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  1. Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggre...

    Authors: Yongfeng Luo, Elie El Agha, Gianluca Turcatel, Hui Chen, Joanne Chiu, David Warburton, Saverio Bellusci, Bang-Ping Qian, Douglas B. Menke and Wei Shi
    Citation: BMC Biology 2015 13:42
    Content type: Research article Published on:

  2. We report here the first genome-wide high-resolution polymorphism resource for non-human primate (NHP) association and linkage studies, constructed for the Caribbean-origin vervet monkey, or African green monk...

    Authors: Yu S. Huang, Vasily Ramensky, Susan K. Service, Anna J. Jasinska, Yoon Jung, Oi-Wa Choi, Rita M. Cantor, Nikoleta Juretic, Jessica Wasserscheid, Jay R. Kaplan, Matthew J. Jorgensen, Thomas D. Dyer, Ken Dewar, John Blangero, Richard K. Wilson, Wesley Warren…
    Citation: BMC Biology 2015 13:41
    Content type: Research article Published on:

  4. The early stages of ovarian follicle formation—beginning with the breakdown of germ cell cysts and continuing with the formation of primordial follicles and transition to primary and secondary follicles—are cr...

    Authors: Yu Ren, Hitomi Suzuki, Krishna Jagarlamudi, Kayla Golnoski, Megan McGuire, Rita Lopes, Vassilis Pachnis and Aleksandar Rajkovic
    Citation: BMC Biology 2015 13:39
    Content type: Research article Published on:

  6. Chromosomes reorganize in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localize to the nuclear periphery via interaction of the telomeric protein Rap1 with the mem...

    Authors: Hanna Amelina, Shaan Subramaniam, Vera Moiseeva, Christine Anne Armstrong, Siân Rosanna Pearson and Kazunori Tomita
    Citation: BMC Biology 2015 13:37
    Content type: Research article Published on:

  11. Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing reg...

    Authors: Eneritz Agirre, Nicolás Bellora, Mariano Alló, Amadís Pagès, Paola Bertucci, Alberto R Kornblihtt and Eduardo Eyras
    Citation: BMC Biology 2015 13:31
    Content type: Research article Published on:

  12. Photoreceptor degeneration is a main hallmark of many blinding diseases making protection of photoreceptors crucial to prevent vision loss. Thus, regulation of endogenous neuroprotective factors may be key for...

    Authors: Cavit Agca, Karsten Boldt, Andrea Gubler, Isabelle Meneau, Armelle Corpet, Marijana Samardzija, Manuel Stucki, Marius Ueffing and Christian Grimm
    Citation: BMC Biology 2015 13:30
    Content type: Research article Published on:

  13. The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut...

    Authors: José M Martín-Durán and Andreas Hejnol
    Citation: BMC Biology 2015 13:29
    Content type: Research article Published on:

  14. Jasmonates are well known plant signaling components required for stress responses and development. A prominent feature of jasmonate biosynthesis or signaling mutants is the loss of fertility. In contrast to t...

    Authors: Susanne Dobritzsch, Martin Weyhe, Ramona Schubert, Julian Dindas, Gerd Hause, Joachim Kopka and Bettina Hause
    Citation: BMC Biology 2015 13:28
    Content type: Research article Published on:

  15. Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca2+-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of compl...

    Authors: Umakhanth Venkatraman Girija, Christopher M Furze, Alexandre R Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie E Marshall, A Katrine Wallis, Wilhelm J Schwaeble, Mohammed El-Mezgueldi, Daniel A Mitchell, Peter CE Moody, Nobutaka Wakamiya and Russell Wallis
    Citation: BMC Biology 2015 13:27
    Content type: Research article Published on:

  16. Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a ge...

    Authors: Luis A Aguirre, M Eva Alonso, Claudio Badía-Careaga, Isabel Rollán, Cristina Arias, Ana Fernández-Miñán, Elena López-Jiménez, Amelia Aránega, José Luis Gómez-Skarmeta, Diego Franco and Miguel Manzanares
    Citation: BMC Biology 2015 13:26
    Content type: Research article Published on:

  17. Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one of the main driving factors of human malignancies. They function as transcription factors that (i...

    Authors: Eva K Herter, Maria Stauch, Maria Gallant, Elmar Wolf, Thomas Raabe and Peter Gallant
    Citation: BMC Biology 2015 13:25
    Content type: Research article Published on:

  18. Fixation of beneficial genes in bacteria and archaea (collectively, prokaryotes) is often believed to erase pre-existing genomic diversity through the hitchhiking effect, a phenomenon known as genome-wide sele...

    Authors: Nobuto Takeuchi, Otto X Cordero, Eugene V Koonin and Kunihiko Kaneko
    Citation: BMC Biology 2015 13:20
    Content type: Research article Published on:

  19. β-catenin plays a central role in multiple developmental processes. However, it has been difficult to study its pleiotropic effects, because of the dual capacity of β-catenin to coordinate cadherin-dependent c...

