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  1. Genome-wide assays performed in Arabidopsis and other organisms have revealed that the translation status of mRNAs responds dramatically to different environmental stresses and genetic lesions in the translation ...

    Authors: Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R Gallie, Bijoyita Roy and Albrecht G von Arnim
    Citation: BMC Biology 2013 11:123
    Content type: Research article Published on:

  2. The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enz...

    Authors: Meike Baumgart, Kerstin Luder, Shipra Grover, Cornelia Gätgens, Gurdyal S Besra and Julia Frunzke
    Citation: BMC Biology 2013 11:122
    Content type: Research article Published on:

  3. ICE (Inducer of CBF Expression) family genes play an important role in the regulation of cold tolerance pathways. In an earlier study, we isolated the gene CdICE1 from Chrysanthemum dichrum and demonstrated that ...

    Authors: Yu Chen, Jiafu Jiang, Aiping Song, Sumei Chen, Hong Shan, Huolin Luo, Chunsun Gu, Jing Sun, Lu Zhu, Weimin Fang and Fadi Chen
    Citation: BMC Biology 2013 11:121
    Content type: Research article Published on:

  4. The lag phase of bacterial growth is important from a medical and food safety perspective, but difficult to study due to the low density and metabolic rate of cells. A new study by Alon and colleagues reveals ...

    Authors: Daniel Schultz and Roy Kishony
    Citation: BMC Biology 2013 11:120
    Content type: Commentary Published on:

  10. Embryonic lung development is instructed by crosstalk between mesenchyme and epithelia, which results in activation of transcriptional factors, such as Sox9, in a temporospatial manner. Sox9 is expressed in both ...

    Authors: Gianluca Turcatel, Nicole Rubin, Douglas B Menke, Gary Martin, Wei Shi and David Warburton
    Citation: BMC Biology 2013 11:117
    Content type: Research article Published on:

  11. The tumor suppressor protein p53 is activated by cellular stress. DNA double strand breaks (DSBs) induce the activation of the kinase ATM, which stabilizes p53 and activates its transcriptional activity. Singl...

    Authors: Alexander Loewer, Ketki Karanam, Caroline Mock and Galit Lahav
    Citation: BMC Biology 2013 11:114
    Content type: Research article Published on:

  13. Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epith...

    Authors: Wenming Zhang, Douglas B Menke, Meisheng Jiang, Hui Chen, David Warburton, Gianluca Turcatel, Chi-Han Lu, Wei Xu, Yongfeng Luo and Wei Shi
    Citation: BMC Biology 2013 11:111
    Content type: Methodology article Published on:

  17. Neural crest defects lead to congenital heart disease involving outflow tract malformation. Integrin-linked-kinase (ILK) plays important roles in multiple cellular processes and embryogenesis. ILK is expressed...

    Authors: Xiuqin Dai, Weijian Jiang, Qingquan Zhang, Lian Xu, Peng Geng, Shaowei Zhuang, Brian G Petrich, Cizhong Jiang, Luying Peng, Shoumo Bhattacharya, Sylvia M Evans, Yunfu Sun, Ju Chen and Xingqun Liang
    Citation: BMC Biology 2013 11:107
    Content type: Research article Published on:

  18. The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are...

    Authors: Jean-François Schmouth, Mauro Castellarin, Stéphanie Laprise, Kathleen G Banks, Russell J Bonaguro, Simone C McInerny, Lisa Borretta, Mahsa Amirabbasi, Andrea J Korecki, Elodie Portales-Casamar, Gary Wilson, Lisa Dreolini, Steven JM Jones, Wyeth W Wasserman, Daniel Goldowitz, Robert A Holt…
    Citation: BMC Biology 2013 11:106
    Content type: Research article Published on:

  19. Color traits in animals play crucial roles in thermoregulation, photoprotection, camouflage, and visual communication, and are amenable to objective quantification and modeling. However, the extensive variatio...

    Authors: Suzanne V Saenko, Jérémie Teyssier, Dirk van der Marel and Michel C Milinkovitch
    Citation: BMC Biology 2013 11:105
    Content type: Research article Published on:

  20. Wnt6 is an evolutionarily ancient member of the Wnt family. In Drosophila, Wnt6 loss-of-function animals have not yet been reported, hence information about fly Wnt6 function is lacking. In wing discs, Wnt6 is ex...

    Authors: Nikolaos Doumpas, Gáspár Jékely and Aurelio A Teleman
    Citation: BMC Biology 2013 11:104
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Biology 2015 13:100

  23. Monogenic gain-of-function protein aggregation diseases, including Huntington’s disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with simila...

    Authors: Tali Gidalevitz, Ning Wang, Tanuja Deravaj, Jasmine Alexander-Floyd and Richard I Morimoto
    Citation: BMC Biology 2013 11:100
    Content type: Research article Published on:

  25. Innate immune responses are evolutionarily conserved processes that provide crucial protection against invading organisms. Gene activation by potent NF-κB transcription factors is essential both in mammals and Dr...

    Authors: Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow and Ylva Engström
    Citation: BMC Biology 2013 11:99
    Content type: Research article Published on:

  26. Some of the most marked temporal fluctuations in species abundances are linked to seasons. In theory, multispecies assemblages can persist if species use shared resources at different times, thereby minimizing...

    Authors: Hideyasu Shimadzu, Maria Dornelas, Peter A Henderson and Anne E Magurran
    Citation: BMC Biology 2013 11:98
    Content type: Research article Published on:

  27. The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments ...

    Authors: Alan S Perelson and Ruy M Ribeiro
    Citation: BMC Biology 2013 11:96
    Content type: Review Published on:

  32. Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype r...

