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  1. Content type: Research Article

    For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-ori...

    Authors: Yasushi Saka, Claudiu V. Giuraniuc and Hiroyuki Ohkura

    Citation: BMC Biology 2015 13:65

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  2. Content type: Interview

    Tim Hunt took an undergraduate degree in Natural Sciences at Cambridge in 1964, and his PhD and subsequent work focussed on the control of protein synthesis until 1982, when his adventitious discovery of the c...

    Authors: Tim Hunt

    Citation: BMC Biology 2015 13:64

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  3. Content type: Research article

    Insulators play a central role in gene regulation, chromosomal architecture and genome function in higher eukaryotes. To learn more about how insulators carry out their diverse functions, we have begun an anal...

    Authors: Artem Bonchuk, Oksana Maksimenko, Olga Kyrchanova, Tatyana Ivlieva, Vladic Mogila, Girish Deshpande, Daniel Wolle, Paul Schedl and Pavel Georgiev

    Citation: BMC Biology 2015 13:63

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  4. Content type: Research article

    Peptide transporters are membrane proteins that mediate the cellular uptake of di- and tripeptides, and of peptidomimetic drugs such as β-lactam antibiotics, antiviral drugs and antineoplastic agents. In spite...

    Authors: Rajendra Boggavarapu, Jean-Marc Jeckelmann, Daniel Harder, Zöhre Ucurum and Dimitrios Fotiadis

    Citation: BMC Biology 2015 13:58

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  5. Content type: Comment

    Some steroid drugs are designed for clinical use to combat muscle-wasting diseases, but are also used by athletes to improve their performance by increasing muscle strength or endurance. This study investigate...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:61

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  6. Content type: Comment

    Probiotic treatments are thought to increase the levels of commensal bacterial species that populate the human gut, causing no harm to their host and playing an important role in maintaining gut health. This s...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:60

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  7. Content type: Comment

    Shear stress in arteries, which is a measure of the force exerted by blood flow on the arterial wall, is associated with the location of lipid plaques that cause heart disease. In this study, a mathematical mo...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:62

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  8. Content type: Research article

    The functional consequences of whole genome duplications in vertebrate evolution are not fully understood. It remains unclear, for instance, why paralogues were retained in some gene families but extensively l...

    Authors: Ferdinand Marlétaz, Ignacio Maeso, Laura Faas, Harry V. Isaacs and Peter W. H. Holland

    Citation: BMC Biology 2015 13:56

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  9. Content type: Research article

    The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and...

    Authors: Ho-Su Sin, Andrey V. Kartashov, Kazuteru Hasegawa, Artem Barski and Satoshi H. Namekawa

    Citation: BMC Biology 2015 13:53

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  10. Content type: Methodology article

    Qualitative and quantitative measurements of motor performance are essential for characterizing perturbations of motor systems. Although several methods exist for analyzing specific motor tasks, few behavioral...

    Authors: César S. Mendes, Imre Bartos, Zsuzsanna Márka, Turgay Akay, Szabolcs Márka and Richard S. Mann

    Citation: BMC Biology 2015 13:50

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  11. Content type: Research article

    Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear which strategies they follow to fulfill that performance objective. Slow cycling of stem cells pr...

    Authors: Michael Chiang, Amanda Cinquin, Adrian Paz, Edward Meeds, Christopher A. Price, Max Welling and Olivier Cinquin

    Citation: BMC Biology 2015 13:51

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  12. Content type: Research article

    Malaria invasion of red blood cells involves multiple parasite-specific targets that are easily accessible to inhibitory compounds, making it an attractive target for antimalarial development. However, no curr...

    Authors: Danny W Wilson, Christopher D Goodman, Brad E Sleebs, Greta E Weiss, Nienke WM de Jong, Fiona Angrisano, Christine Langer, Jake Baum, Brendan S Crabb, Paul R Gilson, Geoffrey I McFadden and James G Beeson

    Citation: BMC Biology 2015 13:52

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  13. Content type: Research article

    Development and evaluation of new insect pest management tools is critical for overcoming over-reliance upon, and growing resistance to, synthetic, biological and plant-expressed insecticides. For transgenic c...

    Authors: Tim Harvey-Samuel, Neil I. Morrison, Adam S. Walker, Thea Marubbi, Ju Yao, Hilda L. Collins, Kevin Gorman, T. G. Emyr Davies, Nina Alphey, Simon Warner, Anthony M. Shelton and Luke Alphey

    Citation: BMC Biology 2015 13:49

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  14. Content type: Methodology article

    Genetic ablation of target cells is a powerful tool to study the origins and functions of cells, tissue regeneration, or pathophysiology in a human disease model in vivo. Several methods for selective cell ablati...

    Authors: Fumiaki Obata, Shiho Tanaka, Soshiro Kashio, Hidenobu Tsujimura, Ryoichi Sato and Masayuki Miura

    Citation: BMC Biology 2015 13:48

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  15. Content type: Forum

    Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological...

    Authors: Ewa K. Paluch, Celeste M. Nelson, Nicolas Biais, Ben Fabry, Jens Moeller, Beth L. Pruitt, Carina Wollnik, Galina Kudryasheva, Florian Rehfeldt and Walter Federle

    Citation: BMC Biology 2015 13:47

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  16. Content type: Question and answer

    Plants are able to sense UV-B through the UV-B photoreceptor UVR8. UV-B photon absorption by a UVR8 homodimer leads to UVR8 monomerization and interaction with the downstream signaling factor COP1. This then i...

    Authors: Roman Ulm and Gareth I Jenkins

    Citation: BMC Biology 2015 13:45

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  17. Content type: Research article

    In many insect species, fitness trade-offs exist between maximizing body size and developmental speed. Understanding how various species evolve different life history strategies requires knowledge of the physi...

    Authors: Nicole E. Hatem, Zhou Wang, Keelin B. Nave, Takashi Koyama and Yuichiro Suzuki

    Citation: BMC Biology 2015 13:44

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  18. Content type: Research article

    Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination...

    Authors: Jennifer A. Evans, Ting-Chung Suen, Ben L. Callif, Andrew S. Mitchell, Oscar Castanon-Cervantes, Kimberly M. Baker, Ian Kloehn, Kenkichi Baba, Brett J. W. Teubner, J. Christopher Ehlen, Ketema N. Paul, Timothy J. Bartness, Gianluca Tosini, Tanya Leise and Alec J. Davidson

    Citation: BMC Biology 2015 13:43

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