    Authors: Max Hans-Peter Gay, Tomas Valenta, Patrick Herr, Lisette Paratore-Hari, Konrad Basler and Lukas Sommer
    Citation: BMC Biology 2015 13:24
    Content type: Research article Published on:

  20. The pilidium larva is a novel body plan that arose within a single clade in the phylum Nemertea - the Pilidiophora. While the sister clade of the Pilidiophora and the basal nemerteans develop directly, pilidio...

    Authors: Laurel S Hiebert and Svetlana A Maslakova
    Citation: BMC Biology 2015 13:23
    Content type: Research article Published on:

  22. We recently identified a novel protein, Rearranged L-myc fusion (Rlf), that is required for DNA hypomethylation and transcriptional activity at two specific regions of the genome known to be sensitive to epige...

    Authors: Sarah K Harten, Harald Oey, Lauren M Bourke, Vandhana Bharti, Luke Isbel, Lucia Daxinger, Pierre Faou, Neil Robertson, Jacqueline M Matthews and Emma Whitelaw
    Citation: BMC Biology 2015 13:21
    Content type: Research article Published on:

  23. The degree of genetic differentiation among populations experiencing high levels of gene flow is expected to be low for neutral genomic sites, but substantial divergence can occur in sites subject to direction...

    Authors: Baocheng Guo, Jacquelin DeFaveri, Graciela Sotelo, Abhilash Nair and Juha Merilä
    Citation: BMC Biology 2015 13:19
    Content type: Research article Published on:

  25. Circadian clocks control rhythmic expression of a large number of genes in coordination with the 24 hour day-night cycle. The mechanisms generating circadian rhythms, their amplitude and circadian phase are de...

    Authors: Cigdem Sancar, Gencer Sancar, Nati Ha, François Cesbron and Michael Brunner
    Citation: BMC Biology 2015 13:17
    Content type: Research article Published on:

  26. High-throughput sequencing technologies are lifting major limitations to molecular-based ecological studies of eukaryotic microbial diversity, but analyses of the resulting millions of short sequences remain a...

    Authors: Dominik Forster, Lucie Bittner, Slim Karkar, Micah Dunthorn, Sarah Romac, Stéphane Audic, Philippe Lopez, Thorsten Stoeck and Eric Bapteste
    Citation: BMC Biology 2015 13:16
    Content type: Research article Published on:

  27. Sleep is characterized by extended periods of quiescence and reduced responsiveness to sensory stimuli. Animals ranging from insects to mammals adapt to environments with limited food by suppressing sleep and ...

    Authors: Masato Yoshizawa, Beatriz G Robinson, Erik R Duboué, Pavel Masek, James B Jaggard, Kelly E O’Quin, Richard L Borowsky, William R Jeffery and Alex C Keene
    Citation: BMC Biology 2015 13:15
    Content type: Research article Published on:

  29. How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understandi...

    Authors: Gentian Buzi, Arthur D Lander and Mustafa Khammash
    Citation: BMC Biology 2015 13:13
    Content type: Research article Published on:

  30. Macrophages have many functions in development and homeostasis as well as innate immunity. Recent studies in mammals suggest that cells arising in the yolk sac give rise to self-renewing macrophage populations...

    Authors: Valerie Garceau, Adam Balic, Carla Garcia-Morales, Kristin A Sauter, Mike J McGrew, Jacqueline Smith, Lonneke Vervelde, Adrian Sherman, Troy E Fuller, Theodore Oliphant, John A Shelley, Raksha Tiwari, Thomas L Wilson, Cosmin Chintoan-Uta, Dave W Burt, Mark P Stevens…
    Citation: BMC Biology 2015 13:12
    Content type: Research article Published on:

  31. Variations in floral display represent one of the core features associated with the transition from allogamy to autogamy in angiosperms. The promotion of autogamy under stress conditions suggests the potential...

    Authors: Sherif Sherif, Islam El-Sharkawy, Jaideep Mathur, Pratibha Ravindran, Prakash Kumar, Gopinadhan Paliyath and Subramanian Jayasankar
    Citation: BMC Biology 2015 13:11
    Content type: Research article Published on:

  32. Normal brain function depends on the development of appropriate patterns of neural connections. A critical role in guiding axons to their targets during neural development is played by neuronal growth cones. T...

    Authors: Geoffrey J Goodhill, Richard A Faville, Daniel J Sutherland, Brendan A Bicknell, Andrew W Thompson, Zac Pujic, Biao Sun, Elizabeth M Kita and Ethan K Scott
    Citation: BMC Biology 2015 13:10
    Content type: Research Article Published on:

  35. In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could ...

    Authors: Marc Jung and Gerd P Pfeifer
    Citation: BMC Biology 2015 13:7
    Content type: Opinion Published on:

  36. The nematode worm Caenorhabditis elegans, in which loss-of-function mutants and RNA interference (RNAi) models are available, is a model organism useful for analyzing effects of genes on various life phenomena, i...