    Authors: Rita JM Volkers, L Basten Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman and Jan E Kammenga
    Citation: BMC Biology 2013 11:93
    Content type: Research article Published on:

  33. Subterranean blind mole rats (Spalax) are hypoxia tolerant (down to 3% O2), long lived (>20 years) rodents showing no clear signs of aging or aging related disorders. In 50 years of Spalax research, spontaneous t...

    Authors: Irena Manov, Mark Hirsh, Theodore C Iancu, Assaf Malik, Nick Sotnichenko, Mark Band, Aaron Avivi and Imad Shams
    Citation: BMC Biology 2013 11:91
    Content type: Research article Published on:

  34. Most eukaryotic species represent stable karyotypes with a particular diploid number. B chromosomes are additional to standard karyotypes and may vary in size, number and morphology even between cells of the s...

    Authors: Vladimir A Trifonov, Polina V Dementyeva, Denis M Larkin, Patricia CM O’Brien, Polina L Perelman, Fengtang Yang, Malcolm A Ferguson-Smith and Alexander S Graphodatsky
    Citation: BMC Biology 2013 11:90
    Content type: Research article Published on:

  35. In HIV-1-infected human monocyte-derived macrophages (MDMs), virus particles assemble primarily on intracellularly sequestered plasma membrane domains termed intracellular plasma membrane-connected compartment...

    Authors: Petra Mlcochova, Annegret Pelchen-Matthews and Mark Marsh
    Citation: BMC Biology 2013 11:89
    Content type: Research article Published on:

  36. Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mecha...

    Authors: Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Teresa Muñoz-Yagüe and José A Solís-Herruzo
    Citation: BMC Biology 2013 11:88
    Content type: Research article Published on:

  38. Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods tha...

    Authors: Guanghua Yang, Karim Si-Tayeb, Sébastien Corbineau, Rémi Vernet, Régis Gayon, Noushin Dianat, Clémence Martinet, Denis Clay, Sylvie Goulinet-Mainot, Gérard Tachdjian, Gérard Tachdjian, Deborah Burks, Ludovic Vallier, Pascale Bouillé, Anne Dubart-Kupperschmitt and Anne Weber
    Citation: BMC Biology 2013 11:86
    Content type: Research article Published on:

  40. Molecular phylogenetic analyses are used increasingly in the epidemiological investigation of outbreaks and transmission cases involving rapidly evolving RNA viruses. Here, we present the results of such an an...

    Authors: Fernando González-Candelas, María Alma Bracho, Borys Wróbel and Andrés Moya
    Citation: BMC Biology 2013 11:76
    Content type: Research article Published on:

  41. Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the hormone’s source. In contrast, little is known ab...

    Authors: Rochele Yamamoto, Hua Bai, Adam G Dolezal, Gro Amdam and Marc Tatar
    Citation: BMC Biology 2013 11:85
    Content type: Research article Published on:

  42. The role of histone variants and their specific post-translational modifications (PTMs) in the epigenetic regulation of gene expression is still poorly understood. A paper published by Simonet and colleagues in E...

    Authors: Juan Ausió
    Citation: BMC Biology 2013 11:84
    Content type: Commentary Published on:

  44. Vibration attraction behavior (VAB) is the swimming of fish toward an oscillating object, a behavior that is likely adaptive because it increases foraging efficiency in darkness. VAB is seen in a small proport...

    Authors: Masato Yoshizawa, Kelly E O’Quin and William R Jeffery
    Citation: BMC Biology 2013 11:82
    Content type: Correspondence Published on:

  46. It is clear that the coordinated and reciprocal actions of kinases and phosphatases are fundamental in the regulation of development and growth of the malaria parasite. Protein Phosphatase type 1 is a key enzy...

    Authors: Aline Fréville, Katia Cailliau-Maggio, Christine Pierrot, Géraldine Tellier, Hadidjatou Kalamou, Sophia Lafitte, Alain Martoriati, Raymond J Pierce, Jean-François Bodart and Jamal Khalife
    Citation: BMC Biology 2013 11:80
    Content type: Research article Published on:

  47. NEUROG3 is a key regulator of pancreatic endocrine cell differentiation in mouse, essential for the generation of all mature hormone producing cells. It is repressed by Notch signaling that prevents pancreatic...

    Authors: Lydie C Flasse, Justine L Pirson, David G Stern, Virginie Von Berg, Isabelle Manfroid, Bernard Peers and Marianne L Voz
    Citation: BMC Biology 2013 11:78
    Content type: Research article Published on:

  48. Two competing theories have been advanced to explain the evolution of multiple cone classes in vertebrate eyes. These two theories have important, but different, implications for our understanding of the desig...

    Authors: Shai Sabbah and Craig W Hawryshyn
    Citation: BMC Biology 2013 11:77
    Content type: Research article Published on:

  49. In most modern bony fishes (teleosts) hearing improvement is often correlated with a close morphological relationship between the swim bladder or other gas-filled cavities and the saccule or more rarely with t...

    Authors: Tanja Schulz-Mirbach, Martin Heß, Brian D Metscher and Friedrich Ladich
    Citation: BMC Biology 2013 11:75
    Content type: Research article Published on:

  50. Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How mammalian cilia function in vivo as mechanosensors, signal ...

    Authors: Iain A Drummond
    Citation: BMC Biology 2013 11:74
    Content type: Commentary Published on:
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