p...

    Authors: Bridget Penman, Caroline Buckee, Sunetra Gupta and Sean Nee
    Citation: BMC Biology 2010 8:90
  31. Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This...

    Authors: Damien Chaussabel, Virginia Pascual and Jacques Banchereau
    Citation: BMC Biology 2010 8:84