    Authors: Masayuki Hamakawa, Takayuki Uozumi, Naoko Ueda, Yuichi Iino and Takaaki Hirotsu
    Citation: BMC Biology 2015 13:6
    Content type: Research article Published on:

  38. Tissue-specific RNA plasticity broadly impacts the development, tissue identity and adaptability of all organisms, but changes in composition, expression levels and its impact on gene regulation in different s...

    Authors: Stephen M Blazie, Cody Babb, Henry Wilky, Alan Rawls, Jin G Park and Marco Mangone
    Citation: BMC Biology 2015 13:4
    Content type: Research article Published on:

  39. The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the...

    Authors: Anna Beckmann, Senbo Xiao, Jochen P Müller, Davide Mercadante, Timm Nüchter, Niels Kröger, Florian Langhojer, Wolfgang Petrich, Thomas W Holstein, Martin Benoit, Frauke Gräter and Suat Özbek
    Citation: BMC Biology 2015 13:3
    Content type: Research article Published on:

  40. Endoplasmic reticulum (ER) lumenal protein thiol redox balance resists dramatic variation in unfolded protein load imposed by diverse physiological challenges including compromise in the key upstream oxidases....

    Authors: Edward Avezov, Tasuku Konno, Alisa Zyryanova, Weiyue Chen, Romain Laine, Ana Crespillo-Casado, Eduardo Pinho Melo, Ryo Ushioda, Kazuhiro Nagata, Clemens F Kaminski, Heather P Harding and David Ron
    Citation: BMC Biology 2015 13:2
    Content type: Research article Published on:

  41. Adenosine-to-inosine RNA editing is a highly conserved process that post-transcriptionally modifies mRNA, generating proteomic diversity, particularly within the nervous system of metazoans. Transcripts encodi...

    Authors: Leila E Rieder, Yiannis A Savva, Matthew A Reyna, Yao-Jen Chang, Jacquelyn S Dorsky, Ali Rezaei and Robert A Reenan
    Citation: BMC Biology 2015 13:1
    Content type: Research article Published on:

  42. The public health threats imposed by toxoplasmosis worldwide and by malaria in sub-Saharan countries are directly associated with the capacity of their related causative agents Toxoplasma and Plasmodium, respe...

    Authors: Marion Bichet, Candie Joly, Ahmed Hadj Henni, Thomas Guilbert, Marie Xémard, Vincent Tafani, Vanessa Lagal, Guillaume Charras and Isabelle Tardieux
    Citation: BMC Biology 2014 12:773
    Content type: Research article Published on:

  43. Despite being a fundamental biological problem the control of body size and proportions during development remains poorly understood, although it is accepted that the insulin-like growth factor (IGF) pathway h...

    Authors: Marta Madon-Simon, Michael Cowley, Alastair S Garfield, Kim Moorwood, Steven R Bauer and Andrew Ward
    Citation: BMC Biology 2014 12:771
    Content type: Research article Published on:

  45. Nucleosome organization determines the chromatin state, which in turn controls gene expression or silencing. Nucleosome remodeling occurs during somatic cell reprogramming, but it is still unclear to what degr...

    Authors: Yu Tao, Weisheng Zheng, Yonghua Jiang, Guitao Ding, Xinfeng Hou, Yitao Tang, Yueying Li, Shuai Gao, Gang Chang, Xiaobai Zhang, Wenqiang Liu, Xiaochen Kou, Hong Wang, Cizhong Jiang and Shaorong Gao
    Citation: BMC Biology 2014 12:109
    Content type: Research article Published on:

  46. As individual naïve CD4 T lymphocytes circulate in the body after emerging from the thymus, they are likely to have individually varying microenvironmental interactions even in the absence of stimulation via s...

    Authors: Sanket Rane, Rituparna Das, Vidya Ranganathan, Savit Prabhu, Arundhoti Das, Hamid Mattoo, Jeannine Marie Durdik, Anna George, Satyajit Rath and Vineeta Bal
    Citation: BMC Biology 2014 12:106
    Content type: Research article Published on:

  48. Almost all cells display circadian rhythms, approximately 24-hour period changes in their biochemistry, physiology or behavior. These rhythms are orchestrated by an endogenous circadian clock whose mechanism i...

    Authors: Sougata Roy, Mathieu Beauchemin, Steve Dagenais-Bellefeuille, Louis Letourneau, Mario Cappadocia and David Morse
    Citation: BMC Biology 2014 12:107
    Content type: Research article Published on:

  49. Archaea share fundamental properties with bacteria and eukaryotes. Yet, they also possess unique attributes, which largely remain poorly characterized. Haloferax volcanii is an aerobic, moderately halophilic arch...

    Authors: Saija Kiljunen, Maria I Pajunen, Kieran Dilks, Stefanie Storf, Mechthild Pohlschroder and Harri Savilahti
    Citation: BMC Biology 2014 12:103
    Content type: Research article Published on:
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